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1.
Opt Express ; 31(18): 29900-29911, 2023 Aug 28.
Article in English | MEDLINE | ID: mdl-37710779

ABSTRACT

Dielectric metasurface empowering efficient light polarization control at the nanoscale, has recently garnered tremendous research interests in the field of high-resolution image encryption and display, particularly at low-loss wavelengths in the visible band. Nevertheless, due to the single fixed polarization conversion function, the image (either positive or negative image) can always be decrypted in a host-uncontrollable manner as long as the user applies an analyzer to select the polarization component of the output light. Here, we resort to half-waveplate- and quarter-waveplate-like silicon nanopillars to form a metamolecule of a dielectric diatomic metasurface, which can yield versatile linearly polarized (LP) and circularly polarized (CP) light upon orthogonally linear-polarized incidences, providing new degrees of freedom for image display and encryption. We show both theoretically and numerically that versatile different paired LP and CP combinations could be achieved by simply adjusting the orientation angles of the two nanopillars. The bifunctional polarization conversion functions make possible that a meta-image can only be seen when incident light is linearly polarized at a specific polarization angle, whereas no image can be discerned for the orthogonal polarization incidence case, indicating the realization of incidence-polarization secured meta-image. This salient feature holds for all individual metamolecules, reaching a remarkable image resolution of 52,916 dots per inch. By fully exploiting all polarization conversions of four designed metamolecules, three-level incidence polarization-secured meta-image can also be expected.

2.
Opt Express ; 31(26): 44139-44147, 2023 Dec 18.
Article in English | MEDLINE | ID: mdl-38178492

ABSTRACT

Metasurface has garnered significant attention in the field of optical encryption as it allows the integration and occultation of multiple grayscale nanoprinting images on a single platform. However, in most cases, polarization serves as the only key for encryption/decryption, and the risk of being cracked is relatively high. In this study, we propose a three-fold information encryption strategy based on a dielectric metasurface, in which a colorful nanoprinting image and two grayscale images are integrated on such a single platform. Unlike previous works based on the orientation-angle degenerated light intensity, the proposed image encryptions are realized by customizing nanobricks with polarization-mediated similar/different transmission characteristics in either broadband or at discrete wavelengths. Different combinations of polarization and monochromatic wavelengths can form three keys with different levels of decryption complexity as compared to the previous counterpart based merely on polarization. Once illuminated by non-designed wavelengths or polarized light, messy images with false information will be witnessed. Most importantly, all images are safely secured by the designated incidence polarization and cannot be decrypted via an additional analyzer as commonly happens in conventional metasurface-based nanoprinting. The proposed metasurface provides an easy-to-design and easy-to-disguise scheme for multi-channel display and optical information encryption.

3.
Chem Soc Rev ; 51(9): 3341-3379, 2022 May 10.
Article in English | MEDLINE | ID: mdl-35293907

ABSTRACT

Perovskite materials have driven tremendous advances in constructing electronic devices owing to their low cost, facile synthesis, outstanding electric and optoelectronic properties, flexible dimensionality engineering, and so on. Particularly, emerging nonvolatile memory devices (eNVMs) based on perovskites give birth to numerous traditional paradigm terminators in the fields of storage and computation. Despite significant exploration efforts being devoted to perovskite-based high-density storage and neuromorphic electronic devices, research studies on materials' dimensionality that has dominant effects on perovskite electronics' performances are paid little attention; therefore, a review from the point of view of structural morphologies of perovskites is essential for constructing perovskite-based devices. Here, recent advances of perovskite-based eNVMs (memristors and field-effect-transistors) are reviewed in terms of the dimensionality of perovskite materials and their potentialities in storage or neuromorphic computing. The corresponding material preparation methods, device structures, working mechanisms, and unique features are showcased and evaluated in detail. Furthermore, a broad spectrum of advanced technologies (e.g., hardware-based neural networks, in-sensor computing, logic operation, physical unclonable functions, and true random number generator), which are successfully achieved for perovskite-based electronics, are investigated. It is obvious that this review will provide benchmarks for designing high-quality perovskite-based electronics for application in storage, neuromorphic computing, artificial intelligence, information security, etc.

4.
Phys Chem Chem Phys ; 24(41): 25270-25278, 2022 Oct 27.
Article in English | MEDLINE | ID: mdl-36222416

ABSTRACT

We show that ultra-cold polar diatomic or linear molecules, oriented in an external electric field and mutually coupled by dipole-dipole interactions, can be used to realize the exact Heisenberg XYZ, XXZ and XY models without invoking any approximation. The two lowest lying excited pendular states coupled by microwave or radio-frequency fields are used to encode the pseudo-spin. We map out the general features of the models by evaluating the models constants as functions of the molecular dipole moment, rotational constant, strength and direction of the external field as well as the distance between molecules. We calculate the phase diagram for a linear chain of polar molecules based on the Heisenberg models and discuss their drawbacks, advantages, and potential applications.

5.
Small ; 17(41): e2100804, 2021 10.
Article in English | MEDLINE | ID: mdl-34240560

ABSTRACT

Template methods are regarded as an important method for micro-nano processing in the active layer of flexible tactile sensors. These template methods use physical/chemical processes to introduce micro-nano structures on the active layer, which improves many properties including sensitivity, response/recovery time, and detection limit. However, since the processing process and applicable conditions of the template method have not yet formed a perfect system, the development and commercialization of flexible tactile sensors based on the template method are still at a relatively slow stage. Despite the above obstacles, advances in microelectronics, materials science, nanoscience, and other disciplines have laid the foundation for various template methods, enabling the continuous development of flexible tactile sensors. Therefore, a comprehensive and systematic review of flexible tactile sensors based on the template method is needed to further promote progress in this field. Here, the unique advantages and shortcomings of various template methods are summarized in detail and discuss the research progress and challenges in this field. It is believed that this review will have a significant impact on many fields of flexible electronics, which is beneficial to promote the cross-integration of multiple fields and accelerate the development of flexible electronic devices.


Subject(s)
Electronics , Touch
6.
Microb Pathog ; 150: 104707, 2021 Jan.
Article in English | MEDLINE | ID: mdl-33352216

ABSTRACT

OBJECTIVE: To investigate the communities of fecal microbiota and the role of Toll-like receptors in patients with ulcerative colitis in the coastal area of northern China. METHODS: Stool samples from 31 patients with ulcerative colitis and 12 healthy individuals were collected. The total bacterial genomic DNA was extracted, and the V3+V4 hypervariable region in the bacterial 16S rRNA gene sequence was amplified by polymerase chain reaction (PCR). High-throughput sequencing analysis was performed on the Illumina Hiseq platform. The expression of TLR2, TLR4, Tollip, PPAR-γ, IL-6, and TNF-α in the colonic mucosa was measured by Western blots. RESULTS: The diversity of the fecal microbiota in patients with ulcerative colitis was significantly less than that in healthy control individuals (p < 0.05). The proportion of Bacteroidetes was significantly reduced (p < 0.01), whereas Proteobacteria was prevalent (p < 0.01) in patients with ulcerative colitis. At the genus level, the relative abundance of Streptococcus and Anaerostipes was significantly increased (p < 0.05), whereas the proportion of Bacteroides, Lachnospira, Ruminococcus, Phascolarctobacterium, and Coprococcus was significantly decreased in patients with ulcerative colitis (p < 0.05). The diversity indexes of fecal microbiota in patients with ulcerative colitis were negatively correlated with disease severity (p < 0.05). The relative abundance of Enterobacteriaceae was positively correlated with disease severity, and the relative abundance of Phascolarctobacterium, Anaerostipes, Fusobacterium, Parabacteroides, Oscillospira, and Ochrobactrum were negatively correlated with disease severity. The expression levels of TLR2 and TLR4 in the intestinal mucosa were positively correlated with the relative abundance of Streptococcus and Enterobacteriaceae, respectively (r = 0.481, p = 0.007; r = 0.455, p = 0.017). CONCLUSION: There were significant changes in the diversity and composition of the fecal microbiota in patients with ulcerative colitis compared to healthy individuals. The dysbiosis of gut microbiota and correlation with TLRs might play important roles in the pathogenesis and progression of ulcerative colitis.


Subject(s)
Colitis, Ulcerative , Gastrointestinal Microbiome , China , Dysbiosis , Feces , Humans , RNA, Ribosomal, 16S/genetics
7.
Small ; 16(4): e1904774, 2020 01.
Article in English | MEDLINE | ID: mdl-31885133

ABSTRACT

The tactile sensor lies at the heart of electronic skin and is of great importance in the development of flexible electronic devices. To date, it still remains a critical challenge to develop a large-scale capacitive tactile sensor with high sensitivity and controllable morphology in an economical way. Inspired by the interlocked microridges between the epidermis and dermis, herein, a highly sensitive capacitive tactile sensor by creating interlocked asymmetric-nanocones in poly(vinylidenefluoride-co-trifluoroethylene) film is proposed. Particularly, a facile method based on cone-shaped nanoporous anodized aluminum oxide templates is proposed to cost-effectively fabricate the highly ordered nanocones in a controllable manner and on a large scale. Finite-element analysis reveals that under vertical forces, the strain/stress can be highly strengthened and localized at the contact apexes, resulting in an amplified variation of film permittivity and thickness. Benefiting from this, the developed tactile sensor presents several conspicuous features, including the maximum sensitivity (6.583 kPa-1 ) in the low pressure region (0-100 Pa), ultralow detection limit (≈3 Pa), rapid response/recovery time (48/36 ms), excellent stability and reproducibility (10 000 cycles). These salient merits enable the sensor to be successfully applied in a variety of applications including sign language gesture detection, spatial pressure mapping, Braille recognition, and physiological signal monitoring.


Subject(s)
Biosensing Techniques , Pressure , Touch , Biosensing Techniques/instrumentation , Biosensing Techniques/standards , Dermis/physiology , Electronics , Epidermis/physiology , Limit of Detection , Reproducibility of Results
8.
Sensors (Basel) ; 20(6)2020 Mar 11.
Article in English | MEDLINE | ID: mdl-32168963

ABSTRACT

The increase in the number of people suffering diabetes has been the driving force behind the development of glucose sensors to overcome the current testing shortcomings. In this work, a reusable, non-invasive and ultrafast radio frequency biosensor based on optimized integrated passive device fabrication process for quantitative detection of glucose level was developed. With the aid of the novel biosensor design with hammer-shaped capacitors for carrying out detection, both the resonance frequency and magnitude of reflection coefficient can be applied to map the different glucose levels. Meanwhile, the corresponding fabrication process was developed, providing an approach for achieving quantitative detection and a structure without metal-insulator-metal type capacitor that realizes low cost and high reliability. To enhance the sensitivity of biosensor, a 3-min dry etching treatment based on chlorine/argon-based plasma was implemented for realizing hydrophilicity of capacitor surface to ensure that the biosensor can be touched rapidly with glucose. Based on above implementation, a non-invasive biosensor having an ultrafast response time of superior to 0.85 s, ultralow LOD of 8.01 mg/dL and excellent reusability verified through five sets of measurements are realized. The proposed approaches are not limited the development of a stable and accurate platform for the detection of glucose levels but also presents a scheme toward the detection of glucose levels in human serum.


Subject(s)
Biosensing Techniques/instrumentation , Blood Glucose Self-Monitoring/instrumentation , Blood Glucose/analysis , Biosensing Techniques/methods , Blood Glucose Self-Monitoring/methods , Diabetes Mellitus , Equipment Design , Humans , Limit of Detection , Radio Waves
9.
Opt Express ; 27(24): 35027-35040, 2019 Nov 25.
Article in English | MEDLINE | ID: mdl-31878679

ABSTRACT

Silicon dielectric metasurfaces based on a square lattice of nanoparticles have been extensively utilized to create transmissive structural colors. Yet it is a huge challenge to obtain stable yellow color with high saturation due to the relatively large absorption of silicon in the short wavelength regime and the applied square lattice. In this study, we propose a new design strategy of independently altering the mutually perpendicular periods of a hydrogenated amorphous silicon nanodisk array-enabled metasurface to meticulously modulate the transmission spectra for the realization of high-saturation and stable cyan, magenta and yellow (CMY) color pixels. By introducing rectangular lattice, the yellow pixel can provide a narrowband transmission spectrum with a highly suppressed dip at 455 nm. The high suppression in transmission contributes to give rise to high-saturation yellow color. The attained narrowband spectrum that enables low spectral cross-talk is attributed to the overlap between magnetic dipole resonance excited by individual nanodisks and lattice resonance arising from the dipole coupling between the nanodisks. Compared with the square lattice, the proposed pixels exhibit fairly stable output color responses for a large period range. Meanwhile, the proposed CMY pixels are capable of both the relaxed angular tolerance and low dependence on the incident polarization states. It is anticipated that the proposed color pixels pave the way for extensive applications in compact color displays.

10.
Opt Express ; 24(15): 17115-24, 2016 Jul 25.
Article in English | MEDLINE | ID: mdl-27464162

ABSTRACT

A polarization-mediated color filter featuring a high angular tolerance is proposed incorporating a metal-dielectric-metal etalon based on a nanostructured cavity, where a one-dimensional subwavelength grating of a high refractive index is embedded in a base layer of a low refractive index. The aim of the nanostructured cavity is mimicking of the equivalent birefringent medium whereby different effective refractive indices are exhibited depending on the incident polarization. As the transmission peak of the etalon is effectively tuned through the tailoring of the refractive index of the cavity, the proposed filter is capable of providing a continuum of vivid output colors through a dynamic control of the polarization. The effective medium theory is chiefly applied for an investigation of the birefringent characteristics of the nanostructured cavity. A dielectric overlay that acts as an anti-reflection coating is specifically adopted for the etalon to enhance the transmission efficiency. The proposed polarization-tuned filter evidently provides a high transmission of ~71% and a high angular tolerance of ~35° in conjunction with a wide polarization-mediated color tuning.

11.
Opt Express ; 23(21): 27474-83, 2015 Oct 19.
Article in English | MEDLINE | ID: mdl-26480407

ABSTRACT

Reflection type subtractive tri-color filters, enabling metal-thickness tolerant high color saturation, were proposed and demonstrated capitalizing on a nanoporous metal-dielectric-metal (MDM) resonant structure, which comprises a cavity made of self-assembled nanoporous anodic aluminum oxide (AAO), sandwiched between an Al film of the same nanoporous configuration and a highly reflective aluminum (Al) substrate. For the proposed filter, the output color was easily determined by controlling the resonance wavelength via the thickness of the porous AAO cavity. In particular, the spectral response was deemed to exhibit a near-zero resonant dip, thereby achieving enhanced color saturation, which was stably maintained irrespective of the thickness of the porous Al film, due to its reduced effective refractive index. In order to manufacture the proposed color filters on a large scale, a porous Al film of hexagonal lattice configuration was integrated with an identically porous self-assembled AAO layer, which has been grown on an Al substrate. For the realized tri-color filters for cyan, magenta, and yellow (CMY), having a 15-nm Al film, near-zero reflection dips were observed to be centered at the wavelengths of 436, 500, and 600 nm, respectively. The resulting enhanced color saturation was stably maintained even though the variations were as large as 10 nm in the metal thickness.

12.
Appl Opt ; 54(18): 5866-71, 2015 Jun 20.
Article in English | MEDLINE | ID: mdl-26193041

ABSTRACT

Highly efficient tri-color filters having uniform thickness are proposed based on an etalon tapping into a nanostructured cavity, where a hexagonal lattice of nanopillars (NPs) with a high refractive index is embedded in a base material with a low index. The nanostructured cavity is presumed to behave as a homogeneous medium, which provides a wide range for the effective refractive index in accordance with both the volume fraction of the NPs and the index contrast between the NPs and the base. Hence, for the etalon-based filters, the resonance wavelength can be efficiently tuned by simply altering the effective index rather than the thickness of the cavity, so as to span the entire visible regime including red, green, and blue (RGB) colors. In particular, a hexagonal lattice of NPs was introduced to extend the available range of effective index due to its highly flexible volume fraction. The NP-base index contrast has been pertinently maximized to achieve effective indices leading to RGB colors, to the extent that the nanostructured cavity can be safely modeled as a homogeneous medium. The proposed RGB color filters were finally designed to have an identical thickness of 240 nm by setting the diameters of the NPs at 95, 70, and 40 nm, to achieve a periodicity of 100 nm, considering that TiO2 and Al2O3 can be practically selected as the material candidate for the NPs and the base, respectively. A high transmittance of ∼78% and a suitable 1 dB bandwidth of ∼51 nm were obtained for the tri-color filters, which were further confirmed to exhibit polarization-independent transfer characteristics.

13.
Sensors (Basel) ; 14(11): 20500-18, 2014 Oct 30.
Article in English | MEDLINE | ID: mdl-25360579

ABSTRACT

Maintaining effective coverage and extending the network lifetime as much as possible has become one of the most critical issues in the coverage of WSNs. In this paper, we propose a multi-objective coverage optimization algorithm for WSNs, namely MOCADMA, which models the coverage control of WSNs as the multi-objective optimization problem. MOCADMA uses a memetic algorithm with a dynamic local search strategy to optimize the coverage of WSNs and achieve the objectives such as high network coverage, effective node utilization and more residual energy. In MOCADMA, the alternative solutions are represented as the chromosomes in matrix form, and the optimal solutions are selected through numerous iterations of the evolution process, including selection, crossover, mutation, local enhancement, and fitness evaluation. The experiment and evaluation results show MOCADMA can have good capabilities in maintaining the sensing coverage, achieve higher network coverage while improving the energy efficiency and effectively prolonging the network lifetime, and have a significant improvement over some existing algorithms.

14.
J Hazard Mater ; 448: 130894, 2023 Apr 15.
Article in English | MEDLINE | ID: mdl-36739844

ABSTRACT

Non-thermal plasma (NTP) is emerging as an attractive method for decomposing volatile organic compounds (VOCs). In this paper, to study toluene degradation mechanism in air/H2O dielectric barrier discharge (DBD) plasma, optical emission spectrometry (OES) was employed to in-situ monitor active species in plasma, with the permanent degradation products being detected by on-line mass spectrometry under various operations. A detailed kinetic model of NTP with incorporation of non-constant electron filed and thermal effects has also been established. A toluene degradation efficiency > 82% could be achieved at P = 115 W, Cin, toluene = 1000 ppm. The relative spectrum intensity of excited OH, O, H and N2 (A3Σ+u) increased with increase of discharge power and was decreased at higher gas flowrates. Toluene degradation was mainly induced by oxidation of OH and O at afterglow stage, while part of toluene was decomposed by attack of electrons and reactive particles N2 (A3Σ+u) in discharge stage. A toluene degradation pathway has been proposed as: toluene→benzyl→benzaldehyde→benzene→phenoxy→cyclopentadiene→polycarbenes/alkynol→CO2/H2O. Benzoquinone, benzaldehyde, cyclopentadiene and cyclopentadienyl are supposed to be important intermediates for the ring-opening of toluene. Clarification of toluene degradation behaviors at discharge and afterglowing stage could provide new insights for plasma-catalytic process in future.

15.
Comput Intell Neurosci ; 2022: 6106853, 2022.
Article in English | MEDLINE | ID: mdl-35875752

ABSTRACT

UAV (unmanned aerial vehicle) captured images have small pedestrian targets and loss of key information after multiple down sampling, which are difficult to overcome by existing methods. We propose an improved YOLOv4 model for pedestrian detection and counting in UAV images, named YOLO-CC. We used the lightweight YOLOv4 for pedestrian detection, which replaces the backbone with CSPDarknet-34, and two feature layers are fused by FPN (Feature Pyramid Networks). We expanded the perception field using multiscale convolution based on the high-level feature map and generated the population density map by feature dimension reduction. By embedding the density map generation method into the network for end-to-end training, our model can effectively improve the accuracy of detection and counting and make feature extraction more focused on small targets. Our experiments demonstrate that YOLO-CC achieves 21.76 points AP50 higher than that of the original YOLOv4 on the VisDrone2021-counting data set while running faster than the original YOLOv4.


Subject(s)
Pedestrians , Humans , Remote Sensing Technology/methods
16.
Adv Mater ; 34(31): e2202622, 2022 Aug.
Article in English | MEDLINE | ID: mdl-35648867

ABSTRACT

Traditional electronic skin (e-skin), due to the lack of human-brain-like thinking and judging capability, is powerless to accelerate the pace to the intelligent era. Herein, artificial intelligence (AI)-motivated full-skin bionic (FSB) e-skin consisting of the structures of human vellus hair, epidermis-dermis-hypodermis, is proposed. Benefiting from the double interlocked layered microcone structure and supercapacitive iontronic effect, the FSB e-skin exhibits ultrahigh sensitivity of 8053.1 kPa-1 (<1 kPa), linear sensitivity of 3103.5 kPa-1 (1-34 kPa), and fast response/recovery time of <5.6 ms. In addition, it can realize the evolution from tactile perception to advanced intelligent tactile cognition after being equipped with a "brain". First, static/dynamic contactless tactile perception is achieved based on the triboelectric effect of the vellus hair bionics. Second, the supercapacitive iontronic effect based structural bionics of the epidermis-dermis-hypodermis and a five-layer multilayer perception (MLP) enable the general intelligent tactile cognition of gesture cognition and robot interaction. Most importantly, by making full use of the FSB e-skin with a six-layer MLP neural network, an advanced intelligent material cognition system is developed for real-time cognition of the object material species and locations via one contact, which surpasses the capability of humans.


Subject(s)
Touch Perception , Wearable Electronic Devices , Artificial Intelligence , Bionics , Cognition , Humans , Intelligence
17.
Adv Sci (Weinh) ; 9(28): e2105577, 2022 10.
Article in English | MEDLINE | ID: mdl-35945187

ABSTRACT

Possessing the merits of high efficiency, low consumption, and versatility, emerging photonic memristive and memristive-like devices exhibit an attractive future in constructing novel neuromorphic computing and miniaturized bionic electronic system. Recently, the potential of various emerging materials and structures for photonic memristive and memristive-like devices has attracted tremendous research efforts, generating various novel theories, mechanisms, and applications. Limited by the ambiguity of the mechanism and the reliability of the material, the development and commercialization of such devices are still rare and in their infancy. Therefore, a detailed and systematic review of photonic memristive and memristive-like devices is needed to further promote its development. In this review, the resistive switching mechanisms of photonic memristive and memristive-like devices are first elaborated. Then, a systematic investigation of the active materials, which induce a pivotal influence in the overall performance of photonic memristive and memristive-like devices, is highlighted and evaluated in various indicators. Finally, the recent advanced applications are summarized and discussed. In a word, it is believed that this review provides an extensive impact on many fields of photonic memristive and memristive-like devices, and lay a foundation for academic research and commercial applications.


Subject(s)
Electronics , Neural Networks, Computer , Photons , Reproducibility of Results
18.
Front Oncol ; 11: 696078, 2021.
Article in English | MEDLINE | ID: mdl-34900665

ABSTRACT

BACKGROUND: Circular RNAs (CircRNAs) feature prominently in the progression of various cancers. However, the biological functions of many circRNAs in hepatocellular carcinoma (HCC) are far from fully clarified. This work is performed to decipher the function of circ_0000098 (circSLC30A7) in modulating the progression of HCC and its molecular mechanism. METHODS: Microarray data (GSE97332) were available from the Gene Expression Omnibus (GEO) database, and circRNA differentially expressed in HCC tissues was screened out by GEO2R tool. Circ_0000098, microRNA-1204 (miR-1204), and aristaless-like homeobox-4 (ALX4) mRNA expressions were detected by quantitative real-time polymerase chain reaction (qRT-PCR). Cell counting kit-8 (CCK-8), scratch wound healing, and Transwell assays were adopted to determine proliferation, migration, and invasion of HCC cells. ALX4 protein, E-cadherin, N-cadherin, and Vimentin expressions were evaluated by Western blot. In addition, the targeting relationship between miR-1204 and circ_0000098 or ALX4 was studied with dual-luciferase reporter assay and RIP assay. RESULTS: Circ_0000098 expression level was markedly declined in HCC tissues and cells, and its underexpression was associated with larger tumor size of HCC patients. Knocking down circ_0000098 observably promoted the multiplication, migration, invasion, and epithelial-mesenchymal transition (EMT) of Huh7 and SMMC-7721 cells. Additionally, circ_0000098 was mainly distributed in the cytoplasm of HCC cells, and up-regulated ALX4 expression through competitively decoying miR-1204. CONCLUSION: Circ_0000098, as a competitive endogenous RNA (ceRNA) of miR-1204, upregulates ALX4 expression and suppresses the growth, migration, invasion, and EMT of HCC cells.

19.
Front Oncol ; 11: 626620, 2021.
Article in English | MEDLINE | ID: mdl-33937030

ABSTRACT

Background: Colorectal cancer (CRC), the most commonly diagnosed cancer in the world, has a high mortality rate. In recent decades, long non-coding RNAs (lncRNAs) have been proven to exert an important effect on CRC growth. However, the CTBP1-AS2 expression and function in CRC are largely unknown. Materials and Methods: The CTBP1-AS2 and miR-93-5p expression in CRC and para-cancerous tissues was detected by reverse transcription-PCR. The expression of CTBP1-AS2, miR-93-5p and the transforming growth factor-beta (TGF-ß)/small mothers against decapentaplegic 2/3 (SMAD2/3) pathway was selectively regulated to study the correlation between CTBP1-AS2 expression and prognosis of patients with CRC. CRC cell proliferation, apoptosis, and invasion were measured in vivo and in vitro. In addition, bioinformatics was applied to explore the targeting relationship between CTBP1-AS2 and miR-93-5p. The targeting binding sites between CTBP1-AS2 and miR-93-5p, as well as between miR-93-5p and TGF-ß, were verified by the dual-luciferase reporter assay and the RNA immunoprecipitation experiment. Results: Compared with normal para-cancerous tissues, CTBP1-AS2 was considerably overexpressed in CRC tissues and was closely associated with worse survival of patients with CRC. Functionally, gain and loss in experiments illustrated that CTBP1-AS2 accelerated CRC cell proliferation and invasion and inhibited cell apoptosis. Mechanistically, CTBP1-AS2 regulated the malignant phenotype of tumor cells through the TGF-ß/SMAD2/3 pathway. Moreover, miR-93-5p, as an endogenous competitive RNA of CTBP1-AS2, attenuated the oncogenic effects mediated by CTBP1-AS2. Conclusion: CTBP1-AS2 promotes the TGF-ß/SMAD2/3 pathway activation by inhibiting miR-93-5p, thereby accelerating CRC development.

20.
ACS Appl Mater Interfaces ; 13(12): 14497-14506, 2021 Mar 31.
Article in English | MEDLINE | ID: mdl-33745274

ABSTRACT

Optical metasurface has exhibited unprecedented capabilities in the regulation of light properties at a subwavelength scale. In particular, a multifunctional polarization metasurface making use of light polarization to integrate distinct functionalities on a single platform can be greatly helpful in the miniaturization of photonic systems and has become a hot research topic in recent years. Here, we propose and demonstrate an efficient all-dielectric diatomic metasurface, the unit cell of which is composed of a pair of a-Si:H-based nanodisks and nanopillars that play the roles as polarization-maintaining and polarization-converting meta-atoms, respectively. Through rigorous theoretical analyses and numerical simulations, we show that a properly designed diatomic metasurface can work as a nanoscale linear polarizer for generating linearly polarized light with a controllable polarization angle and superior performances including a maximum transmission efficiency of 96.2% and an extinction ratio of 32.8 dB at an operation wavelength of 690 nm. Three metasurface samples are fabricated and experimentally characterized to verify our claims and their potential applications. Furthermore, unlike previously reported dielectric diatomic metasurfaces which merely manipulate the polarization state, the proposed diatomic metasurface can be easily modified to empower 1-bit phase modulation without altering the polarization angle and sacrificing the transmission efficiency. This salient feature further leads to the demonstration of a metasurface beam splitter that can be equivalently seen as the integration of a nonpolarizing beam splitter and a linear polarizer, which has never been reported before. We envision that various metadevices equipping with distinct wavefront shaping functionalities can be realized by further optimizing the diatomic metasurface to achieve an entire 2π phase control.

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