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Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
; 26(4): 453-6, 2014 Aug.
Article
in Zh
| MEDLINE
| ID: mdl-25434152
ABSTRACT
Rhoptry proteins are the major virulence factors of Toxoplasma gondii. They locate in different parts of the host cells, and can affect the membrane, cytoskeleton structure and active factors of the host cells, so as to block the cell intrinsic defense mechanisms of the host, and let T. gondii invade, parasitize and proliferate in the host successfully. The function and ac- tion mode of rhoptry proteins reflect the pathogenic mechanism of T. gondii, which holds great significance to looking for toxoplasmosis drug targets and developing molecule vaccines. This paper reviews the research progess of the interaction between rhoptry proteins of T. gondii and host cells.
Subject(s)
Protozoan Proteins/metabolism , Toxoplasma/metabolism , Animals , Cell Membrane/metabolism , Host-Parasite Interactions , Protein Transport , Signal Transduction , Toxoplasma/physiology
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