[Alkaline phosphatase and transketolase activity during immunogenesis in the lymphoid organs of rats with vitamin B1 deficiency caused by oxythiamine]. / Aktivnsot' shchelochnoi fosfatazy i transketolazy v limfoidnykh organakh krys s nedostatochnost'iu vitamina B1, vyzvannoi oksitiaminom, pri immunogeneze.

A study was made of the effect of different doses of hydroxythiamine on activity of alkaline phosphatase and transketolase in rat spleen and thymus during primary and secondary administration of human gamma-globulin. Immunization of rats significantly raised alkaline phosphatase activity in both organs. Administration of a large single dose of hydroxythiamine (400 mg/kg bw) reduced transketolase activity in the thymus and spleen in both immunized and non-immunized animals and did not change alkaline phosphatase activity in these organs.

[Change in the activity of specific and nonspecific immunity mechanisms in vitamin B1 deficiency]. / Izmenenie aktivonsti nekotorykh mekhanizmov spetsificheskogo i nespetsificheskogo immuniteta pri B1-vitaminnoi nedostatochnosti.

The effect of thiamin deficiency on the immune response and activity of some mechanisms of natural immunity was studied in experimental mature rats. Thiamin deficiency was simulated by a single injection of hydroxythiamin (thiamin antagonists). Hydroxythiamin markedly decreased the complement activity, phagocytic activity of peripheral blood leucocytes, serum bactericidal activity as well as antibody production in response to sheep red blood cells. On the contrary, lysozyme activity increased. Vitamin B1 deficiency reduced 14C-leucine incorporation activity in the liver proteins.