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1.
CA Cancer J Clin ; 71(1): 78-92, 2021 01.
Article in English | MEDLINE | ID: mdl-33002206

ABSTRACT

Cancer is a disease of aging and, as the world's population ages, the number of older persons with cancer is increasing and will make up a growing share of the oncology population in virtually every country. Despite this, older patients remain vastly underrepresented in research that sets the standards for cancer treatments. Consequently, most of what we know about cancer therapeutics is based on clinical trials conducted in younger, healthier patients, and effective strategies to improve clinical trial participation of older adults with cancer remain sparse. For this systematic review, the authors evaluated published studies regarding barriers to participation and interventions to improve participation of older adults in cancer trials. The quality of the available evidence was low and, despite a literature describing multifaceted barriers, only one intervention study aimed to increase enrollment of older adults in trials. The findings starkly amplify the paucity of evidence-based, effective strategies to improve participation of this underrepresented population in cancer trials. Within these limitations, the authors provide their opinion on how the current cancer research infrastructure must be modified to accommodate the needs of older patients. Several underused solutions are offered to expand clinical trials to include older adults with cancer. However, as currently constructed, these recommendations alone will not solve the evidence gap in geriatric oncology, and efforts are needed to meet older and frail adults where they are by expanding clinical trials designed specifically for this population and leveraging real-world data.


Subject(s)
Geriatrics/statistics & numerical data , Medical Oncology/statistics & numerical data , Neoplasms/therapy , Patient Participation/psychology , Patient Selection , Aged , Aged, 80 and over , Clinical Trials as Topic , Geriatrics/methods , Geriatrics/trends , Humans , Medical Oncology/methods , Medical Oncology/trends , Neoplasms/diagnosis , Patient Participation/statistics & numerical data , United States
2.
Med Care ; 60(1): 37-43, 2022 01 01.
Article in English | MEDLINE | ID: mdl-34812789

ABSTRACT

BACKGROUND: Hispanic older adults face substantial health disparities compared with non-Hispanic-White (hereafter "White") older adults. To the extent that these disparities stem from cultural and language barriers faced by Hispanic people, they may be compounded by residence in rural areas. OBJECTIVE: The objective of this study was to investigate possible interactions between Hispanic ethnicity and rural residence in predicting the health care experiences of older adults in the United States, and whether disparities in care for rural Hispanic older adults differ in Medicare Advantage versus Medicare Fee-for-Service. SUBJECTS: Medicare beneficiaries age 65 years and older who responded to the 2017-2018 nationally representative Medicare Consumer Assessment of Healthcare Providers and Systems (CAHPS) surveys. METHODS: We fit a series of linear, case-mix-adjusted models predicting Medicare CAHPS measures of patient experience (rescaled to a 0-100 scale) from ethnicity, place of residence, and Medicare coverage type. RESULTS: In all residential areas, Hispanic beneficiaries reported worse experiences with getting needed care (-3 points), getting care quickly (-4 points), and care coordination (-1 point) than White beneficiaries (all P's<0.001). In rural areas only, Hispanic beneficiaries reported significantly worse experiences than White beneficiaries on doctor communication and customer services (-3 and -9 points, respectively, P<0.05). Tests of a 3-way interaction between ethnicity, rural residence, and coverage type were nonsignificant. CONCLUSIONS: There is a need to improve access to care and care coordination for Hispanic beneficiaries overall and doctor-patient communication and customer service for rural Hispanic beneficiaries. Strategies for addressing deficits faced by rural Hispanics may involve cultural competency training and provision of language-appropriate services for beneficiaries (perhaps as telehealth services).


Subject(s)
Hispanic or Latino/statistics & numerical data , Medicare/statistics & numerical data , Quality of Health Care/standards , Aged , Aged, 80 and over , Female , Geriatrics/methods , Geriatrics/standards , Geriatrics/statistics & numerical data , Health Services Accessibility/standards , Health Services Accessibility/statistics & numerical data , Humans , Male , Patient Satisfaction , Quality of Health Care/statistics & numerical data , Rural Population/statistics & numerical data , United States , Urban Population/statistics & numerical data
3.
PLoS Biol ; 17(2): e3000148, 2019 02.
Article in English | MEDLINE | ID: mdl-30730879

ABSTRACT

Knowledge of true mortality trajectory at extreme old ages is important for biologists who test their theories of aging with demographic data. Studies using both simulation and direct age validation found that longevity records for ages 105 years and older are often incorrect and may lead to spurious mortality deceleration and mortality plateau. After age 105 years, longevity claims should be considered as extraordinary claims that require extraordinary evidence. Traditional methods of data cleaning and data quality control are just not sufficient. New, more strict methodologies of data quality control need to be developed and tested. Before this happens, all mortality estimates for ages above 105 years should be treated with caution.


Subject(s)
Demography/statistics & numerical data , Geriatrics/statistics & numerical data , Longevity/genetics , Mortality/trends , Aged, 80 and over , Data Accuracy , Female , Humans , Male , Quality Control
4.
J Med Virol ; 93(8): 5152-5157, 2021 08.
Article in English | MEDLINE | ID: mdl-33704814

ABSTRACT

In Europe, the respiratory syncytial virus (RSV) surveillance system is very heterogeneous and there is growing evidence of the importance of RSV infections resulting in hospitalization of elderly patients. The aim of this study was to assess the severity of RSV infection in the elderly living in the aged Southern European countries. We conducted a retrospective study of elderly patients ( ≥65-year old) admitted for laboratory-confirmed RSV infection in three tertiary hospitals in Portugal, Italy, and Cyprus over two consecutive winter seasons (2017-2018). Uni-multivariable analyses were carried out to evaluate the effect of clinical variables on radiologically confirmed pneumonia, use of noninvasive ventilation (NIV), and in-hospital death (IHD). A total of 166 elderly patients were included. Pneumonia was evident in 29.5%. NIV was implemented in 16.3%, length of stay was 11.8 ± 12.2 days, and IHD occurred in 12.1%. Multivariable analyses revealed that the risk of pneumonia was higher in patients with chronic kidney disease (CKD) (odds ratio [OR]: 2.57; 95% confidence interval [CI]: 1.12-5.91); the use of NIV was higher in patients with obstructive sleep apnea or obesity hypoventilation syndrome (OSA or OHS) (OR: 5.38; 95% CI: 1.67-17.35) and CKD (OR: 2.52; 95% CI: 1.01-6.23); the risk of IHD was higher in males (OR: 3.30; 95% CI: 1.07-10.10) and in patients with solid neoplasm (OR: 9.06; 95% CI: 2.44-33.54) and OSA or OHS (OR: 8.39; 95% CI: 2.14-32.89). Knowledge of factors associated with RSV infection severity may aid clinicians to set priorities and reduce disease burden. Development of effective antiviral treatment and vaccine against RSV is highly desirable.


Subject(s)
Geriatrics/statistics & numerical data , Respiratory Syncytial Virus Infections/epidemiology , Aged , Aged, 80 and over , Europe/epidemiology , Female , Hospital Mortality , Hospitalization , Humans , Male , Noninvasive Ventilation/statistics & numerical data , Pneumonia, Viral/diagnosis , Pneumonia, Viral/epidemiology , Pneumonia, Viral/therapy , Respiratory Syncytial Virus Infections/diagnosis , Respiratory Syncytial Virus Infections/therapy , Respiratory Syncytial Virus, Human/isolation & purification , Retrospective Studies , Risk Factors , Seasons , Tertiary Care Centers
5.
Int J Med Sci ; 18(16): 3744-3747, 2021.
Article in English | MEDLINE | ID: mdl-34790048

ABSTRACT

This study aimed to assess the incidence and associates of hypoglycemia in patients transferred after stabilization on an Acute Medical Unit to two general medical or two geriatric wards at an urban Australian hospital. In a six-month audit representing 20,284 patient-days of observation, 59 inpatients experienced hypoglycaemia (blood glucose ≤3.9 mmol/L) during 65 hospitalizations. Inpatients experiencing hypoglycemia accounted for 7.2% of all inpatient bed-days, a figure that was greater for general medical (9.2% of bed-days) compared with geriatric (6.0% of bed-days) wards (P<0.001). Inpatient hypoglycemia often had no precipitant such as a missed/delayed meal, occurred disproportionately at night (41% of episodes), was severe (blood glucose ≤3.0 mmol/L) in one-third of cases, and appeared more frequent in patients with psychiatric/cognitive issues. These data highlight the ongoing issue of hypoglycemia in relatively stable inpatients in an era of blood glucose-lowering therapies associated with a low rate of this acute metabolic complication.


Subject(s)
Geriatrics/statistics & numerical data , Hospitalization/statistics & numerical data , Hypoglycemia/epidemiology , Adult , Aged , Aged, 80 and over , Australia/epidemiology , Clinical Audit , Critical Illness/epidemiology , Critical Illness/therapy , Female , Hospital Units/statistics & numerical data , Hospitals, General/statistics & numerical data , Humans , Incidence , Inpatients/statistics & numerical data , Intensive Care Units/statistics & numerical data , Male , Middle Aged , Prospective Studies , Time Factors
6.
Am J Emerg Med ; 49: 153-157, 2021 Nov.
Article in English | MEDLINE | ID: mdl-34116468

ABSTRACT

OBJECTIVE: Copeptin, reflecting vasopressin release, as well as the National Early Warning Score (NEWS), reflecting the severity of critical illness, might qualify for survival prediction in elderly patients with critical illness. This prospective observational study aims at assessing the predictive value of copeptin combined with NEWS on the prognosis of elderly critical ill patients at emergency department (ED). METHODS: We analyzed serum copeptin levels and the NEWS at admission to the ED in a prospective, single-center, and observational study comprising 205 elderly patients with critical illness. Death within 30 days after admission to the ED was the primary end point. RESULTS: The serum copeptin levels and the NEWS in the non-survivor patients group were higher than those in the survivor group [30.35 (14.20, 38.91) vs 17.53 (13.01, 25.20), P = 0.001 and 9.0 (7.0-10.0) vs 7.0 (6.0-8.0), P = 0.001]. Multivariate logistic regression analysis showed that copeptin, NEWS and copeptin combined with NEWS were all independent risk factors for 30-day mortality in elderly patients with critical illness. Copeptin, NEWS and copeptin combined with NEWS all performed well in predicting 30-day survival, with area under the ROC curve (AUC) values of 0.766 (95%CI, 0.702-0.822), 0.797 (95%CI, 0.744-0.877) and 0.854 (95%CI, 0.798-0.899) respectively. Using the Z test to compare the areas under the above three curves, copeptin combined with NEWS showed a higher predictive value for 30-day survival (P < 0.05). As we calculated, the optimal cut-off values of copeptin and NEWS using the Youden index were 19.78 pg/mL and 8.5 points, respectively. Risk stratification analysis showed that patients with both copeptin levels higher than 19.78 pg/mL and NEWS points higher than 8.5 points had the highest risk of death. CONCLUSIONS: Copeptin combined with NEWS have a stronger predictive power on the prognosis of elderly patients with critical illness at ED, comparing to either factor individually.


Subject(s)
Critical Illness/mortality , Glycopeptides/analysis , Survival Analysis , Aged , Aged, 80 and over , Area Under Curve , Critical Illness/epidemiology , Early Warning Score , Emergency Service, Hospital/organization & administration , Female , Geriatrics/methods , Geriatrics/statistics & numerical data , Hospitalization/statistics & numerical data , Humans , Logistic Models , Male , Prognosis , Prospective Studies , ROC Curve , Tertiary Care Centers/organization & administration , Tertiary Care Centers/statistics & numerical data
7.
Home Health Care Serv Q ; 40(1): 93-104, 2021.
Article in English | MEDLINE | ID: mdl-32990180

ABSTRACT

Nowadays, as life expectancy grows, the healthcare industry faces growing challenges related to corresponding increases in chronic diseases. Home care services (HCS) are the solution to this growing problem. It's a general premise that information and communication technology (ICT) can address these health issues and enhances HCS. The scope of our study was the active managerial and supervisory roles of these technologies within HCS. The study aimed to extract, accumulate, and classify the challenges of using active ICT for elderly HCS. We employed the keywords, their synonyms, and their combinations into the searching areas of title, keywords, and abstract. More than 300 resources were collected, and found those 33 articles of those 33 articles were eligible for our study. Later, a team of experts provided their opinions on our gatherings, which were collected individually. According to the expert team's opinions, researchers classified challenges into; technology, human factors, and management.


Subject(s)
Geriatrics/instrumentation , Home Care Services/trends , Telemedicine/statistics & numerical data , Geriatrics/methods , Geriatrics/statistics & numerical data , Home Care Services/organization & administration , Home Care Services/statistics & numerical data , Humans , Information Technology/trends , Telemedicine/methods
8.
J Tissue Viability ; 30(1): 108-115, 2021 Feb.
Article in English | MEDLINE | ID: mdl-33485786

ABSTRACT

BACKGROUND: Nursing home residents are vulnerable to chronic wounds. However, the prevalence data are scarce. AIM: The purpose of this study was to determine the prevalence of pressure ulcers and/or leg ulcers in nursing home residents, and describe the characteristics of the nursing homes, the residents and the wounds, as well as possible associations between these characteristics. METHODS: This was a cross-sectional survey of nursing home residents over the age of 65 in 168 facilities in Barcelona. Those presenting category II-IV pressure ulcers and/or leg ulcers were included. The data were collected by observation/examination. Descriptive, bivariate, and multivariate analyses were performed. RESULTS: The overall prevalence of pressure ulcers and leg ulcers combined was 4.4% (3.5% were pressure ulcers and 0.9% were leg ulcers). In small nursing homes with less nursing staff, the overall prevalence was greater than in large nursing homes (5.6% vs 3.8% [p = 0.01]). As expected, residents with pressure ulcers had higher pressure ulcer risk, worse dependence and cognitive status, urinary and faecal incontinence, and most were underweight. However, residents with leg ulcers had worse venous and arterial impairment and also were overweight. A multivariate analysis showed that pressure ulcers were statistically significantly associated with faecal incontinence (OR = 0.28, 95% CI = 0.09-0.81) and dyslipidaemia (OR = 0.21, 95% CI = 0.06-0.66), and leg ulcers were statistically significantly associated with venous insufficiency (OR = 4.93, 95% CI = 1.65-15.34). The characteristics of gluteal and ischial pressure ulcers, a high prevalence of infection, and a low reference to biofilm by nurses, in both types of wounds, suggest that these aspects are not adequately taken into account. CONCLUSIONS: Pressure ulcers and leg ulcers, mainly pressure ulcers, remain a public health problem in nursing homes. Further studies are required to confirm the associations found in this study.


Subject(s)
Geriatrics/statistics & numerical data , Pressure Ulcer/classification , Aged , Aged, 80 and over , Analysis of Variance , Chi-Square Distribution , Cross-Sectional Studies , Female , Geriatrics/methods , Humans , Male , Nursing Homes/organization & administration , Nursing Homes/statistics & numerical data , Pressure Ulcer/epidemiology , Prevalence , Risk Factors , Spain/epidemiology
9.
Eur J Clin Microbiol Infect Dis ; 39(11): 2085-2090, 2020 Nov.
Article in English | MEDLINE | ID: mdl-32594325

ABSTRACT

SARS-CoV-2 dramatically revealed the sudden impact of respiratory viruses in our lives. Influenza and respiratory syncytial virus (RSV) infections are associated with high rates of morbidity, mortality, and an important burden on healthcare systems worldwide, especially in elderly patients. The aim of this study was to identify severity predictors in the oldest-old admitted with influenza and/or RSV infections. This is a multicenter, retrospective study of all oldest-old patients (≥ 85 years old) admitted for laboratory-confirmed influenza and/or RSV infection in three tertiary hospitals in Portugal, Italy, and Cyprus over two consecutive winter seasons. The outcomes included the following: pneumonia on infection presentation, use of non-invasive ventilation (NIV), and in-hospital death (IHD). The association with possible predictors, including clinical features and type of virus infection, was assessed using uni- and multivariable analyses. A total of 251 oldest-old patients were included in the study. Pneumonia was evident in 32.3% (n = 81). NIV was implemented in 8.8% (n = 22), and IHD occurred in 13.9% (n = 35). Multivariable analyses revealed that chronic obstructive pulmonary disease (COPD) or asthma was associated with pneumonia (OR 1.86; 95% CI 1.02-3.43; p = 0.045). COPD or asthma (OR 4.4; 95% CI 1.67-11.6; p = 0.003), RSV (OR 3.12; 95% CI 1.09-8.92; p = 0.023), and influenza B infections (OR 3.77; 95% CI 1.06-13.5; p = 0.041) were associated with NIV use, respectively, while chronic kidney disease was associated with IHD (OR 2.50; 95% CI 1.14-5.51; p = 0.023). Among the oldest-old, chronic organ failure, such as COPD or asthma, and CKD predicted pneumonia and IHD, respectively, beyond the importance of viral virulence itself. These findings could impact on public health policies, such as fostering influenza immunization campaigns, home-based care programs, and end-of-life care. Filling knowledge gaps is crucial to set priorities and advise on transition model of care that best fits the oldest-old.


Subject(s)
Geriatrics/statistics & numerical data , Influenza, Human/epidemiology , Respiratory Syncytial Virus Infections/epidemiology , Aged, 80 and over , Europe/epidemiology , Female , Hospital Mortality , Humans , Influenza, Human/therapy , Male , Noninvasive Ventilation/statistics & numerical data , Pneumonia, Viral/epidemiology , Pneumonia, Viral/therapy , Respiratory Syncytial Virus Infections/therapy , Retrospective Studies , Seasons , Tertiary Care Centers
10.
Am J Emerg Med ; 38(4): 780-784, 2020 04.
Article in English | MEDLINE | ID: mdl-31272756

ABSTRACT

PURPOSE: The quick Sepsis-Related Organ Failure Assessment (qSOFA) score was designed to predict mortality among sepsis patients. However, it has never been used to identify prolonged length of hospital stay (pLOS) in geriatric patients with influenza infection. We conducted this study to clarify this issue. METHODS: We conducted a retrospective case-control study, including geriatric patients (aged ≥ 65 years) with influenza infection visiting the emergency department (ED) of a medical center between January 01, 2010 and December 31, 2015. The included patients were divided into two groups on the basis of their qSOFA score: qSOFA < 2, and qSOFA ≥ 2. Data regarding demographics, vital signs, qSOFA score, underlying diseases, subtypes of influenza, and outcomes were included in the analysis. We investigated the association between qSOFA score ≥ 2 and pLOS (>9 days) via logistic regression. RESULTS: Four hundred and nine geriatric patients were included in this study with a mean age of 79.5 (standard deviation [SD], 8.3) years. The median length of stay (LOS) was 7.0 (interquartile range [IQR], 4-12) days, while the rate of pLOS (> 9 days) was 32%. The median LOS in the qSOFA ≥ 2 group, 11.0 (7-15) days, was longer than the qSOFA < 2 group, 6.0 (4-10) days (p-value <0.01). Logistic regression showed that qSOFA ≥ 2 predicts pLOS with an odds ratio of 3.78 (95% confidence interval, 2.04-6.97). CONCLUSION: qSOFA score ≥ 2 is a prompt and simple tool to predict pLOS in geriatric patients with influenza infection.


Subject(s)
Geriatrics/instrumentation , Influenza, Human/complications , Length of Stay/statistics & numerical data , Organ Dysfunction Scores , Aged , Aged, 80 and over , Female , Geriatrics/methods , Geriatrics/statistics & numerical data , Humans , Influenza, Human/epidemiology , Influenza, Human/physiopathology , Male , Retrospective Studies , Severity of Illness Index , Taiwan/epidemiology
11.
BMC Palliat Care ; 19(1): 109, 2020 Jul 20.
Article in English | MEDLINE | ID: mdl-32690071

ABSTRACT

BACKGROUND: In ageing Western societies, many older persons live with and die from cancer. Despite that present-day healthcare aims to be patient-centered, scientific literature has little knowledge to offer about how cancer and its treatment impact older persons' various outlooks on life and underlying life values. Therefore, the aims of this paper are to: 1) describe outlooks on life and life values of older people (≥ 70) living with incurable cancer; 2) elicit how healthcare professionals react and respond to these. METHODS: Semi-structured qualitative interviews with 12 older persons with advanced cancer and two group interviews with healthcare professionals were held and followed by an analysis with a grounded theory approach. RESULTS: Several themes and subthemes emerged from the patient interview study: a) handling incurable cancer (the anticipatory outlook on "a reduced life", hope and, coping with an unpredictable disease) b) being supported by others ("being there", leaving a legacy, and having reliable healthcare professionals) and; c) making end-of-life choices (anticipatory fears, and place of death). The group interviews explained how healthcare professionals respond to the abovementioned themes in palliative care practice. Some barriers for (open) communication were expressed too by the latter, e.g., lack of continuity of care and advance care planning, and patients' humble attitudes. CONCLUSIONS: Older adults living with incurable cancer showed particular outlooks on life and life values regarding advanced cancer and the accompanying last phase of life. This paper could support healthcare professionals and patients in jointly exploring and formulating these outlooks and values in the light of treatment plans.


Subject(s)
Attitude to Death , Neoplasms/psychology , Social Values , Aged , Aged, 80 and over , Female , Geriatrics/methods , Geriatrics/statistics & numerical data , Humans , Interviews as Topic/methods , Male , Neoplasms/mortality , Qualitative Research , Quality of Health Care/standards , Quality of Health Care/statistics & numerical data
12.
J Med Libr Assoc ; 108(1): 59-66, 2020 Jan.
Article in English | MEDLINE | ID: mdl-31897052

ABSTRACT

OBJECTIVE: This bibliometric study investigated literature pertaining to a quickly growing population worldwide: the oldest-old, individuals age eighty-five and older. The current state of research was surveyed, based on top authors, publishers, authorship networks, themes in publication titles and abstracts, and highly cited publications. METHODS: Bibliographic data was abstracted from the Web of Science database. Microsoft Excel was used for data analyses related to top author, publishers, and terms. VosViewer bibliographic visualization software was used to identify authorship networks. RESULTS: Publications pertaining to the oldest-old have increased dramatically over the past three decades. The majority of these publications are related to medical or genetics topics. Citations for these publications remain relatively low but may be expected to grow in coming years, based on the publication behavior about and increasing prominence of this population. Claudio Franceschi and the Journal of the American Geriatrics Society were found to be the author and journal with the most publications pertaining to the oldest-old, respectively. CONCLUSIONS: The oldest-old is a population of rapidly growing significance. Researchers in library and information science, gerontology, and beyond can benefit themselves and those they serve by participating in research and specialized services to marginalized populations like the oldest-old. This bibliometric study hopefully serves as a launch-point for further inquiry and research in the years to come.


Subject(s)
Abstracting and Indexing/statistics & numerical data , Authorship , Biomedical Research/statistics & numerical data , Frail Elderly/statistics & numerical data , Geriatrics/statistics & numerical data , Publications/statistics & numerical data , Publishing/statistics & numerical data , Aged, 80 and over , Bibliometrics , Female , Humans , Male
13.
J Community Health Nurs ; 37(4): 179-188, 2020.
Article in English | MEDLINE | ID: mdl-33150809

ABSTRACT

Fall injuries are the leading cause of injury death in older adults, yet despite this, health-care providers do not routinely incorporate fall prevention into practice. A fall prevention training program was developed for non-clinical caregivers serving community-dwelling older adults using the CDC's STEADI tool. The project outcomes revealed statistically significant increases in items related to knowledge and confidence in fall risk and assessment. Findings could guide the development of fall prevention training programs targeted at non-clinical caregivers to community-dwelling older adults.


Subject(s)
Accidental Falls/prevention & control , Caregivers/education , Geriatrics/methods , Accidental Falls/statistics & numerical data , Adult Day Care Centers/organization & administration , Adult Day Care Centers/statistics & numerical data , Caregivers/standards , Caregivers/statistics & numerical data , Geriatrics/education , Geriatrics/statistics & numerical data , Humans , Independent Living/education , Independent Living/statistics & numerical data , Self Efficacy , Surveys and Questionnaires
14.
Adv Gerontol ; 33(2): 391-396, 2020.
Article in Russian | MEDLINE | ID: mdl-32593258

ABSTRACT

The article analyzes the situation with the development of gerontology in the Kyrgyz Republic. The long-term process of the formation of the gerontological service in the country and its achievements are described in detail. The positive fact is that not only international organizations, but also the state and society itself began to pay attention to the problem of older people. Despite the certain and achieved successes in the development of the service, problems are indicated that require urgent measures to resolve, especially the development of the geriatric service, which today does not meet the modern challenges of aging. The important role of creating the gerontology institute, as a coordinating body in the training of specialized personnel, in the development and implementation of cooperated scientific research and the implementation of their results in healthcare practice was emphasized.


Subject(s)
Delivery of Health Care/statistics & numerical data , Geriatrics/statistics & numerical data , Humans , Kyrgyzstan/epidemiology
15.
Oncologist ; 24(8): 1089-1094, 2019 08.
Article in English | MEDLINE | ID: mdl-30710065

ABSTRACT

BACKGROUND: The objective of this study was to describe the implementation of comprehensive geriatric assessment (CGA) in clinical trials dedicated to older patients before and after the creation of the International Society of Geriatric Oncology in the early 2000s. SUBJECTS, MATERIALS, AND METHODS: All phase I, II, and III trials dedicated to the treatment of cancer among older patients published between 2001 and 2004 and between 2011 and 2014 were reviewed. We considered that a CGA was performed when the authors indicated an intention to do so in the Methods section of the article. We collected each geriatric domain assessed using a validated tool even in the absence of a clear CGA, including nutritional, functional, cognitive, and psychological status, comorbidity, comedication, overmedication, social status and support, and geriatric syndromes. RESULTS: A total of 260 clinical trials dedicated to older patients were identified over the two time periods: 27 phase I, 193 phase II, and 40 phase III trials. CGA was used in 9% and 8% of phase II and III trials, respectively; it was never used in phase I trials. Performance status was reported in 67%, 79%, and 75% of phase I, II, and III trials, respectively. Functional assessment was reported in 4%, 11%, and 13% of phase I, II, and III trials, respectively. Between the two time periods, use of CGA increased from 1% to 11% (p = .0051) and assessment of functional status increased from 3% to 14% (p = .0094). CONCLUSION: The use of CGA in trials dedicated to older patients increased significantly but remained insufficient. IMPLICATIONS FOR PRACTICE: This article identifies the areas in which research efforts should be focused in order to offer physicians well-addressed clinical trials with results that can be extrapolated to daily practice.


Subject(s)
Clinical Trials as Topic/statistics & numerical data , Geriatric Assessment/statistics & numerical data , Geriatrics/trends , Medical Oncology/trends , Neoplasms/therapy , Age Factors , Aged , Aged, 80 and over , Clinical Decision-Making/methods , Female , Frailty/diagnosis , Frailty/etiology , Geriatrics/methods , Geriatrics/statistics & numerical data , Humans , Karnofsky Performance Status , Male , Medical Oncology/methods , Medical Oncology/statistics & numerical data , Middle Aged , Neoplasms/complications , Neoplasms/diagnosis , Prognosis , Retrospective Studies
16.
Curr Oncol Rep ; 21(8): 69, 2019 06 25.
Article in English | MEDLINE | ID: mdl-31240413

ABSTRACT

PURPOSE OF REVIEW: Breast cancer incidence and mortality increase with age. Older patients (≥ 70) are often excluded from studies. Due to multiple factors, it is unclear whether this population is best-treated using standard guidelines. Here, we review surgical management in older women with breast cancer. RECENT FINDINGS: Geriatric assessments can guide treatment recommendations and aid in predicting survival and quality of life. Surgery remains a principal component of breast cancer treatment in older patients, though differences exist compared with younger women, including higher mastectomy rates and evidence-based support of omission of post-lumpectomy radiation or axillary dissection in subsets of patients. In those forgoing surgical management, there is increased use of endocrine therapy. Hospice is also a valuable element of end-of-life care. Physicians should utilize geriatric assessment to make treatment recommendations for older breast cancer patients, including omission of radiation therapy, alterations to standard surgeries, or enrollment in hospice care.


Subject(s)
Breast Neoplasms/surgery , Geriatric Assessment , Aged , Antineoplastic Agents, Hormonal/therapeutic use , Breast Neoplasms/drug therapy , Breast Neoplasms/mortality , Female , Geriatrics/standards , Geriatrics/statistics & numerical data , Hospice Care , Humans , Mastectomy , Medical Oncology/standards , Medical Oncology/statistics & numerical data
17.
Age Ageing ; 48(3): 458-462, 2019 05 01.
Article in English | MEDLINE | ID: mdl-30624577

ABSTRACT

INTRODUCTION: national reports highlight deficiencies in the care of older patients undergoing surgery. A 2013 survey showed less than a third of NHS trusts had geriatrician-led perioperative medicine services for older surgical patients. Barriers to establishing services included funding, workforce and limited interspecialty collaboration. Since then, national initiatives have supported the expansion of geriatrician-led services for older surgical patients.This repeat survey describes geriatrician-led perioperative medicine services in comparison with 2013, exploring remaining barriers to developing perioperative medicine services for older patients. METHODS: an electronic survey was sent to clinical leads for geriatric medicine at 152 acute NHS healthcare trusts in the UK. Reminders were sent on four occasions over an 8-week period. The survey examined the nature of the services provided, extent of collaborative working and barriers to service development. Responses were analysed descriptively. RESULTS: eighty-one (53.3%) respondents provide geriatric medicine services for older surgical patients, compared to 38 (29.2%) in 2013. Services exist across surgical specialties, especially in orthopaedics and general surgery. Fourteen geriatrician-led preoperative clinics now exist. Perceived barriers to service development remain workforce issues and funding. Interspecialty collaboration has increased, evidenced by joint audit meetings (33% from 20.8%) and collaborative guideline development (31% from 17%). CONCLUSION: since 2013, an increase in whole-pathway geriatric medicine involvement is observed across surgical specialties. However, considerable variation persists across the UK with scope for wider adoption of services facilitated through a national network.


Subject(s)
Health Services for the Aged , Perioperative Care , Aged , Critical Pathways , Geriatrics/methods , Geriatrics/statistics & numerical data , Humans , Perioperative Care/methods , Perioperative Care/statistics & numerical data , State Medicine , Surgical Procedures, Operative , Surveys and Questionnaires , United Kingdom
18.
J Emerg Med ; 57(4): 535-542, 2019 Oct.
Article in English | MEDLINE | ID: mdl-31353267

ABSTRACT

BACKGROUND: It is documented that health professionals from various settings fail to detect > 50% of delirium cases. OBJECTIVE: This study aimed to describe the proportion of unrecognized incident delirium in five emergency departments (EDs). Secondary objectives were to compare the two groups (recognized/unrecognized) and assess the impact of unrecognized delirium at 60 days regarding 1) unplanned consultations and 2) functional and cognitive decline. METHOD: This is a sub-analysis of a multicenter prospective cohort study. Independent patients aged ≥ 65 years who tested negative for delirium on the initial interview with an ED stay ≥ 8 h were enrolled. Patients were assessed twice daily using the Confusion Assessment Method (CAM) and the Delirium Index up to 24 h into hospital admission. Medical records were reviewed to assess whether delirium was recognized or not. RESULTS: The main study reported a positive CAM in 68 patients. Three patients' medical files were incomplete, leaving a sample of 65 patients. Delirium was recognized in 15.4% of our participants. These patients were older (p = 0.03) and female (p = 0.01) but were otherwise similar to those with unrecognized delirium. Delirium Index scores were higher in patients with recognized delirium (p = 0.01) and they experienced a more important functional decline at 60 days (p = 0.02). No association was found between delirium recognition and health care services utilization or decline in cognitive function. CONCLUSIONS: This study confirms reports of high rates of missed or unrecognized delirium (84.6%) in ED patients compared to routine structured screening using the CAM performed by a research assistant. Patients with recognized delirium were older women with a greater severity of symptoms and experienced a more significant functional decline at 60 days.


Subject(s)
Delirium/diagnosis , Geriatrics/standards , Aged , Aged, 80 and over , Cohort Studies , Delirium/physiopathology , Delirium/psychology , Emergency Service, Hospital/organization & administration , Emergency Service, Hospital/statistics & numerical data , Female , Geriatric Assessment/methods , Geriatrics/methods , Geriatrics/statistics & numerical data , Humans , Male , Prospective Studies , Risk Factors
19.
Rev Epidemiol Sante Publique ; 67(3): 169-174, 2019 May.
Article in French | MEDLINE | ID: mdl-30853146

ABSTRACT

INTRODUCTION: Frailty is a complex concept that can be assessed with multiple instruments. Its assessment has often been implemented in hospitals. However, first-line prevention of the frailty syndrome is paramount in general medicine. The aim of the study was to test the feasibility and the concordance of two instruments for assessing frailty and to test the adequacy between the level of frailty and the presence of caregivers. METHODS: We conducted a descriptive, analytical cross-sectional study in Reims during two months. Patients included were 65 and older. Second consultations were not retained. We collected the patients' the SEGA and Fried scores as well as the opinions of the doctor and the resident student on the presence of frailty and the presence or not of home-help. RESULTS: There was an excellent concurrence between the doctor's assessment and the SEGA score (Kappa=0.89) and a moderate concurrence with the Fried score (Kappa=0.46) compared to 0.95 and 0.50 respectively for the resident student's assessment. The agreement between the assessments of the resident student and the doctor was excellent (Kappa=0.95) the concurrence between frailty and the home-helpers showed that when patients displayed frailty symptoms home-helpers were absent in 69.6% of the cases, but planned in 82.6%. CONCLUSION: To conclude, in general medicine, there is no reference score for fraily assessment, whereas the SEGA score is easy to use and reproducible. It can be used as a score of reference for patient assessment and monitoring.


Subject(s)
Frailty/diagnosis , General Practice/standards , Geriatric Assessment/methods , Geriatrics/standards , Aged , Aged, 80 and over , Cross-Sectional Studies , Feasibility Studies , Female , Frail Elderly/statistics & numerical data , Frailty/epidemiology , France/epidemiology , General Practice/methods , General Practice/statistics & numerical data , Geriatrics/methods , Geriatrics/statistics & numerical data , Humans , Male , Reference Standards
20.
J Cancer Educ ; 34(1): 9-13, 2019 02.
Article in English | MEDLINE | ID: mdl-28646457

ABSTRACT

Currently, there is no formal curriculum addressing geriatric oncology within Canadian radiation oncology (RO) residency programs. Knowledge related to geriatric medicine may help radiation oncologists modify RT based on frailty status and geriatric considerations. Understanding specific learning needs allow program coordinators to align the current curriculum with residents' geriatric oncology learning needs. The purpose of this study is to determine the geriatric oncology educational needs of the Canadian RO residents and to inform Canadian RO residency training. A cross-sectional survey, with Likert, multiple choice, and open-ended questions, was pretested and distributed electronically by program directors to Canadian RO residents over 6 weeks. Responses were analyzed with descriptive statistics and common themes. One-hundred and thirty-five Canadian RO residents were contacted and 63 responded (47%). Half (49%) lacked confidence managing the elderly with multiple comorbidities, polypharmacy, functional and cognitive impairment, and challenging social circumstances;73% agreed additional training would be helpful. Forty-four percent lacked confidence regarding psychogeriatric referrals, fall prevention, palliative and hospice care, and community resources preventing re-hospitalization; 63% agreed additional training would be helpful. Seventy-six percent believed discussion groups, continuing education, geriatric oncology electives, and journal clubs would provide learning opportunities. Seventy-one percent agreed integrating geriatric assessment into RO curricula would improve care. Seventy-nine percent believed geriatric oncology principles have not been adequately integrated into radiation oncology curricula. There are significant gaps specific to geriatric assessment and management of older cancer patients in the current Canadian RO curricula. Most residents agreed that it is important to integrate geriatric oncology training to improve and personalize the care of older cancer patients.


Subject(s)
Curriculum/standards , Geriatrics/education , Internship and Residency/organization & administration , Needs Assessment/statistics & numerical data , Neoplasms/radiotherapy , Radiation Oncology/education , Surveys and Questionnaires , Aged , Canada , Clinical Competence , Cross-Sectional Studies , Geriatric Assessment , Geriatrics/statistics & numerical data , Health Knowledge, Attitudes, Practice , Humans
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