Search details
1.
Two-drug trick to target the brain blocks toxicity in the body.
Nature
; 609(7928): 681-683, 2022 09.
Article
in English
| MEDLINE | ID: mdl-36104488
2.
Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα.
J Am Chem Soc
; 144(14): 6326-6342, 2022 04 13.
Article
in English
| MEDLINE | ID: mdl-35353516
3.
A class of highly selective inhibitors bind to an active state of PI3Kγ.
Nat Chem Biol
; 15(4): 348-357, 2019 04.
Article
in English
| MEDLINE | ID: mdl-30718815
4.
Targeting Phosphoinositide 3-Kinase - Five Decades of Chemical Space Exploration.
Chimia (Aarau)
; 75(12): 1037-1044, 2021 Dec 22.
Article
in English
| MEDLINE | ID: mdl-34920774
5.
Lipid signalling in disease.
Nat Rev Mol Cell Biol
; 9(2): 162-76, 2008 Feb.
Article
in English
| MEDLINE | ID: mdl-18216772
6.
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.
Mol Cell
; 42(1): 84-95, 2011 Apr 08.
Article
in English
| MEDLINE | ID: mdl-21474070
7.
PKCß phosphorylates PI3Kγ to activate it and release it from GPCR control.
PLoS Biol
; 11(6): e1001587, 2013.
Article
in English
| MEDLINE | ID: mdl-23824069
8.
C-C motif chemokine CCL3 and canonical neutrophil attractants promote neutrophil extravasation through common and distinct mechanisms.
Blood
; 120(4): 880-90, 2012 Jul 26.
Article
in English
| MEDLINE | ID: mdl-22674804
9.
New molecular and therapeutic insights into canine diffuse large B-cell lymphoma elucidates the role of the dog as a model for human disease.
Haematologica
; 104(6): e256-e259, 2019 06.
Article
in English
| MEDLINE | ID: mdl-30545928
10.
PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance.
Proc Natl Acad Sci U S A
; 108(42): E854-63, 2011 Oct 18.
Article
in English
| MEDLINE | ID: mdl-21949398
11.
Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy.
J Allergy Clin Immunol
; 132(4): 959-68, 2013 Oct.
Article
in English
| MEDLINE | ID: mdl-23683463
12.
Cell-permeant and photocleavable chemical inducer of dimerization.
Angew Chem Int Ed Engl
; 53(18): 4717-20, 2014 Apr 25.
Article
in English
| MEDLINE | ID: mdl-24677313
13.
A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress.
J Exp Med
; 204(3): 497-510, 2007 Mar 19.
Article
in English
| MEDLINE | ID: mdl-17325199
14.
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization.
EMBO J
; 28(14): 2018-27, 2009 Jul 22.
Article
in English
| MEDLINE | ID: mdl-19574958
15.
Genetic ablation of PI3Kγ results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels.
Eur J Immunol
; 42(12): 3394-404, 2012 Dec.
Article
in English
| MEDLINE | ID: mdl-22930133
16.
Investigation of morpholine isosters for the development of a potent, selective and metabolically stable mTOR kinase inhibitor.
Eur J Med Chem
; 248: 115038, 2023 Feb 15.
Article
in English
| MEDLINE | ID: mdl-36634458
17.
Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3Kγ-dependent fluid-phase pinocytosis of native LDL.
J Lipid Res
; 53(1): 34-42, 2012 Jan.
Article
in English
| MEDLINE | ID: mdl-22058424
18.
The chemical biology of phosphoinositide 3-kinases.
Chembiochem
; 13(14): 2022-35, 2012 Sep 24.
Article
in English
| MEDLINE | ID: mdl-22965647
19.
Phosphoinositide 3-kinase in disease: timing, location, and scaffolding.
Curr Opin Cell Biol
; 17(2): 141-9, 2005 Apr.
Article
in English
| MEDLINE | ID: mdl-15780590
20.
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.
Nat Med
; 11(9): 936-43, 2005 Sep.
Article
in English
| MEDLINE | ID: mdl-16127437