Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 308
Filter
Add more filters

Publication year range
1.
BMC Oral Health ; 23(1): 229, 2023 04 20.
Article in English | MEDLINE | ID: mdl-37081478

ABSTRACT

BACKGROUND: To analyze the clinicopathological features of different histological subtypes of epulis, and evaluate the risk factors associated with recurrence. MATERIALS AND METHODS: A retrospective study including 2971 patients was performed. The patients' sex, age, location, size, histological subtypes, recurrence information, oral hygiene habits, periodontitis symptoms and smoking history were retrieved from the patient medical records and follow-up information. RESULTS: Among the 2971 cases, focal fibrous hyperplasia (FFH) was the most common lesion (60.92%), followed by peripheral ossifying fibroma (POF) (29.32%), pyogenic granuloma (PG) (8.08%) and peripheral giant cell granuloma (PGCG) (1.68%). The peak incidence of epulis was in the third and fourth decade of life, with a mean age of 45.55 years. Female predominance was found in all types of lesions with a female to male ratio of 1.71:1. PG had the highest recurrence rate (17.18%), followed by POF (12.98%), FFH (9.55%) and PGCG (8.82%). Histological subtypes were significantly correlated with the recurrence of epulis (P = 0.013). Regular supportive periodontal therapy (P = 0.050) had a negative correlation with recurrence, whereas symptoms of periodontitis (P < 0.001) had a positive correlation with the recurrence of epulis. CONCLUSIONS: Controlling the periodontal inflammation and regular supportive periodontal therapy might help reduce the recurrence of epulis.


Subject(s)
Calcinosis , Fibroma, Ossifying , Gingival Diseases , Gingival Neoplasms , Granuloma, Giant Cell , Granuloma, Pyogenic , Humans , Male , Female , Middle Aged , Cohort Studies , Retrospective Studies , Gingival Diseases/epidemiology , Gingival Neoplasms/pathology , Fibroma, Ossifying/diagnosis , Fibroma, Ossifying/epidemiology , Fibroma, Ossifying/pathology , Granuloma, Giant Cell/epidemiology , Granuloma, Giant Cell/pathology , Risk Factors , Granuloma, Pyogenic/epidemiology , Granuloma, Pyogenic/pathology , Hyperplasia
2.
BMC Oral Health ; 21(1): 265, 2021 05 17.
Article in English | MEDLINE | ID: mdl-34001082

ABSTRACT

BACKGROUND: While inflammatory diseases such as gingivitis and periodontitis induced by dental plaque biofilms constitute the majority of gingival lesions, gingiva can also be affected by a variety of diseases with aetiologies different from bacterial biofilms. The aim of this study was to retrospectively analyze the frequency and distribution of non-dental plaque-induced gingival diseases (NDPIGDs) in the Chinese population in a single institute. METHODS: A total of 6859 samples of biopsied gingival diseases during the period 2000-2019 were obtained from the Department of Pathology, Peking University Hospital of Stomatology. Lesions were categorized by histopathological diagnosis, pathological characteristics and the new classification of gingival health and gingival diseases/conditions. Demographic information, such as gender, location, and age, were also analyzed. RESULTS: Among 6859 biopsied NDPIGD samples, the five most frequent diagnoses included oral squamous cell carcinoma (OSCC, n = 2094), fibrous hyperplasia (n = 2026), pyogenic granuloma (n = 478), epithelial dysplasia (n = 477), and epithelial hyperplasia/hyperkeratosis (n = 436). All types could be grouped into nine categories according to their pathological characteristics. The most common biopsied NDPIGDs category was "hyperplastic lesions" (n = 2648, 38.61%), followed by "malignant neoplasms" (n = 2275, 33.17%). The most common diagnosis types in each category were fibrous hyperplasia and OSCC. Of all NDPIGDs, most lesions could be categorized into the new classification of gingival health and gingival diseases/conditions; only 7.07% did not fit the current classification system. CONCLUSIONS: The present study is the first report on the frequency and distribution of biopsied NDPIGDs in a Chinese population. Unlike previous studies, the most prevalent categories were "hyperplastic lesions" and "malignant neoplasms". The proportion of "malignant neoplasms" and "oral potentially malignant disorders" was remarkably higher than in previous researches. Nevertheless, the study provided epidemiological information on many NDPIGDs, which could be useful for future health policies as well as screening programs.


Subject(s)
Carcinoma, Squamous Cell , Gingival Diseases , Gingivitis , Mouth Neoplasms , China/epidemiology , Gingival Diseases/epidemiology , Gingival Diseases/etiology , Humans , Retrospective Studies
3.
Acta Odontol Scand ; 77(8): 608-616, 2019 Nov.
Article in English | MEDLINE | ID: mdl-31230511

ABSTRACT

Objective: The objective of this study is to study the association of alcoholic beverages and serum gamma-glutamyltransferase (GGT) level with periodontal condition. Material and methods: The study included 4294 dentate, non-diabetic Finnish adults aged 30-65 years who underwent periodontal examination during the Health 2000 Survey. The number of teeth with deepened (≥4 mm) periodontal pockets was the outcome. The exposures were self-reported beverage-specific alcohol intake (amount and frequency) and serum GGT level. The relative risks (RRs) and 95% confidence intervals (CI) were obtained by fitting zero-inflated negative binomial regression models. Results: We found no consistent association of either the intake of different alcoholic beverages or GGT level with the number of teeth with deepened periodontal pockets in the total study population or among the non-smokers. Among the highly educated non-smokers, spirit intake was associated with a low likelihood of having teeth with deepened periodontal pockets; RRs varied between 0.3 and 0.8. Among the non-smokers who had basic or intermediate education, spirit intake was associated with a higher likelihood of having teeth with deepened periodontal pockets; RRs varied between 1.2 and 1.8. Conclusion: In general, neither the intake of different alcoholic beverages nor the GGT level was consistently associated with the number of teeth with deepened periodontal pockets.


Subject(s)
Alcohol Drinking/epidemiology , Gingival Diseases , Periodontal Diseases , Adult , Aged , Alcoholic Beverages/statistics & numerical data , Beverages , Female , Finland , Gingival Diseases/epidemiology , Health Status , Health Surveys , Humans , Male , Middle Aged , Periodontal Diseases/epidemiology , Periodontal Pocket
4.
BMC Oral Health ; 19(1): 234, 2019 11 01.
Article in English | MEDLINE | ID: mdl-31675959

ABSTRACT

BACKGROUND: Good oral health has been associated with better quality of life and general health. In the Caribbean, there have been no studies regarding the association between oral health conditions and the quality of life of the population. The main purpose of this study was to investigate the association between gingival parameters and oral health-related quality of life (OHRQoL) in Caribbean adults. A secondary aim of the study was to gain more information on factors that impact OHRQoL in this population. METHODS: This cross-sectional, epidemiological, population-based study was conducted in community settings. After the participants with missing Oral Health Impact Profile (OHIP) data were excluded, the sample size was 1821 (weighted according to the age and gender distribution in each target population). OHIP-14 standardized questionnaires were used to collect information. In addition, a medical/oral health questionnaire including sociodemographics, general health, dental visits, oral hygiene habits and knowledge, the frequency of dental visits, prosthesis use/hygiene, and smoking was administered. A multivariate model included predictors that showed significant associations in the univariate models. Odds ratios (ORs) and 95% confidence intervals (CIs) were reported; statistical significance was set at 0.05. RESULTS: In the multivariate analysis, current smokers (OR = 2.34, 95% CI: 1.74-3.14 vs. never smokers), those who visited the dentist only when problems arose (OR = 1.65, 95% CI: 1.13-2.40 vs. those visiting once a year), and participants with any chronic disease/condition (OR = 1.38, 95% CI: 1.06-1.78) had higher odds of being in the highest tertile for OHIP score (poorer health). CONCLUSIONS: The present multicenter study identified potential modifiable risk factors for poor OHRQoL among adults in three Caribbean cities.


Subject(s)
Gingival Diseases/epidemiology , Oral Health , Oral Hygiene , Population Surveillance/methods , Quality of Life , Adolescent , Adult , Aged , Caribbean Region/epidemiology , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Periodontal Index , Surveys and Questionnaires , Young Adult
5.
J Intellect Disabil Res ; 62(3): 187-198, 2018 03.
Article in English | MEDLINE | ID: mdl-29114946

ABSTRACT

BACKGROUND: Several risk factors for cardiovascular disease (CVD) have been identified among adults with intellectual disabilities (ID). Periodontitis has been reported to increase the risk of developing a CVD in the general population. Given that individuals with ID have been reported to have a higher prevalence of poor oral health than the general population, the purpose of this study was to determine whether adults with ID with informant reported gum disease present greater reported CVD than those who do not have reported gum disease and whether gum disease can be considered a risk factor for CVD. METHODS: Using baseline data from the Longitudinal Health and Intellectual Disability Study from which informant survey data were collected, 128 participants with reported gum disease and 1252 subjects without reported gum disease were identified. A series of univariate logistic regressions was conducted to identify potential confounding factors for a multiple logistic regression. RESULTS: The series of univariate logistic regressions identified age, Down syndrome, hypercholesterolemia, hypertension, reported gum disease, daily consumption of fruits and vegetables and the addition of table salt as significant risk factors for reported CVD. When the significant factors from the univariate logistic regression were included in the multiple logistic analysis, reported gum disease remained as an independent risk factor for reported CVD after adjusting for the remaining risk factors. Compared with the adults with ID without reported gum disease, adults in the gum disease group demonstrated a significantly higher prevalence of reported CVD (19.5% vs. 9.7%; P = .001). CONCLUSION: After controlling for other risk factors, reported gum disease among adults with ID may be associated with a higher risk of CVD. However, further research that also includes clinical indices of periodontal disease and CVD for this population is needed to determine if there is a causal relationship between gum disease and CVD.


Subject(s)
Cardiovascular Diseases/epidemiology , Gingival Diseases/epidemiology , Intellectual Disability/epidemiology , Adolescent , Adult , Aged , Aged, 80 and over , Cardiovascular Diseases/etiology , Comorbidity , Female , Gingival Diseases/complications , Health Surveys , Humans , Longitudinal Studies , Male , Middle Aged , Midwestern United States/epidemiology , Risk Factors , Young Adult
6.
BMC Oral Health ; 18(1): 112, 2018 06 19.
Article in English | MEDLINE | ID: mdl-29921254

ABSTRACT

BACKGROUND: Many gingival lesions are not induced by plaque. The aim of this study was to analyze the frequency of biopsied non-plaque-induced gingival lesions (NPIGL) in a Chilean population. METHODS: One thousand twelve cases of biopsied gingival lesions with confirmed anatomopathologic diagnosis were included, from the records of the Oral Pathology Referral Institute (OPRI), Faculty of Dentistry, University of Chile, between years 1990 and 2009. RESULTS: The most frequent non plaque-induced gingival lesions categories from biopsied cases included hyperplastic lesions, malignancies and benign neoplasms. The most frequent diagnoses in each category were fibrous hyperplasia (35.47%), squamous cell carcinoma (3.85%) and giant cell fibroma (2.08%), respectively. From all lesions, only 8.3% fitted in the specified categories of the current classification of periodontal diseases. CONCLUSIONS: The most frequent biopsied NPIGL were hyperplastic lesions and neoplasms. These categories represent relevant lesions to be included in a future periodontal classification system to improve the care needs of the patients, as well as early diagnosis and treatment.


Subject(s)
Gingival Diseases/epidemiology , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Biopsy , Carcinoma, Squamous Cell/diagnosis , Carcinoma, Squamous Cell/epidemiology , Carcinoma, Squamous Cell/etiology , Carcinoma, Squamous Cell/pathology , Child , Child, Preschool , Chile/epidemiology , Female , Gingiva/pathology , Gingival Diseases/diagnosis , Gingival Diseases/etiology , Gingival Diseases/pathology , Gingival Hyperplasia/diagnosis , Gingival Hyperplasia/epidemiology , Gingival Hyperplasia/etiology , Gingival Hyperplasia/pathology , Gingival Neoplasms/diagnosis , Gingival Neoplasms/epidemiology , Gingival Neoplasms/etiology , Gingival Neoplasms/pathology , Humans , Infant , Infant, Newborn , Male , Middle Aged , Periodontal Diseases/classification , Periodontal Diseases/epidemiology , Periodontal Diseases/etiology , Retrospective Studies , Young Adult
7.
Acta Derm Venereol ; 96(1): 92-6, 2016 Jan.
Article in English | MEDLINE | ID: mdl-26014511

ABSTRACT

Vulvovaginal-gingival lichen planus (VVG-LP) consists of a triad of symptoms: vulval, vaginal and gingival lichen planus lesions. The aim of this study was to analyse the prevalence of lesions in various anatomical locations in patients with VVG-LP. The study included 126 consecutive patients with lichen planus. Sixteen (12.7%) patients fulfilled the criteria of VVG-LP. In 12/16 (75%) patients with VVG-LP scalp lesions were also observed. Stratified epithelium-specific antinuclear antibodies (SES-ANA) and anti-ΔNp.3α antibodies were detected in 10/16 (75%) patients with VVG-LP and in 15/110 (13.6%) patients with other forms of lichen planus (p < 0.05). In conclusion, VVG-LP is frequently associated with lichen planopilaris. The new entity may be termed "vulvovaginal-gingival-pilar lichen planus" and our study indicates that SES-ANA is a marker of this type of lichen planus with extensive, severe and refractory-to-therapy involvement of the mucous membranes, skin and scalp.


Subject(s)
Antibodies, Antinuclear/analysis , Epithelial Cells/immunology , Gingival Diseases/immunology , Lichen Planus, Oral/immunology , Vaginal Diseases/immunology , Vulvar Diseases/immunology , Adult , Aged , Antibodies, Antinuclear/blood , Biomarkers/analysis , Biopsy , Enzyme-Linked Immunosorbent Assay , Female , Fluorescent Antibody Technique , Gingival Diseases/diagnosis , Gingival Diseases/epidemiology , Humans , Lichen Planus, Oral/diagnosis , Lichen Planus, Oral/epidemiology , Middle Aged , Poland/epidemiology , Prevalence , Terminology as Topic , Vaginal Diseases/diagnosis , Vaginal Diseases/epidemiology , Vulvar Diseases/diagnosis , Vulvar Diseases/epidemiology , Young Adult
8.
Eur J Paediatr Dent ; 17(1): 9-16, 2016 Mar.
Article in English | MEDLINE | ID: mdl-26949233

ABSTRACT

AIM: To evaluate the oral condition and treatment needs of young athletes with intellectual disability (ID) from 53 countries of Europe and Eurasia who participated in the Special Olympics European Games held in Antwerp, October 2014. METHODS: A cross- sectional study was undertaken with data collected through standardised procedures from consenting athletes under 21 years of age. Oral hygiene habits, reports of oral pain and presence of gingival signs, sealants, untreated caries and missing teeth were recorded. STATISTICS: Data analysis was performed in SPSS to produce descriptive statistics and explanatory variables for untreated decay, and gingival signs of disease were tested with Multilevel Generalized Linear Mixed Models. RESULTS: Five hundred three athletes participated in this study (mean age 17 yrs). Untreated decay was recorded in 33.4% of the participants and 38.7% of them had signs of gingival disease. Absence of untreated decay was associated with lower chances of gingival signs, while absence of sealants was related with higher chances of untreated decay. CONCLUSIONS: There is consistent evidence of persistent need for increased promotion of oral health, as well as preventive and restorative treatment in young athletes with ID in Europe and Eurasia. Due to the limited predictive capacity of the studied variables for oral disease, further studies including other related factors are needed.


Subject(s)
Athletes/statistics & numerical data , Intellectual Disability/epidemiology , Mouth Diseases/epidemiology , Needs Assessment/statistics & numerical data , Adolescent , Asia, Central/epidemiology , Child , Cross-Sectional Studies , Dental Caries/epidemiology , Dental Restoration, Permanent/statistics & numerical data , Europe/epidemiology , Female , Forecasting , Gingival Diseases/epidemiology , Global Health/statistics & numerical data , Humans , Linear Models , Male , Middle East/epidemiology , Pit and Fissure Sealants/therapeutic use , Tooth Loss/epidemiology , Toothache/epidemiology , Toothbrushing/statistics & numerical data , Young Adult
9.
Bull Tokyo Dent Coll ; 57(3): 175-81, 2016.
Article in English | MEDLINE | ID: mdl-27665695

ABSTRACT

The purpose of this study based on a cross-sectional internet survey was to investigate the relationship between risk of obstructive sleep apnea (OSA) and self-assessed oral health status. The participants, who comprised individuals registered with an online research company, were required to complete a self-reported questionnaire. Those answering in the affirmative to both of the following two questions were placed in the OSA-risk group, while those answering in the negative were assigned to the control group: 'Have other people noticed pauses in your breathing while you are sleeping?' and 'Do you feel excessively sleepy during the daytime?'. A total of 493 were included in the OSA-risk group and 2,560 in the control group. Among the total 3,053 respondents, the highest prevalence for OSA risk in men was in the 50-59-year age range, although this tended to level off after age 60 years. No such trend was observed in women, however. Multiple logistic regression analysis was performed to identify the relationship between risk of OSA and self-assessed oral health status. Significant correlations were observed with the following parameters: difficulty in opening mouth (odds ratio [OR]: 2.66; 95% confidence interval [CI]: 1.647-4.311), dry mouth (OR: 2.11; CI: 1.544-2.876), bad breath (OR: 1.69; CI: 1.309-2.186), gingival bleeding (OR: 1.48; CI: 1.134-1.932), and gingival swelling (OR: 1.44; CI: 1.046-1.981). These results suggest a relationship between risk of OSA and self-assessed oral health status, indicating that treating OSA might improve oral health status. Further study is needed to demonstrate a causal relationship between OSA and self-assessed oral health status, however.


Subject(s)
Oral Health/statistics & numerical data , Sleep Apnea, Obstructive/epidemiology , Adult , Age Factors , Aged , Body Mass Index , Cross-Sectional Studies , Dental Health Surveys/methods , Diagnostic Self Evaluation , Female , Gingival Diseases/epidemiology , Gingival Hemorrhage/epidemiology , Halitosis/epidemiology , Humans , Hypertension/epidemiology , Internet , Male , Middle Aged , Sex Factors , Tooth Mobility/epidemiology , Xerostomia/epidemiology
10.
BMC Oral Health ; 15(1): 117, 2015 Oct 08.
Article in English | MEDLINE | ID: mdl-26449516

ABSTRACT

BACKGROUND: The Dai people are one of the ethnic minorities in China and have a population of 1,260,000. They have the same origin as one of the main ethnic groups in Laos and Thailand. The study aims to describe the dental caries and gingival status of 12-year-old Dai children in China and to study the factors affecting their oral-health status. METHODS: This cross-sectional oral-health survey was conducted from 2011-2012 with ethics approval. A sample of 12-year-old Dai children living in Yunnan, China, was selected using a multistage and cluster sampling method. One trained examiner performed the clinical examination. Caries experience was measured using DMFT index, and gingival status was assessed with CPI index. A self-completed questionnaire was sent to the children, and they were asked about their backgrounds and oral-health-related behaviors and oral-health knowledge. Binary logistic regression analysis was performed to investigate the factors that affected the caries status. RESULTS: A total of 875 children were invited, and 823 (94 %) joined the survey. The prevalence of caries experience among the participants was 40 %. The mean DMFT and DT scores were 0.9 and 0.8, respectively. Most children (93 %) had gingivitis, and many (46 %) had calculus. Girls and those who had visited a dentist during the previous year had a higher prevalence of caries. CONCLUSION: Dental caries were prevalent among 12-year-old Dai children in China. The periodontal condition of most of the children was poor. Caries were associated with gender and dental attendance.


Subject(s)
Dental Caries , Gingival Diseases , Periodontal Diseases , Child , China , Cross-Sectional Studies , Dental Caries/epidemiology , Dental Health Surveys , Female , Gingival Diseases/epidemiology , Humans , Male , Minority Groups , Oral Health , Periodontal Diseases/epidemiology , Prevalence
11.
Oral Health Prev Dent ; 12(2): 99-107, 2014.
Article in English | MEDLINE | ID: mdl-24624383

ABSTRACT

PURPOSE: No nationwide oral health survey has previously been carried out in Jordan. The aims of the study were to assess the burden of dental caries and gingival health among children aged 6 and 12 years in relation to sociodemographic factors and to ascertain the trend over time in the occurrence of caries and the need for dental care. MATERIALS AND METHODS: A cross-sectional epidemiological survey was carried out which included 2496 children aged 6 years and 2560 children aged 12 years selected by stratified cluster sampling. Children were examined in schools and data comprised information about caries and gingival health status. WHO methodology and criteria were applied. Structured questionnaires were used to collect information about oral hygiene, dental visits, consumption of sugars and parents' level of education. RESULTS: The caries prevalence rates were 76.4% in 6-year-olds and 45.5% in 12-year-olds, and caries experience was 3.3 dmft and 1.1 DMFT, respectively. The prevalence of caries varied significantly by sex and geographical region. In both age groups, children of the social low and middle groups had significantly higher levels of caries experience, more untreated decayed teeth and fewer filled teeth than did children of the upper socioeconomic group. Multivariate regression analysis showed that social class was the most important independent variable for caries. The results from 2005 were compared with similar data collected in the capital, Amman, in 1993. For all social classes, the mean caries experience and the amount of untreated dental caries increased over time. Moreover, 17.7% of 6-year-old children and 49.1% of the 12-year-olds had gingival bleeding. Significant differences in gingival health were found by sex, location, geographical areas and socioeconomic group. CONCLUSION: Oral disease is a significant public health problem in Jordan. Strengthening of the school oral health programme is needed for effective prevention and control of caries and promoting gingival health. A systematic school oral health programme including oral health promotion should be established.


Subject(s)
Dental Caries/epidemiology , Oral Health/statistics & numerical data , Child , Cross-Sectional Studies , DMF Index , Dental Care/statistics & numerical data , Dental Restoration, Permanent/statistics & numerical data , Dietary Carbohydrates/administration & dosage , Educational Status , Epidemiologic Studies , Female , Gingival Diseases/epidemiology , Gingival Hemorrhage/epidemiology , Humans , Jordan/epidemiology , Male , Needs Assessment/statistics & numerical data , Oral Hygiene/statistics & numerical data , Parents/education , Prevalence , Sex Factors , Social Class , Urban Health/statistics & numerical data , Vulnerable Populations/statistics & numerical data
12.
J Med Assoc Thai ; 97 Suppl 10: S75-81, 2014 Oct.
Article in English | MEDLINE | ID: mdl-25816541

ABSTRACT

BACKGROUND: Although many complications from kidney disease therapy can be prevented or effectively treated, oral health problems are nevertheless a consequence. OBJECTIVE: The objective of this study was to explore the prevalence of enamel defect and gingival enlargement in pediatric patients with kidney disease at Srinagarind Hospital, Khon Kaen University, Thailand. MATERIAL AND METHOD: This cross-sectional study was conducted between January and August 2013, at SrinagarindHospital, Khon Kaen University. Ninety-seven pediatric patients with kidney disease were allowed by their parents to participate in this study. Data were collected from medical records, questionnaires and oral examination records. The enamel defect was recorded using the Developmental Defects of Enamel Index. Gingival enlargement was recorded using the GingivalEnlargement Index. An oral examination was conducted using a mouth mirror, explorer and periodontal probe. RESULTS: The average age of the pediatric patients with kidney disease was 11.53+3.7years (range, 4-17). The majority of subjects were able to (a) come for an appointment (97.9%), (b) take medication according to the medical directions (93.8%) and (c) avoid inappropriatefoodsfor those suffering kidney disease (84.5%). The prevalence of enamel defect was 27.8%. The most common enamel defects were demarcated opacities (13.4%) or diffuse opacities (9.3%). The prevalence ofgingival enlargement was 16.5%. CONCLUSION: This study revealed that the prevalence ofenamel defect was 27.8% and the prevalence ofgingival enlargement was 16.5%.


Subject(s)
Dental Enamel/pathology , Gingival Diseases/epidemiology , Kidney Diseases/epidemiology , Tooth Diseases/epidemiology , Academic Medical Centers , Adolescent , Child , Child, Preschool , Female , Gingival Diseases/complications , Gingival Diseases/pathology , Humans , Kidney Diseases/complications , Kidney Diseases/pathology , Male , Thailand/epidemiology , Tooth Diseases/complications , Tooth Diseases/pathology
13.
Front Endocrinol (Lausanne) ; 15: 1367607, 2024.
Article in English | MEDLINE | ID: mdl-39239094

ABSTRACT

Prior research has indicated that bisphosphonates (BPs) can improve periodontal disease because of their anti-osteoporosis properties. In vitro studies have shown that BPs induce cytotoxicity, inhibit wound healing, and thus affect periodontal disease. Denosumab and BPs have alternative indications. BP and denosumab are not known to correlate with gingival disorders. We assessed such a relationship by applying Bayesian and nonproportional analyses to data in the US FDA Adverse Event Reporting System (FAERS) database. The study analyzed BPs and denosumab-reported incidents with preferred terms found in the narrow Standardized MedDRA Queries for gingival disorders. A total of 5863 reported cases of gingival disorders were associated with five BPs (alendronate, pamidronate, ibandronate, risedronate, and zoledronate) and denosumab. More than 15% of patients with gingival disorders related to BPs and denosumab other than denosumab were hospitalized over short- or long-term periods. Our findings indicated BPs and denosumab had significant reporting odds ratios (ROR), proportional reporting ratios (PRR), and information components (IC) with respect to gingival disorders. Pamidronate had the highest association (ROR = 64.58, PRR = 57.99, IC = 5.71), while the weakest association was found with denosumab (ROR = 3.61, PRR = 3.60, IC = 1.77). Significant associations were found between the six drugs and gingival pain, gingival recession, gingivitis, periodontal disease, and periodontitis. In conclusion, our comprehensive overview of the correlations, clinical characteristics, and prognoses of BPs and denosumab-related gingival disorders suggests that these issues deserve continued surveillance and appropriate management.


Subject(s)
Adverse Drug Reaction Reporting Systems , Denosumab , Diphosphonates , Gingival Diseases , United States Food and Drug Administration , Humans , Adverse Drug Reaction Reporting Systems/statistics & numerical data , United States/epidemiology , Diphosphonates/adverse effects , Denosumab/adverse effects , Gingival Diseases/chemically induced , Gingival Diseases/epidemiology , Female , Bone Density Conservation Agents/adverse effects , Male , Middle Aged , Aged
14.
Clin Exp Dent Res ; 10(3): e911, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38881225

ABSTRACT

OBJECTIVES: Gingiva is one of the supporting tissues around the teeth that can be affected by various neoplastic or nonneoplastic lesions. Previous studies have examined several types of gingival lesions, but the lack of a standardized classification system has hindered meaningful comparisons. Additionally, many studies focused primarily on reactive lesions. Our study aims to contribute to the understanding of gingival lesions by investigating their prevalence across age groups, genders, sites, and by their clinical presentation. This research could lead to improved diagnostic accuracy and treatment strategies. MATERIALS AND METHODS: This retrospective study explores the prevalence of gingival lesions based on biopsies during a 22-year span. The patient's demographic details, including age, gender, and lesion's clinical presentation were systematically collected. These lesions were categorized into six groups. Descriptive statistics, χ2 test of independence, and one-way ANOVA were used for data analysis. RESULTS: Among the 7668 biopsied lesions, 684 (8.9%) lesions were located in the gingiva, with a greater occurrence in women (63.5%). Soft tissue tumors represented the most prevalent group in the gingival lesions (72.1%), and peripheral giant cell granuloma (PGCG) was the most frequent lesion (21.2%), followed by, pyogenic granuloma (19.3%), peripheral ossifying fibroma (17.8%) and focal fibrous hyperplasia (7.6%); all of which predominantly affected women, with mean ages falling in the fourth decade of life. Squamous cell carcinoma was recognized as the most common malignancy. CONCLUSION: In this study, PGCG was found to be the most common lesion in the gingiva in Iranian population. Further analysis using a unanimous categorization is required to confirm these results.


Subject(s)
Gingival Diseases , Humans , Female , Retrospective Studies , Iran/epidemiology , Male , Adult , Prevalence , Gingival Diseases/epidemiology , Gingival Diseases/pathology , Adolescent , Middle Aged , Child , Young Adult , Aged , Child, Preschool , Gingival Neoplasms/epidemiology , Gingival Neoplasms/pathology , Granuloma, Giant Cell/epidemiology , Granuloma, Giant Cell/pathology , Gingiva/pathology , Granuloma, Pyogenic/epidemiology , Granuloma, Pyogenic/pathology , Infant , Biopsy , Fibroma, Ossifying/epidemiology , Fibroma, Ossifying/pathology , Aged, 80 and over
15.
Oral Health Prev Dent ; 11(1): 71-9, 2013.
Article in English | MEDLINE | ID: mdl-23507684

ABSTRACT

PURPOSE: To retrospectively analyse the frequency and distribution of various biopsied lesions of the gingiva among patients attending a dental teaching institution in Karnataka state in India. MATERIALS AND METHODS: Data collected from 153 gingival biopsies referred to the Department of Oral Pathology, Yenepoya Dental College in Mangalore, Karnataka state, India during a 5-year period from 2004-2008 were utilised for the purpose of this study. Lesions were categorised by their type and analysed for age, sex and location. RESULTS: Non-neoplastic lesions accounted for 51% while neoplastic and potentially malignant lesions accounted for 49% of the lesions. The most common non-neoplastic lesion was pyogenic granuloma (42.3%), the most common benign neoplasm was fibroma (34.5%) and the most common malignant lesion was squamous cell carcinoma (82.6%). Among all the lesions, the most common was squamous cell carcinoma (24.8% of all the lesions). CONCLUSIONS: Unlike in previous studies, squamous cell carcinoma was the most common gingival lesion. The proportion of malignant and potentially malignant lesions was also higher among subjects in the present study than in other populations. Hence, public oral health programmes need to be formulated to better tackle the burden of these diseases.


Subject(s)
Gingival Diseases/epidemiology , Gingival Diseases/pathology , Adolescent , Adult , Age Distribution , Aged , Carcinoma, Squamous Cell/epidemiology , Carcinoma, Squamous Cell/pathology , Chi-Square Distribution , Child , Child, Preschool , Female , Fibroma/epidemiology , Fibroma/pathology , Gingival Neoplasms/epidemiology , Gingival Neoplasms/pathology , Granuloma, Pyogenic/epidemiology , Granuloma, Pyogenic/pathology , Humans , India/epidemiology , Infant , Male , Middle Aged , Mouth Mucosa/pathology , Retrospective Studies , Sex Distribution , Young Adult
16.
J Contemp Dent Pract ; 14(2): 174-8, 2013 Mar 01.
Article in English | MEDLINE | ID: mdl-23811641

ABSTRACT

AIM: Oral mucosal lesions are frequently observed in institutionalized elderly patients more than other age groups. The aim of this study was to determine the prevalence of epulis fissuratum and denture stomatitis and their associated causes in dependent elderly complete denture wearers. MATERIALS AND METHODS: This study was conducted in dependent elderly complete denture's wearers living in four randomly selected nursing homes located in Tehran. Associated factors such as gender, age, use of medication, site of nursing home, denture quality and denture-wearing habit were studied. RESULTS: Overall, 674 patients were examined; 201 had complete denture. The prevalence of denture stomatitis was 36%. There was significant relationship among the prevalence of denture stomatitis with gender and denture wearing period (p < 0.05). The prevalence of epulis fissuratum was 16.4%. There was significant relationship among the prevalence of epulis fissuratum with gender, denture quality and denture wearing habit (p < 0.05). CONCLUSION: In this particular dependent age group, the prevalence of oral mucosal lesions is high and the mentioned associated factors should be noticed. CLINICAL SIGNIFICANCE: Dependent elderly complete denture wearers need more support and motivation for reducing the prevalence of these particular denture-associated oral mucosal lesions.


Subject(s)
Denture, Complete/statistics & numerical data , Gingival Diseases/epidemiology , Institutionalization/statistics & numerical data , Stomatitis, Denture/epidemiology , Age Factors , Aged , Antidepressive Agents/therapeutic use , Antihypertensive Agents/therapeutic use , Cross-Sectional Studies , Denture, Complete/standards , Drug Therapy/statistics & numerical data , Female , Humans , Hyperplasia , Iran/epidemiology , Male , Nursing Homes/statistics & numerical data , Prevalence , Residence Characteristics/statistics & numerical data , Sex Factors , Time Factors
17.
J Am Acad Dermatol ; 67(4): 687-93, 2012 Oct.
Article in English | MEDLINE | ID: mdl-22226814

ABSTRACT

BACKGROUND: Patients with facial port-wine stains (PWS) often demonstrate oral manifestations of their disorder; however, the spectrum and prevalence of such findings among a cohort of patients with PWS has not been established. As a result, dermatologists and oral health specialists may be uncertain how to counsel their patients with PWS regarding oral hypervascularity, bony oral changes, and oral hygiene. OBJECTIVES: We sought to identify physical findings and complications involving the teeth, oral cavity, and perioral structures in individuals with facial PWS. METHODS: This was a cross-sectional study of 30 patients with facial PWS. Descriptive data were collected through anonymous paired surveys completed by patients and their dentists, and analyzed (Fisher exact test) for trends based on physical findings and stage of the PWS. RESULTS: The most common orodental manifestations according to patients were enlargement of the lip (53.3%), stained gums (46.7%), abnormal bite (30%), and spontaneous bleeding of the gums (26.7%). Staining of the gingiva correlated significantly with gingival hyperplasia (P = .006), maxillary hyperplasia (P = .014), and widened interdental spaces (P = .002), and in all cases gingival staining predated these findings. Lip hyperplasia was reported more frequently by patients than by their dentists (50% vs 18.2%, P = .008). Orodental manifestations were more common among patients with darker and thicker PWS. Hemorrhage after dental procedures was rare (4.5%). LIMITATIONS: Modest sample size and difficulty recruiting control subjects are limitations. CONCLUSIONS: Facial PWS commonly affect the orodental structures, and intraoral staining may predict future complications.


Subject(s)
Gingival Diseases/epidemiology , Lip Diseases/epidemiology , Malocclusion/epidemiology , Port-Wine Stain/epidemiology , Tongue Diseases/epidemiology , Adolescent , Adult , Child , Child, Preschool , Cohort Studies , Cross-Sectional Studies , Female , Gingival Diseases/pathology , Health Surveys , Humans , Hyperplasia/pathology , Infant , Lip Diseases/pathology , Male , Malocclusion/pathology , Middle Aged , Oral Hygiene , Port-Wine Stain/pathology , Prevalence , Risk Factors , Tongue Diseases/pathology , Young Adult
18.
J Biol Regul Homeost Agents ; 26(3): 553-60, 2012.
Article in English | MEDLINE | ID: mdl-23034275

ABSTRACT

Piercing is the practice of puncturing some parts of the body to apply ornamental objects. The presence of oral and perioral piercings are a risk factor for many acute and chronic complications, such as chipping of the dental enamel, periodontal lesions and infection. The aim of this study is to assess the prevalence of lip and tongue piercing complications in the dental and periodontal tissues in a sample of young adults. Twenty-five adult patients were examined (test group: 11 males and 14 females with an average age of 23.4+/-3.6 years) who had had a minimum of one labial or tongue piercing for at least 1 year and were compared with 25 subjects (control group: 11 males - 44 percent, and 14 females - 56 percent) without any lingual or labial piercing. A questionnaire was compiled for each patient and a clinical examination was performed. The following parameters were examined by the same operator: abnormal toothwear, tooth chipping or cracking, clinical attachment loss (CAL), probing pocket depth (PD) and gingival recession (GR, classified by using Miller s classification). The data were analyzed using X2 or Fisher s exact test for small numbers and non-parametric Mann-Whitney or Kruskal-Wallis tests to examine for differences in continuity; the level of significance was p less than 0.05. According to the results found in the present study the prevalence of abnormal tooth wear and tooth chipping was higher in the subjects with labial or lingual piercing. Moreover, patients with tongue or labial piercing exhibited a higher GR in comparison to control subjects without any oral piercing. No differences were observed between the two groups as regards CAL and PD. A significant association between the duration of piercing and dental defects was found in the group of patients with piercings with greater prevalence of tooth and periodontal defects in the group of 13 subjects who had had the piercings for a period less than or equal to 4 years.


Subject(s)
Body Piercing/adverse effects , Gingival Diseases , Surveys and Questionnaires , Tooth Fractures , Tooth Wear , Adult , Female , Gingival Diseases/epidemiology , Gingival Diseases/etiology , Humans , Male , Time Factors , Tooth Fractures/epidemiology , Tooth Fractures/etiology , Tooth Wear/epidemiology , Tooth Wear/etiology
19.
Pediatr Dermatol ; 29(3): 301-5, 2012.
Article in English | MEDLINE | ID: mdl-21995277

ABSTRACT

We performed a descriptive survey of 1,000 consecutive newborns cared for in the first 3 days of life in the health area of Ferrol (in northwest Spain) to assess the prevalence and most-frequent locations of oral cysts and milia and to study the influence of different maternal and neonatal parameters in the development of these lesions. Prevalence of palatal, gingival, and cutaneous cysts was 53.7%, 13.4%, and 16.6%, respectively. Milia were predominantly located on the cheeks, chin, and forehead. We found a frequent association between palatal and gingival cysts but not between oral cysts and milia. Neonatal factors such as sex, weight at birth, and gestational age can significantly influence the development of palatal and gingival cysts.


Subject(s)
Cysts/epidemiology , Epidermal Cyst/epidemiology , Gingival Diseases/epidemiology , Palate , Female , Humans , Infant, Newborn , Male , Prevalence , Spain/epidemiology
20.
Gerodontology ; 29(2): e930-4, 2012 Jun.
Article in English | MEDLINE | ID: mdl-22136071

ABSTRACT

OBJECTIVE: The aim of this study was to determine the prevalence of oral mucosal lesions in institutionalized elderly people in Mashhad, northeast of Iran. BACKGROUND: This study was conducted to assess the prevalence of oral lesions in the institutionalized elderly. METHODS: In this survey, we studied all of the nursing homes in Mashhad; a total of five encompassing 237 residents. The subjects were examined and lesions recorded in a designed checklist. T-test, chi-square and Fisher's exact tests were used for the analysis. RESULTS: The mean age of the patients was 79.59 ± 8.88. Ninety-eight per cent of cases had at least one oral mucosal lesion. The most common lesions were fissured tongue (66.5%), atrophic glossitis (48.8%), sublingual varicosity (42%) and xerostomia (38%). There was no significant difference in the prevalence of denture-related lesions (DRLs) between men and women (p > 0.05). Xerostomia was more prevalent in 70-79-year-old than in 60-69-year-old subjects. No case of oral malignant lesion was detected. DISCUSSION: These findings revealed a higher prevalence of oral mucosal lesions in Mashhad city compared with other studies conducted in other major cities in Iran and abroad. The results emphasise the necessity of national programmes towards oral health promotion.


Subject(s)
Institutionalization/statistics & numerical data , Mouth Diseases/epidemiology , Age Factors , Aged , Cardiovascular Diseases/epidemiology , Checklist , Dementia/epidemiology , Educational Status , Female , Gingival Diseases/epidemiology , Glossitis/epidemiology , Homes for the Aged/statistics & numerical data , Humans , Hypertension/epidemiology , Iran/epidemiology , Male , Middle Aged , Nursing Homes/statistics & numerical data , Prevalence , Sex Factors , Social Class , Stomatitis, Denture/epidemiology , Tongue/blood supply , Tongue, Fissured/epidemiology , Varicose Veins/epidemiology , Xerostomia/epidemiology
SELECTION OF CITATIONS
SEARCH DETAIL