Off-line ion source terminal for ISAC at TRIUMF.

The off-line ion source (OLIS) terminal consists of a microwave cusp ion source, either a surface ion source or a hybrid surface-arc discharge ion source and an electrostatic switch that allows selecting any one of the sources without mechanical intervention. These sources provide variety of beams to ISAC experiments, for commissioning the accelerators, for setting up the radioactive experiments, and for tuning the beam lines. The microwave ion source has been operational since 1995 and provides singly and doubly charged beams from various stable isotopes for many ISAC experiments at high and low energy areas. Originally its prime goal was to provide beams from gaseous elements, but later two ovens and a sputtering system were added in order to provide beams from liquids and from solids. The surface ion source installed in 2002 can provide low energy spread beams from alkali and semialkali elements. It also has three separate ovens and an ionizer. Therefore, it can provide three different temperature regions simultaneously to provide different beams to ISAC. It is mainly used for laser spectroscopy experiments and other experiments, which require a finite beam quality. A hybrid surface-arc discharge ion source was also developed and installed in order to meet specific demands from experiments. This source terminal is now automated for start up and for mass selection. It is capable of providing stable beams for months without maintenance and it is also capable of providing negative ion beams if required. To date, over 40 different isotopes including many rear isotopes were delivered to various experiments from the OLIS source terminal. Performances of the ion sources and some of the results are discussed.

Pulmonary arteriovenous fistula. Preoperative evaluation with a Swan-Ganz catheter.

A balloon-tipped catheter was used in the preoperative assessment of a patient with a solitary pulmonary arteriovenous fistula and coexistent chronic obstructive pulmonary disease and ischemic heart disease. Studies before and two months following surgical excision of the fistula showed that the increase in arterial oxygenation (49 mm Hg vs 77 mm Hg) and the reduction in the fraction of the shunted cardiac output (37% vs 6%) closely approximated the predicted preoperative estimates.

A multicharge ion source (Supernanogan) for the OLIS facility at ISAC/TRIUMF.

The Off-Line Ion Source (OLIS) [K. Jayamanna, D. Yuan, T. Kuo, M. MacDonald, P. Schmor, and G. Dutto, Rev. Sci. Instrum. 67, 1061 (1996); K. Jayamanna, Rev. Sci. Instrum. 79, 02711 (2008)] facility consists of a high voltage terminal containing a microwave cusp ion source, either a surface ion source or a hybrid surface-arc discharge ion source [K. Jayamanna and C. Vockenhuber, Rev. Sci. Instrum. 79, 02C712 (2008)], and an electrostatic switch that allows the selection of any one of the sources without mechanical intervention. These sources provide a variety of +1 beams up to mass 30 for Isotope Separator and ACcelerator (ISAC) [R. E. Laxdal, Nucl. Instrum. Methods Phys. Res. B 204, 400 (2003)] experiments, commissioning the accelerators, setting up the radioactive experiments, and for tuning the beam lines. The radio frequency quadrupole (RFQ) [M. Marchetto, Z. T. Ang, K. Jayamanna, R. E. Laxdal, A. Mitra, and V. Zvyagintsev, Eur. Phys. J. Spec. Top. 150, 241 (2005)] injector accelerator is a constant velocity machine designed to accept only 2 keV/u and the source extraction energy is limited to 60 kV. Further stripping is then needed downstream of the RFQ to inject the beam into the drift tube linac [M. Marchetto, Z. T. Ang, K. Jayamanna, R. E. Laxdal, A. Mitra, and V. Zvyagintsev, Eur. Phys. J. Spec. Top. 150, 241 (2005)] accelerator that requires A/q up to 6. Base on this constraints a multicharge ion source capable to deliver beams above mass 30 with A/q up to 6 was needed in order to reach full capability of the ISAC facility. A Supernanogan [C. Bieth et al., Nucleonika 48, S93 (2003)] multicharge ion source was then purchased from Pantechnik and was installed in the OLIS terminal. Commissioning and performance of the Supernanogan with some results such as emittance dependence of the charge states as well as charge state efficiencies are presented.

The utility of transbronchial needle aspiration in the staging of bronchogenic carcinoma.

We conducted a prospective multi-institutional clinical study involving community hospitals and academic medical centers to more carefully define the value of computerized tomography (CT) of the chest with transbronchial needle aspiration (TBNA) in the staging of bronchogenic carcinoma (CA), and to assess the predictors of a positive aspirate. Of 360 individuals determined to have bronchogenic carcinoma, 50 of 81 (62%) with small cell carcinoma (SCC) and 135 of 279 (48%) with non-small cell carcinoma (NSCC) had positive aspirates (p = 0.034). TBNA precluded additional thoracic surgery in a total of 104 of 360 (29%) patients and was exclusively diagnostic of carcinoma in 65 of 360 (18%) cases. Right-sided tumors were more likely to have a positive mediastinal TBNA (p = 0.002 to 0. 01) as were histologic (67 of 118 [57%]) rather than cytology aspirates (228 of 532 [41%]) (p < 0.001). Sensitivity was > 57% in lymph nodes (LN) >/= 10 mm, and among LN of equivalent size, right paratracheal and subcarinal sites were most likely to establish malignancy. Preoperative CT is a valuable adjunct in the staging of CA by TBNA. Increasing LN size, right-sided tumors, right paratracheal and subcarinal locations, use of a histology needle, and the presence of SCC are the best predictors of a positive aspirate.