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Hum Genome Var
; 11(1): 27, 2024 Jul 26.
Article
in English
| MEDLINE
| ID: mdl-39060265
ABSTRACT
Biallelic IGFALS variants lead to acidâlabile subunit (ALS) deficiency characterized by growth hormone resistance with or without delayed puberty. Here, we report a prepubertal boy with a homozygous 2-amino acid deletion within the fourth N-glycosylation motif (c.1103_1108del, p.N368_S370delinsT) associated with parental consanguinity. He showed short stature consistent with ALS deficiency. This case expands the mutation spectrum of IGFALS to include the elimination of only one N-glycosylation motif of ALS.