Dual-stage hybrid network for single-shot fringe projection profilometry based on a phase-height model.

Single-shot fringe projection profilometry (FPP) is widely used in the field of dynamic optical 3D reconstruction because of its high accuracy and efficiency. However, the traditional single-shot FPP methods are not satisfactory in reconstructing complex scenes with noise and discontinuous objects. Therefore, this paper proposes a Deformable Convolution-Based HINet with Attention Connection (DCAHINet), which is a dual-stage hybrid network with a deformation extraction stage and depth mapping stage. Specifically, the deformable convolution module and attention gate are introduced into DCAHINet respectively to enhance the ability of feature extraction and fusion. In addition, to solve the long-standing problem of the insufficient generalization ability of deep learning-based single-shot FPP methods on different hardware devices, DCAHINet outputs phase difference, which can be converted into 3D shapes by simple multiplication operations, rather than directly outputting 3D shapes. To the best of the author's knowledge, DCAHINet is the first network that can be applied to different hardware devices. Experiments on virtual and real datasets show that the proposed method is superior to other deep learning or traditional methods and can be used in practical application scenarios.

TXNIP inhibition in the treatment of type 2 diabetes mellitus: design, synthesis, and biological evaluation of quinazoline derivatives.

Thioredoxin interacting protein (TXNIP) is a potential drug target for type 2 diabetes mellitus (T2DM) treatment. A series of quinazoline derivatives were designed, synthesised, and evaluated to inhibit TXNIP expression and protect from palmitate (PA)-induced ß cell injury. In vitro cell viability assay showed that compounds D-2 and C-1 could effectively protect ß cell from PA-induced apoptosis, and subsequent results showed that these two compounds decreased TXNIP expression by accelerating its protein degradation. Mechanistically, compounds D-2 and C-1 reduced intracellular reactive oxygen species (ROS) production and modulated TXNIP-NLRP3 inflammasome signalling, and thus alleviating oxidative stress injury and inflammatory response under PA insult. Besides, these two compounds were predicted to possess better drug-likeness properties using SwissADME. The present study showed that compounds D-2 and C-1, especially compound D-2, were potent pancreatic ß cell protective agents to inhibit TXNIP expression and might serve as promising lead candidates for the treatment of T2DM.

[Study on enhancing effect of ethanol in lower power ICP].

The effects of ethanol on physical propesties (density, viscosity, surface tension) of sample solution, plasma temperature and electron number density in the ICP were investigated. Detection limits of varying elements in ethanol-water system were determined. The experimental results showed that the gas temperature, excitation temperature and electron number density were lower than those in water solution, the electron temperature and ionization temperature were slightly reduced, while the velocity of aerosol to the plasma increased. The lower detection limits of rare earth elements were observed. The detection limits of other elements were the same as those with water solution. The mechanism of the enhancing effect was discussed.