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1.
An activity-based fluorogenic probe for sensitive and selective monoamine oxidase-B detection.
Long, Shaobo; Chen, Lin; Xiang, Yumi; Song, Minggui; Zheng, Yuguo; Zhu, Qing.
Chem Commun (Camb) ; 48(57): 7164-6, 2012 Jul 21.
Article in English | MEDLINE | ID: mdl-22692558

ABSTRACT

We report the design and synthesis of a new class of fluorogenic probes based on monoamine oxidase-triggered oxidative C-O bond cleavage. The selectivity of probe P1 towards MAO-B was 22-fold higher than that towards MAO-A.


Subject(s)
Coumarins/chemistry , Enzyme Assays/methods , Fluorescent Dyes/chemistry , Monoamine Oxidase/metabolism , Binding Sites , Coumarins/metabolism , Fluorescent Dyes/metabolism , Humans , Models, Molecular , Monoamine Oxidase/analysis , Oxidation-Reduction , Protein Binding , Sensitivity and Specificity , Spectrometry, Fluorescence/methods
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