A systematic examination of the neural correlates of subjective time perception with fMRI and tDCS.

The ability to keep track of time is one of the fundamental human behaviours that enhance survival in the wild. It is still an essential skill that enables an individual to function well in modern society. In the present study, we tested the attentional gate model, one of the most common conceptual frameworks in studies of subjective time perception. Its utility has been well established, but it has been criticised for its lack of neurophysiological support; few studies attempted to systematically identify its components and their neural correlates. Previous studies established that the dorsolateral prefrontal cortex (DLPFC) was associated with working memory tasks and a correlation between activity in the cerebellum and the timing of tasks. An fMRI study was conducted to confirm that these two cortical regions were activated during the execution of a new time discrimination task that considers individual variations in subjective time perception. Simulations were conducted to optimize the electrode placement in order to maximize the electric fields of tDCS perturbation to these two areas. According to the attentional gate model, hypotheses about tDCS perturbation to subjective time perception, attention and working memory were formulated and tested. Attention and working memory were measured by the attention network and N-back tasks. There are weak effects to the perceived subjective equivalent and the reaction time in the attention network task, but both are not statistically significant after correction for multiple comparisons. Exploration analyses show a link between attention and subjective time perception after tDCS perturbation. To conclude, the results do not support the attentional gate model, but show a linkage between attention and subjective time perception in terms of similar neural circuits and their relationships under certain circumstances.

An improved anatomical MRI technique with suppression of fixative fluid artifacts for the investigation of human postmortem brain phantoms.

PURPOSE: Phantoms are often used to assess MR system stability in multicenter studies. Postmortem brain phantoms best replicate human brain anatomy, allowing for a combined assessment of the MR system and software chain for data analysis. However, a wash-out of fixative fluid affecting T1 values and thus T1-weighted sequences such as magnetization-prepared 180 degrees radiofrequency pulses and rapid gradient-echo (MP-RAGE) has been reported for brain phantoms, hampering their immediate use. The purpose of this study was the creation of anatomical data that provide the characteristics of conventional data while avoiding this artifact. THEORY AND METHODS: Two brain phantoms were scanned at several time points, acquiring conventional MP-RAGE data and quantitative T1 and proton density (PD) maps. Assuming a suitable cutoff value T1cut , synthetic MP-RAGE data were created from these maps, being T1-weighted for T1 > T1cut to reduce fluid signal in the sulci, but PD-weighted for T1 < T1cut for artifact suppression. RESULTS: A time-dependent artifact was observed in the T1 but not in the PD maps. The temporal stability of the synthetic data was greatly improved as compared to the conventional data. CONCLUSION: The proposed method enables anatomical imaging of postmortem brain phantoms, avoiding artifacts induced by the wash-out of fixative fluid, and thus achieving high signal stability shortly after fixation. Magn Reson Med 77:1115-1123, 2017. © 2016 International Society for Magnetic Resonance in Medicine.