Subject(s)
Stevens-Johnson Syndrome/therapy , Adrenal Cortex Hormones/therapeutic use , Adult , Aftercare , Analgesia/methods , Biological Dressings , Critical Pathways , Cyclosporine/therapeutic use , Eye Diseases/therapy , Female , Female Urogenital Diseases/therapy , Fluid Therapy/methods , Forecasting , Humans , Immunoglobulins, Intravenous/therapeutic use , Lymphocyte Activation , Male , Male Urogenital Diseases/therapy , Mouth Diseases/therapy , Nutritional Support/methods , Prognosis , Respiratory Tract Diseases/therapy , Skin Care/methods , Skin Irritancy Tests/methods , Stevens-Johnson Syndrome/etiology , Stevens-Johnson Syndrome/pathologyABSTRACT
The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for the diagnosis and management of the full spectrum of Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and SJS-TEN overlap in adults during the acute phase of the disease. The document aims to.
Subject(s)
Disease Management , Practice Guidelines as Topic , Stevens-Johnson Syndrome , Adult , Diagnosis, Differential , Evidence-Based Practice , Humans , Patient Acuity , Skin/pathology , Stevens-Johnson Syndrome/diagnosis , Stevens-Johnson Syndrome/physiopathology , Stevens-Johnson Syndrome/therapy , United KingdomABSTRACT
All types of leukaemia can disseminate to the skin, producing cutaneous deposits known as leukaemia cutis (LC). We undertook a retrospective study to review the clinical presentations, treatment and outcome of eight patients with LC managed in our department over a period of 12 years. The clinical phenotype varied, with erythematous papules and nodules occurring with greatest frequency. Infiltrated haemorrhagic plaques and perifollicular acneiform papules were also seen. Although patients were treated aggressively for their underlying leukaemia, and received therapy directed towards LC, they tended to be refractory to treatment and the diagnosis was generally associated with a poor prognosis. The exception was a patient with chronic lymphocytic leukaemia, who survived 3 years after developing LC.
Subject(s)
Leukemia, Lymphocytic, Chronic, B-Cell/pathology , Leukemia, Myeloid/pathology , Leukemic Infiltration/therapy , Skin/pathology , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Retrospective Studies , Treatment OutcomeABSTRACT
Purpura fulminans is a rare syndrome of haemorrhagic necrosis of the skin and intravascular thrombosis associated with disseminated intravascular coagulopathy. It has not previously been reported as a presenting feature of Churg Strauss syndrome.
Subject(s)
Churg-Strauss Syndrome/diagnosis , IgA Vasculitis/diagnosis , Adult , Churg-Strauss Syndrome/pathology , Female , Humans , IgA Vasculitis/pathologyABSTRACT
The incidence of syphilis in the UK is rising, particularly in HIV-positive men. We describe a Caucasian, HIV-negative woman who presented with secondary syphilis taking the form known as lues maligna. She also demonstrated the prozone phenomenon whereby the rapid plasmin reagin test was negative, but the Venereal Disease Research Laboratory and Treponema pallidum haemagglutination tests were positive.