Survival of retained permanent canines after autotransplantation: A retrospective cohort study.

INTRODUCTION: After third molars, canines are the teeth most commonly affected by displacement and impaction. Although orthodontic surgical treatment represents the standard method for realignment of canines, autotransplantation (autoTX) functions as the second-line therapy if orthodontic alignment does not succeed in treating impaction and severe displacement. This retrospective cohort study aimed to identify clinical predictors for postoperative survival and endodontic treatment needs after autoTX of severely displaced and impacted canines. METHODS: The study cohort comprised patients who received canine autoTX in a single surgical center between 2006 and 2018. Canines with severe displacement and retention were surgically treated using a standardized protocol. Statistical analysis of survival probability was performed with the Kaplan-Meier method, and bivariate data were analyzed using logistic regression and the Pearson chi-square test. Nonparametric continuous variables were analyzed using the Mann-Whitney U test. RESULTS: Data from 319 patients with 378 canine grafts were available for analysis after a mean follow-up of 54.7 ± 36.5 months on the patient level (range, 0.3-181.8 months). With 25 lost autotransplants, the cumulative survival rate was 93.4%. Patient age at surgery, the state of the apical foramen, endodontic treatment need, and persistence of deciduous teeth at the implantation site had a significant negative impact on autotransplant survival (P <0.05). Endodontic treatment need was significantly related to the patient's age at surgery, the state of the apical foramen, and preoperative orthodontic traction (P <0.05). Thus, these independent variables were identified as clinical predictors for the survival of both the autotransplant and the dental pulp. Gender, ischemia time, postoperative ankylosis, or site of autoTX did not influence any of the outcome variables. CONCLUSIONS: The high survival rates of autotransplanted permanent canines make this treatment a promising option, especially in patients with severe tooth displacement, in which orthodontic treatment alone cannot provide predictable alignment, irrespective of the patient's age. Interpreting age and preoperative orthodontic traction as delaying the onset of autoTX and state of apex, time-dependent aspects seem to be of great importance for postoperative complications leading to endodontic treatment or graft loss. Therefore, early implementation of autoTX as a treatment modality for impacted, severely displaced, and vain exposed canines in daily surgical practice should be encouraged.

Long term outcomes of en-block autotransplantation of a tooth.

Repositioning of impacted teeth in the dental arch through en-bloc autotransplantation showed short-term efficacy of 89%. The objective of this study was to evaluate the technique for long-term efficacy. The analysis involved 23 teeth transplanted to the alveolar ridge through harvesting the tooth with the adjacent bone tissue. Development of the root was completed and the apical foramen was closed in all the teeth. The teeth were examined clinically and radiologically (CBCT) and compared to contralateral ones. The obtained data were analysed statistically. The efficacy of the procedure amounted to 81% including two teeth lost at an early stage and another two lost during follow-up. The mean age of patients upon performing the procedure was 29.8. The long-term follow-up amounted to the mean of 34.3 months. In the study group recession of 1-2 mm as well as 3-5 mm was found, which was not noted on the control group. In 11.1% of the study group teeth the external root resorption was observed. No transplanted tooth underwent root canal treatment, no periapical changes were observed at CBCT and 77.8% of those showed positive reaction to ethyl chloride. One case of ankylosis was observed in tooth 11 and in two cases increased mobility of the transplanted tooth was found. Regeneration of nerves as well as revascularization in the en-bloc autotransplantation proceeded with high predictability and the risk of ankylosis of the treated tooth seemed to be negligible. Gingival recession was observed more often in case of en-bloc transplantation compared to the control group. The long-term follow-up suggested that this the technique does not prevent external resorption in 100%.

[Bilateral autogenous transplantation of impacted maxillary canines]. / Bilaterale autologe transplantatie van geïmpacteerde maxillaire cuspidaten.

In a fifteen-year-old girl, bilaterally impacted permanent maxillary canines were established. A difficult palatinal placement and an apical deviation were found in both teeth. Surgical exposure of the canines, followed by orthodontic traction was not desirable. Both remaining primary canines showed signs of resorption. Autogenous transplantation of the maxillary canines was the treatment chosen.

Autogenous transalveolar transplantation of maxillary canines: a systematic review and meta-analysis.

Background and objectives: The objective was to systematically review transalveolar transplantation of maxillary canines and the long-term outcome for an average follow-up period of 2 years or more. Data collection and analysis: A systematic review of the currently available literature until December 2017 was conducted, using Medline, Cochrane Central, Web off Science, and PubMed. Articles were screened for 1. indications, 2. contra-indications, 3. surgical planning, 4. surgical technique, 5. associated risk factors, and 6. long-term outcome for transalveolar transplantation of maxillary canines with the following outcome measures: bone-related outcomes, tooth-related outcomes, soft tissue-related outcomes, and aesthetic outcome measures. Descriptive statistics, as well as a quality assessment of included articles, were performed. Following study retrieval and selection, relevant data was extracted and the risk of bias was assessed using the Methodological index for non-randomized studies (MINORS). Results: Twelve articles were included in this review. These studies included outcome data for 783 autotransplanted maxillary canines, with long-term studies indicating a clinically acceptable overall outcome. Limitations: Since the lack of randomized controlled trials considering this topic, the quality of the evidence in the present review is considered low. However, impacted maxillary canines are a rare anomaly and different aspects, such as position of the impacted canine, patient's age and patient's demands, and expectancies must be taken into account, it is practically impossible to randomize treatment. Conclusions: There is sufficient evidence to justify the transalveolar transplantation of maxillary canines as a legitimate treatment technique for impacted maxillary canines deemed difficult to treat with surgical exposure and subsequent orthodontic alignment. Long-term studies have shown that a good overall outcome is to be expected. There is no clear agreement in the literature on the indications and contra-indications for transalveolar transplantation of maxillary canines. Implication of key findings: It is highly desirable that further research on this issue be undertaken, high-quality observational studies are recommended. Registration: PROSPERO (CRD42017056348).

Autotransplantation: A Reliable Treatment Modality for Severely Malpositioned Teeth.

Maxillary canines are the most commonly impacted teeth, second only to third molars. Various treatment methods may be used to recover impacted maxillary canines. This is a report of a 14-year-old girl with a severely malpositioned impacted right maxillary canine which accompanied severe root resorption of adjacent tooth, treated by autotransplantation with a computer aided rapid prototyping model as a surgical guide. This case report demonstrates that autotransplantation can be a reliable treatment alternative, in cases with a severely malpositioned impacted canine, providing acceptable prognosis.

Clinical Management of Impacted and Transmigrated Lower Canines.

PURPOSE: Impacted, in particular transmigrated, lower canines are rare. If they transmigrate, then the most common treatment is extraction. Alternatively, the native tooth can be preserved; however, management is complex. This report describes a decision-making flowchart (DMFC) with surgical strategies for the management of impacted lower canines. MATERIALS AND METHODS: Fifty-six patients had impacted lower canines, of which 16 were transmigrated. A preliminary version of the DMFC was used for the development of treatment plans to decide which strategy to apply to these complex cases. After removal of associated pathologies (for experimental tooth-preserving therapies), miniscrews were used as transient skeletal anchorage devices (TADs). The TADs allowed a closed surgical approach for impacted and transmigrated lower canine eruption. For autotransplantation, a dummy tooth was used for socket preparation to minimize the period of no blood supply to the graft. RESULTS: After surgical exposure and TAD insertion, orthodontic treatment was performed in 4 patients. One patient was selected for successful autotransplantation. Nine patients had the transmigrated canines surgically removed. The remaining patients opted for "leave and observe." Based on the satisfactory long-term results with orthodontic treatment and autotransplantation and on published reports, the resulting DMFC presents key aspects of the treatment plan, namely 1) associated pathology, 2) patient age, 3) compliance, and 4) root tip position. CONCLUSIONS: TAD-assisted orthodontic treatment and autotransplantation of impacted lower canines are tooth-preserving alternatives to extraction. The developed DMFC assists the complex treatment planning of impacted and transmigrated lower canines.

Guided tooth autotransplantation of a palatally impacted maxillary canine into the site of a failed maxillary canine implant.

The aim of this report is to demonstrate the guided tooth autotransplantation of a palatally impacted maxillary canine into the site of a failed maxillary canine dental implant. A 47-year-old woman visited a dental clinic complaining of loose dental implant in the left maxillary canine site, tooth #11, as well as pain and swelling of the gum around the implant. The clinical examination revealed a mobile implant along with swollen soft tissues with bleeding on probing. A periapical radiograph demonstrated peri-implant marginal bone loss. Cone beam computed tomography sections revealed that tooth #11 was impacted palatally. The implant was removed and replaced with the impacted canine via guided autotransplantation and posterior orthodontic alignment. The patient was recalled at 1, 3, 6, 9, 12, 24 and 48 months after the procedure. During this period, the patient was symptom-free and radiographic examination at 2 years revealed no periapical pathosis or root resorption.

Canine autotransplantation: effect of extraction site preservation with a titanium prosthesis and a bioresorbable membrane.

The permanent canine is the most frequently displaced or impacted tooth. The standard treatment for an impacted canine includes surgical exposure and orthodontic alignment. Autotransplantation is a treatment alternative for canines with complete root formation. The purpose of this article is to report a canine autotransplantation where the extraction site was preserved with a titanium prosthesis and a bioresorbable membrane. The autotransplanted canine had minimal root resorption and no ankylosis.

Impacted maxillary canine on the position of the central incisor: surgical-orthodontic repositioning.

The aim of this article is to describe a case of a young orthodontic patient in which an impacted maxillary canine was repositioned in the central incisor position. A severe resorption of the root of the central right maxillary incisor by ectopic eruption of the impacted right maxillary canine is described. The canine was repositioned in the incisor's position to avoid resorption of the roots of the adjacent teeth during the disinclusion. The central incisor was extracted and the canine was extruded by a closed eruption technique. When the canine eruption was complete, the tip, the torque and the morphology of the canine were modified in order to make it look like an incisor. Nowadays the therapy with dental implants is the best choice, if the position of impacted teeth is difficult to reach. This case report describes a successful management of an impacted upper right canine aligned in the upper right central incisor position. Accurate diagnosis, conservative management of the soft tissues, anchorage unit and the direction of the orthodontic traction are important factors for the success treatment.

Treatment for critically impacted maxillary canines: Clinical versus scientific evidence - A systematic review.

BACKGROUND: Critically impacted maxillary canines are prone to fail to respond to conventional surgical exposure and orthodontic traction. Correct identification of a critical impaction requires enhanced diagnosis modalities and might lead to incorporating alternative surgical strategies in the treatment plan. Predictability of techniques such as apicotomy or tooth autotransplantation is, however, yet to be determined. The objective of this study was to systematically review treatment perspectives for critically impacted maxillary canines. METHODS: A systematic review of the available literature until april 2020 was conducted using an electronic search in Embase, Cochrane Central, Web of Science and PubMed databases. Randomised and non-randomised studies investigating treatment options and treatment outcome for buccally and/or palatally critically impacted maxillary canines were considered for the review. Information recorded concerned study design and setting, participants' characteristics and details regarding the type of intervention, types of outcomes measured and follow-up time. The included studies received a methodological quality scoring and risk of bias analysis according to a tool suggested by Murad et al (2018). RESULTS: Five studies were included in the quality analysis, all case series. The included studies enrolled a total of 302 patients and counted 346 critical maxillary canine impactions. Apicotomy and autotransplantation were listed as potential surgical approaches with surgical outcome presented for both surgical strategies. Adequate esthetical and/or functional outcomes were reported in most of the included studies. According to the quality assessment tool used, the reviewed studies scored medium on the proposed scale. DISCUSSION: Literature featuring protocols for identifying and treating critical maxillary canine impaction only consists of case series and case reports, which provide low level of evidence. The rather good results reported by the reviewed studies must be put into perspective as the methodology of these studies was insufficient and potential bias was identified. Comprehensive clinical research is needed to further investigate treatment options and form a basis for clinical guidelines.

Survival and success of maxillary canine autotransplantation: a retrospective investigation.

The aim of this study was to evaluate survival and success rates following autotransplantation of permanent maxillary canine teeth. Sixty-three cases of maxillary canine autotransplantation from 49 subjects (mean age at transplantation 21.8 years, range 13-42.1 years) undertaken between 1977 and 2003 were collected as part of an audit project of transplantation success. All maxillary canines had complete root development at the time of transplantation. The sample was divided into two groups, a matched case-control study to compare 27 unilateral transplanted canines with the non-transplanted canine on the contralateral side, and all 63 transplanted canines with no controls. Teeth were assessed clinically using established criteria for success: tooth presence for survival and resorption, mobility, probing pocket depth (PPD), gingival bleeding, vitality, and colour. Radiographic investigation for success assessed internal and external inflammatory resorption (including the amount) bone levels and any signs of pathology. Data were described with descriptive statistics and analytical tests were used to assess frequencies of occurrence. The survival rate was 83 per cent with an average duration of 14.5 years in situ. Thirty-eight per cent of the transplants were deemed successful. There were statistically significant associations between the transplanted and non-transplanted teeth in PPD (P = 0.006), gingival bleeding (P = 0.006), vitality (P = 0.004), and colour (P = 0.002). Autotransplantation of impacted maxillary canines can be successful in the long term and may be indicated in selected cases. Although the rate for complete success in this study was low (no signs of resorption, mobility, and sound periodontal tissues), the survival rate can be considered favourable when evaluating autotransplantation as a treatment option for grossly malpositioned canines with little scope for orthodontic alignment.

Long-term follow up of clinical outcome of orthodontic tooth movement following extraction of previously auto-transplanted maxillary canines and bone grafting: a case report.

BACKGROUND: The present case is a 13-year follow up of a patient in which the treatment plan involved removal of unsatisfactory auto-transplanted maxillary canines together with a bone graft to re-establish normal dento-alveolar ridge morphology. Active tooth movement occurred in the graft site. At the time, this was a new approach and there was no information in the literature as to the outcome of this treatment modality. Long-term reports regarding the success of this treatment are lacking. AIMS: To assess the long-term outcome of active tooth movement into a site that required bone grafting. METHODS: The upper right canine was non-vital with poor periodontal support on its buccal aspect. Examination revealed a substantial bony defect with a loss of the buccal cortical plate following extraction. To augment the ridge defect bone was taken from the maxillary tuberosity and grafted in the upper right canine extraction site and fixed with a bone screw. Protraction of the first premolar and retraction of the lateral incisor into the graft site was slow and constant. RESULTS: Significant closure of the upper canine extraction space was achieved. There were no significant detrimental bone changes in the interproximal areas of 14 and 12. CONCLUSION: By employing a bone graft to reestablish alveolar bone prior to tooth movement, excellent bone support, periodontal health and a long-term stable result were obtained.

Autotransplantation of teeth in 215 patients. A follow-up study.

OBJECTIVE: To evaluate the success rate of autotransplantation of teeth in consecutive patients and to analyze factors affecting the outcome. MATERIALS AND METHODS: The subjects consisted of 215 consecutive patients (101 women and 114 men; aged 9.1-56.4 years, median age 15.2 years [P(10) = 11.4, P(90) = 19.7]) who had undergone transplantation of a total of 269 teeth, all by the same surgeon. In patients with multiple transplants, only the first transplant was included, to ensure that all transplanted teeth were independent units. The transplants were recorded as unsuccessful if the tooth had been extracted or was surviving but with root resorption or ankylosis. The interval between transplantation and final follow-up was a median 4.8 years (P(10) = 2.0, P(90) = 5.5) for successful transplants and a median of 2.4 years (P(10) = 0.4, P(90) = 7.7) for unsuccessful transplants. RESULTS: One-hundred seventy-five (81%) of the transplantations were recorded as successful and 40 (19%) as unsuccessful. Twenty-five teeth had been extracted and 15 had survived but did not fulfill the criteria for success. CONCLUSIONS: The success rate of 215 consecutively transplanted teeth was 81%. The highest success rate was for transplantation of premolars to the maxillary incisor region (100%). Complications at surgery such as difficult extraction, deviant root anatomy, or damaged root periodontium affected the outcome. During growth, a successful transplant preserves alveolar bone.

Long-term outcome of autogenously transplanted maxillary canines.

The aim of this study was to determine the long-term outcome of autotransplanted maxillary canines and to investigate the influencing parameters. Seventy-one patients (84 transplanted canines) volunteered to participate in this study. The mean follow-up time was 21 years. In case of tooth survival and when patients were found willing for recall, teeth were investigated clinically and radiographically. Transplanted teeth were compared to the contralateral canine and scored with an aesthetic and radiographic index. The survival rate was 67.9%, considering that 27 transplanted teeth were lost before examination. The mean survival time was 15.8 years. Maxillary canine autotransplantation may have a successful outcome up to 21 years after transplantation requiring minimal patient compliance and low financial costs. The survival rate can be considered favorable realizing that autotransplantation is a treatment option in a selected group of cases.

5-year longitudinal study of survival rate and periodontal parameter changes at sites of maxillary canine autotransplantation.

BACKGROUND: Although dental transplantation is an accepted treatment modality, few studies have evaluated the prognosis for autotransplantation of maxillary canines, and changes in clinical periodontal parameters still need to be demonstrated. The objectives of this long-term study were to evaluate the prognosis and changes in clinical attachment level (CAL), probing depth (PD), soft tissue recession (REC), and radiographic bone level changes between years 1 and 5 for autotransplanted maxillary canines. METHODS: Thirty subjects with 32 impacted canines were scheduled for transplantation. Transplanted teeth were splinted for 4 weeks, and endodontic treatments were performed within 1 year after the operation. Radiographs were taken, and PD and CAL were measured for up to 5 years. Progressive root resorption was observed in two teeth, and one tooth was extracted during year 4. RESULTS: The survival rate was 93.5%. CAL and PD tended to increase slightly at all sites, especially at palatal sites after transplantation, whereas the greatest CAL and PD were found at approximal sites, and REC was the same as natural teeth. CONCLUSIONS: Maxillary canine transplantation can be a reliable treatment alternative. Clinical measurements demonstrated long-term stability. Based on the literature and the present findings, maxillary canine transplantation can be suggested as a promising treatment modality.

Treatment of an avulsed maxillary permanent central incisor by autotransplantation of a primary canine tooth.

AIM: To present a case in which an avulsed permanent maxillary central incisor was replaced by autotransplantation of a primary canine tooth. SUMMARY: The present case describes transplantation of a primary canine tooth into the space left by an avulsed permanent maxillary central incisor after a delay of several days. After root canal treatment, the primary canine tooth was extracted and placed into the prepared socket. To provide better adaptation of the donor tooth, the recipient alveolar site was remodeled using surgical burs. Semi-rigid splinting was maintained for 15 days. The crown of the primary canine was reshaped with composite resin and with an interim prosthesis, preventing movement of the lateral incisor tooth into the space of the transplanted canine. After 24-month follow-up the autotransplanted primary canine showed ankylosis but the tooth was in an acceptable state. The use of permanent tooth autotransplantation has been well documented. However a literature search revealed only one case report on the autotransplantation of primary teeth. KEY LEARNING POINTS: Long term results of primary tooth autotransplantation are scarce but the procedure in this case report could be considered as a temporary space maintainer for the treatment of a patient with a lost permanent incisor under 10 years of age. Success of primary tooth autotransplantation may be affected by several factors, such as case selection, extra oral time, surgical and endodontic procedures.

Transplantation of primary canines after loss or ankylosis of upper permanent incisors. A prospective case series study on healing and survival.

Primary canines were transplanted to replace lost or ankylosed permanent upper incisors. Healing, healing complications and loss and survival were evaluated in a prospective case series study. In total, 27 primary canines were transplanted. Extraorally posts made of titanium were inserted into the root canal from a retrograde direction as an immediate endodontic treatment and as an elongation of the short autologous roots. In some cases antiresorptive-regenerative therapy was used. Inclusion criteria for the evaluation were a minimal observation period of 12 months or the observation of complications. The median observation period of the analyzed 17 transplants was 26.6 months (min: 6.7 months, max: 54.6 months). Sixteen out of seventeen transplants exhibited functional healing until the end of the observation or the occurrence of an external influence (another trauma, resorption by neighbored tooth). In no case ankylosis or arrest of alveolar growth was recorded. In some transplants resorptions not related to infection or ankylosis were observed. One transplant exhibited an early infection-related complication and was removed. One transplant was resorbed by the developing permanent canine and lost. Following another trauma five transplants were lost. External influence and new trauma were significantly related to the loss of transplants (Fisher's exact test; P = 0.0006 and 0.0034). The estimated survival according to a Kaplan-Meier analysis was 40.7 months for all transplants. It was significantly shorter for teeth which were lost in relation to an external influence (survival 28.4 months vs 44.7 months; log rank test: P = 0.0093). The transplantation of primary canines maintains bone and soft tissues of the alveolar process. The healing rate is high. However, there is a high incidence of repeated trauma episodes, causing a high loss rate. The observation period is still limited.

Clinical management of the congenitally missing maxillary lateral incisor and mandibular second premolar: a clinical perspective.

The decision to close maintain, or open space at the agenesis sites of the maxillary lateral incisor and mandibular second premolar is generally based on several factors, including the class of malocclusion, skeletal pattern (divergence), esthetics, function, and periodontics. Replacement of congenitally missing maxillary lateral incisors, the second most commonly missing teeth, can involve (1) canine replacement, (2) tooth-supported restoration, and (3) implants. This paper contrary to the opinion of other authors, favors replacement of the congenitally missing lateral incisors in one of several ways, versus orthodontic space closure.

Autogenous transplant of two impacted mandibular canines: a case report with 2-year follow-up.

PURPOSE: To present a case report of autogenous transplant of two impacted mandibular canines. MATERIALS AND METHODS: A 12-year-old girl, with vestibular impaction of mandibular left and right canines had them extracted and transplanted in the anatomically corrected sites, after an unsuccessful orthodontic treatment including surgical exposure. RESULTS: After 2 years the teeth are stable and their vitality is maintained. CONCLUSIONS: In this case the transplantation of the mandibular canines was successful and maintained the vitality of the transplanted teeth for at least 2 years. By preserving the periodontal ligament is it possible to re-establish a functional tooth unit, which allows a physiologic growth of the jaws.