[Antistroke activity of Actoinvit (substance S-1) in experimental hemorrhagic stroke].

A model of hemorrhagic stroke (HS) (intracerebral posttraumatic hematoma) has been used to show that oral Actoinvit (substance S-1) in a daily dose of 500 mg/kg for 7 days causes a steady-state antistroke effect. At the same time the major neurological parameters became lower and the total indices of orientative-trying behavior improved 24 hours just after administration of the drug. Muscle tone, coordination of movements, and memory impairment recovered on days 7-14 after the simulation of HS. The course use of the agent prevented death from HS in 80% of the animals.

[Antithrombotic prophylaxis after surgical interventions on the major veins]. / Antitromboticheskaia profilaktika posle operativnykh vmeshatel'stv na magistral'nykh venakh.

Eight-year experience in conducting antithrombotic prophylaxis, by methods elaborated by the authors, in 93 patients operated on for acute thrombosis in the system of venae cavae superior and inferior is generalized. On the basis of the results, the authors advanced the main principle of antithrombotic prophylaxis, the necessity for simultaneous correction of disorders of blood coagulation, fibrinolysis, and aggregation of formed elements of the blood. They showed that the efficacy of postoperative antithrombotic prophylaxis depends on the presence and character of hemodynamic disorders in the involved extremity. It is established that general fractional heparinization is not suitable for antithrombotic prophylaxis due to low efficacy and high rate of hemorrhagic complications. Continuous regional infusion of rheopolyglucin-heparin mixture with nicotinic acid and Trental ensures in most cases correction of the thrombotic condition of hemostasis and effective prevention of rethrombosis of the major veins with minimum hazard of hemorrhagic complications.

[Physiopathological shifts in the blood coagulation system in embolism of major arteries of the limbs]. / Patofiziologicheskie sdvigi v svertyvaiushchei sisteme krovi pri embolii magistral'nykh arterii konechnostei

An examination of 51 patients with embolism of the major arteries of the extremities demonstrated that embolism accompanied by an ascending or descending thrombosis was characterized by a more significant increase of blood coagulation, fibrinase and antiplasmin level, and an enhancement of erythrocytes aggregation, than embolism without protracted thrombosis. A correlation was observed between the nature of the pathologic process (presence of protracted thrombosis, increased erythrocytes aggregation) and the degree of ischaemia in the diseased extremity. At the same time, no correlation was found between the pathologic process and the duration of the disease history.

[Changes in the microcirculation of the pericardium of the dog during adaptation to static muscular loads]. / Izmeneniia mikrotsirkuliatsii perikarda u sobak pri adaptatsii k staticheskim myshechnym nagruzkam.

The data obtained revealed an increase of physiological working ability, economizing of a number of functions on the systemic level as well as morphological parameters of the vascular microregion in the course of training--adaptation to muscular loads in dogs. Apart from that, an increasing permeability for water and protein was maintained due to a beneficial readjustment of the microregion--module communications as well as to augmentation of all the parameters of the metabolic link. Desadaptation led to decreasing physiological working ability and inadequate increase in the circulation and respiration on the level of systemic parameters. On the other hand, the transcapillary exchange of water and protein was significantly decreased with a respective morphological reduction of the pericardium capillaries' metabolic surface.

[Chemiluminescence of blood plasma in the presence of hydrogen peroxide]. / Khemiliuminestsentsiia plazmy krovi v prisutstvii perekisi vodoroda.

Chemoluminescence arised after incubation of diluted blood plasma with hydrogen peroxide. A typical pattern of the luminescence development, similar to that obtained on addition of H2O2 to other biological objects, was observed: quick increase and gradual decrease to a steady-state chemoluminescence level. The increase in chemoluminescence, which was noted in some experiments, might be due to elevation in content of both initiators of peroxidation and activators of the chemoluminescence in blood plasma. Kinetics of the chemoluminescence did not correlate with concentration of oxygen in media.

[The correction of motor-tonic disorders of the gastrointestinal tract and of duodenogastric reflux with laser radiation]. / Korrektsiia motorno-tonicheskikh narushenii zheludochno-kishechnogo trakta i duodenogastral'nogo refliuksa lazernym izlucheniem.

Forty-five patients with duodenogastric reflux and defective gastroduodenal motor tonicity (gastroduodenal hypotonia, duodenal hypertension, gastric hypotonia in combination with duodenal hypertension) were exposed to He--Ne laser radiation. The impact was focused on the biologically active points G14, TR5, VC15, E21. The treatment resulted in normalization of the gastrointestinal pressure gradient, in discontinuance or reduction of duodenogastric reflux.

[Characteristics of external respiration function and pulmonary circulation in patients with ischemic heart disease complicated by disorders of intraventricular conduction]. / Osobennosti funktsii vnechnego dykhaniia i legochnogo krovotoka u bol'nykh ishemicheskoi bolezn'iu serdtsa, oslozhnennoi narusheniiami vnutrizheludochkovoi provodimosti.

The authors provide evidence on the condition of external respiration and hemodynamic shifts in the lesser and greater circulation in coronary patients with bundle-branch block; establish early objective quantitative criteria of the diagnosis of hemodynamic impairment arising in formation of the above blocks basing on ECG, phonocardiography, echocardiography findings; compare hemodynamic effects of single-dose nitrosorbide and corinfar in the above patients. Nitrosorbide and corinfar correct hemodynamics and external respiration, the former being more effective in normalizing the greater, while corinfar the lesser circulation.

[Duodenogastric reflux in patients with alimentary obesity]. / Duodenogastral'nyi refliuks u bol'nykh s alimentarnym ozhireniem.

The authors analyze findings from a comprehensive clinical and instrumental evaluation of 59 patients presenting with duodenogastric reflux. The above findings suggest that underlying the duodenogastric reflux in those patients having surplus body mass might be hypotonia of the stomach, particularly its pyloric portion. In patients with body mass that do not deviate from physiologic norms regurgitation of bile into the stomach results from the presence of duodenal dyskinesia by hypertonic type. The results obtained suggest that patients with gastroduodenal reflux need treatment options for them to be carefully thought out. The above reflux appeared to be particularly pronounced in those patients presenting with alimentary obesity as per analysis of the gastric content. Patients with grade II obesity show more noticeable tonic disorders of the pyloric portion of the stomach.

[Comparative evaluation of the methods of treatment of acute thrombosis of the main veins]. / Sravnitel'naia otsenka metodov 8ntitromboticheskoi terapii ostrogo tromboza maoistral'nykh ven.

The experience with antithrombotic conservative treatment of 102 cases of acute thrombosis in the inferior vena cava system and in the deep veins of the lower extremities is generalized here. The suggested method permits to do away with thrombotic condition of hemostasis at a minimal risk of the occurrence of hemorrhagic complications.

[Improvement of hearing acuity using ergomyogenic blood autoserum]. / Povyshenie ostroty slukha pri ispolzovanii érgomiogennoi autosyvorotki krovi.

Biological activity of ergomyogenic autoserum (EAS) is attributed to the presence of natural hormonal-neuropeptide complex. Its administration to 25 healthy volunteers and 20 patients with neurosensory hypoacusis stage I-II resulted in improvement of hearing acuity in all the subjects with normal hearing and in 75% of the patients. The autoserum usage instructions are provided.