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1.
Eur J Cancer ; 42(16): 2744-50, 2006 Nov.
Article in English | MEDLINE | ID: mdl-16950616

ABSTRACT

AIM: To analyse, for patients with carcinoma of the parotid gland, the prognostic value for treatment outcome of the function of the facial nerve (NVII), and determining facial nerve dysfunction after treatment. METHODS AND MATERIALS: In a retrospective study of the Dutch head and Neck cooperative group (NWHHT), data of 324 patients with parotid carcinoma were analysed. The function of N VII before treatment was intact in 77%, partially and completely impaired in 14% and 7%, respectively. Eighty-eight percent of the patients were treated surgically, and 77% of them were treated by a combination of postoperative radiotherapy. In 21% NVII was sacrificed, a reconstruction was performed in one of three. RESULTS: Independent risk factors for N VII dysfunction before treatment were tumour localisation, positive neck nodes at presentation, pain, increasing age, and perineural invasion. Regional, not local, control was significantly impaired for complete facial paralysis. N VII dysfunction was an independent factor for disease free survival, and was 69%, 37% and 13% for normal, partially and completely impaired function, respectively. After treatment 22% of the patients experienced a partial paralysis, and 13% of the patients experienced a complete paralysis of N VII. CONCLUSION: For patients with parotid carcinoma, facial nerve function before treatment is a strong prognostic factor for disease free survival.


Subject(s)
Facial Nerve Diseases/etiology , Facial Nerve/physiology , Parotid Neoplasms/physiopathology , Adolescent , Adult , Aged , Aged, 80 and over , Child , Disease-Free Survival , Facial Nerve Diseases/mortality , Facial Nerve Diseases/physiopathology , Female , Humans , Male , Middle Aged , Neoplasm Metastasis , Neoplasm Recurrence, Local/mortality , Parotid Neoplasms/mortality , Prognosis , Retrospective Studies , Treatment Outcome
2.
J Neurosurg ; 74(6): 910-5, 1991 Jun.
Article in English | MEDLINE | ID: mdl-2033451

ABSTRACT

In a series of over 500 cases of cerebellopontine angle tumors, 19 patients had bilateral neurinomas. Four of these tumors arose from the facial rather than the acoustic nerve. A conservative policy regarding surgery had been adopted in an effort to prevent hearing loss for as long as possible. Nevertheless, all patients operated on in this series are now totally deaf. The results of managing these patients surgically and conservatively are discussed.


Subject(s)
Cerebellar Neoplasms/surgery , Cerebellopontine Angle , Cranial Nerve Neoplasms/surgery , Facial Nerve Diseases , Facial Nerve Diseases/surgery , Neoplasms, Multiple Primary/surgery , Neuroma, Acoustic/surgery , Adult , Cerebellar Neoplasms/diagnosis , Cerebellar Neoplasms/mortality , Child , Cranial Nerve Neoplasms/diagnosis , Cranial Nerve Neoplasms/mortality , Deafness/etiology , Facial Nerve Diseases/diagnosis , Facial Nerve Diseases/mortality , Female , Hearing Loss/etiology , Humans , Male , Middle Aged , Neoplasms, Multiple Primary/diagnosis , Neoplasms, Multiple Primary/mortality , Neuroma, Acoustic/diagnostic imaging , Neuroma, Acoustic/mortality , Prognosis , Reoperation , Survival Rate , Tomography, X-Ray Computed
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