[Prospects of antimicrobial drugs development on the basis of new synthetic substances].

The literature data concerning different chemical substances effects on microorganisms is considered in this paper. Synthetic substances screening is one of the promising ways of searching for new highly effective antimicrobial drugs. Previously those synthetic substances were not used in the clinical practice separately or in combinations as pharmacological products.

[Antimicrobial effect of 4-(adamantyl-1)-1-(1-aminobutyl)benzol].

Antimicrobial activity in vitro of adamantine derivative in respect of aerobic and anaerobic microorganisms has been studied. In these conditions Gram-positive bacteria and some representatives of Gram-negative microorganisms (Shigella flexneri, S. newvcastle, Enterobacter aerogenes etc.) had maximal sensitivity (MIC 0.6-5.0 and 0.1-5.0 mg/ml, respectively). Pseudomonas aeruginosa were resistant to this substance (MIC >1 mg/ml).