Anti-Solvent-Free Preparation for Efficient and Photostable Pure-Iodide Wide-Bandgap Perovskite Solar Cells.

The perovskite/silicon tandem solar cell (TSC) has attracted tremendous attention due to its potential to breakthrough the theoretical efficiency set for single-junction solar cells. However, the perovskite solar cell (PSC) designed as its top component cell suffers from severe photo-induced halide segregation owing to its mixed-halide strategy for achieving desirable wide-bandgap (1.68 eV). Developing pure-iodide wide-bandgap perovskites is a promising route to fabricate photostable perovskite/silicon TSCs. Here, we report efficient and photostable pure-iodide wide-bandgap PSCs made from an anti-solvent-free (ASF) technique. The ASF process is achieved by mixing two precursor solutions, both of which are capable of depositing corresponding perovskite films without involving anti-solvent. The mixed solution finally forms Cs0.3DMA0.2MA0.5PbI3 perovskite film with a bandgap of 1.68 eV. Furthermore, methylammonium chloride additive is applied to enhance the crystallinity and reduce the trap density of perovskite films. As a result, the pure-iodide wide-bandgap PSC delivers efficiency as high as 21.30 % with excellent photostability, the highest for this type of solar cells. The ASF method significantly improves the device reproducibility as compared with devices made from other anti-solvent methods. Our findings provide a novel recipe to prepare efficient and photostable wide-bandgap PSCs.

One-Stone-For-Three-Birds Strategy Using a Fullerene Modifier for Efficient and Stable Inverted Perovskite Solar Cells.

The electron extraction from perovskite/C60 interface plays a crucial role in influencing the photovoltaic performance of inverted perovskite solar cells (PSCs). Here, we develop a one-stone-for-three-birds strategy via employing a novel fullerene derivative bearing triple methyl acrylate groups (denoted as C60-TMA) as a multifunctional interfacial layer to optimize electron extraction at the perovskite/C60 interface. It is found that the C60-TMA not only passivates surface defects of perovskite via coordination interactions between C=O groups and Pb2+ cations but also bridge electron transfer between perovskite and C60. Moreover, it effectively induces the secondary grain growth of the perovskite film through strong bonding effect, and this phenomenon has never been observed in prior art reports on fullerene related studies. The combination of the above three upgrades enables improved perovskite film quality with increased grain size and enhanced crystallinity. With these advantages, C60-TMA treated PSC devices exhibit a much higher power conversion efficiency (PCE) of 24.89% than the control devices (23.66%). Besides, C60-TMA benefits improved thermal stability of PSC devices, retaining over 90% of its initial efficiency after aging at 85 °C for 1200 h, primarily due to the reinforced interfacial interactions and improved perovskite film quality.

Wide-Bandgap Perovskite Solar Cell Using a Fluoride-Assisted Surface Gradient Passivation Strategy.

Wide-band gap (1.68 eV) perovskite solar cells (PSCs) are important components of perovskite/Si tandem devices. However, the efficiency of wide band gap PSCs has been limited by their huge open-circuit voltage (Voc ) deficit due to non-radiative recombination. Deep-level acceptor defects are identified as the major killers of Voc , and they can be effectively improved by passivation with ammonium salts. Theoretical calculation predicts that increasing the distance between F and -NH3 + of fluorinated ammonium can dramatically enhance the electropositivity of -NH3 + terminals, thus providing strong adsorption onto the negatively charged IA and IPb anti-site defects. Characterizations further confirm that surface gradient passivation employing p-FPEAI demonstrates the most efficient passivation effect. Consequently, a record-efficiency of 21.63 % with the smallest Voc deficit of 441 mV is achieved for 1.68 eV-band gap inverted PSCs. Additionally, a flexible PSC and 1 cm2 opaque device also deliver the highest PCEs of 21.02 % and 19.31 %, respectively.

Surface Reconstruction for Efficient NiOx-Based Inverted Perovskite Solar Cells.

Functional agents are verified to efficiently enhance device performance of perovskite solar cells (PSCs) through surface engineering. However, the influence of intrinsic characteristics of molecules on final device performance is overlooked. Here, a surface reconstruction strategy is developed to enhance the efficiency of inverted PSCs by mitigating the adverse effects of lead chelation (LC) molecules. Bathocuproine (BCP) is chosen as the representative of LC molecules for its easy accessibility and outstanding optoelectronic properties. During this strategy, BCP molecules on perovskite surface are first dissolved in solvents and then captured specially by undercoordinated Pb2+ ions, preventing adverse n-type doping by the molecules themselves. In this case, the BCP molecule exhibits outstanding passivation effect on perovskite surface, which leads to an obviously increased open-circuit voltage (VOC). Therefore, a record power conversion efficiency of 25.64% for NiOx-based inverted PSCs is achieved, maintaining over 80% of initial efficiency after exposure to ambient condition for ≈1500 h.

Prominin 2 decreases cisplatin sensitivity in non-small cell lung cancer and is modulated by CTCC binding factor.

BACKGROUND: Non-small cell lung cancer (NSCLC) is the major pathological type of lung cancer and accounts for the majority of lung cancer-related deaths worldwide. We investigated the molecular mechanism of prominin 2 (PROM2) involved in cisplatin resistance in NSCLC. PATIENTS AND METHODS: The GEO database was analyzed to obtain differential genes to target PROM2. Immunohistochemistry and western blotting were used to detect protein expression levels. To examine the role of PROM2 in NSCLC, we overexpressed or knocked down PROM2 by transfection of plasmid or small interfering RNA. In functional experiments, CCK8 was used to detect cell viability. Cell migration and invasion and apoptosis were detected by transwell assay and flow cytometry, respectively. Mechanistically, the regulation of PROM2 by CTCF was detected by ChIP-PCR. In vivo experiments confirmed the role of PROM2 in NSCLC. RESULTS: GEO data analysis revealed that PROM2 was up-regulated in NSCLC, but its role in NSCLC remains unclear. Our clinical samples confirmed that the expression of PROM2 was markedly increased in NSCLC tissue. Functionally, Overexpression of PROM2 promotes cell proliferation, migration and invasion, and cisplatin resistance. CTCF up-regulates PROM2 expression by binding to its promoter region. In vivo experiments confirmed that PROM2 knockdown could inhibit tumor growth and increase the sensitivity of tumor cells to cisplatin. CONCLUSIONS: PROM2 up-regulation in NSCLC can attenuate the sensitivity of NSCLC cells to cisplatin and promote the proliferation, migration and invasion of tumor cells. PROM2 may provide a new target for the treatment of NSCLC.

Recent Advances in Wide-Bandgap Organic-Inorganic Halide Perovskite Solar Cells and Tandem Application.

Perovskite-based tandem solar cells have attracted increasing interest because of its great potential to surpass the Shockley-Queisser limit set for single-junction solar cells. In the tandem architectures, the wide-bandgap (WBG) perovskites act as the front absorber to offer higher open-circuit voltage (VOC) for reduced thermalization losses. Taking advantage of tunable bandgap of the perovskite materials, the WBG perovskites can be easily obtained by substituting halide iodine with bromine, and substituting organic ions FA and MA with Cs. To date, the most concerned issues for the WBG perovskite solar cells (PSCs) are huge VOC deficit and severe photo-induced phase separation. Reducing VOC loss and improving photostability of the WBG PSCs are crucial for further efficiency breakthrough. Recently, scientists have made great efforts to overcome these key issues with tremendous progresses. In this review, we first summarize the recent progress of WBG perovskites from the aspects of compositions, additives, charge transport layers, interfaces and preparation methods. The key factors affecting efficiency and stability are then carefully discussed, which would provide decent guidance to develop highly efficient and stable WBG PSCs for tandem application.

21.15%-Efficiency and Stable γ -CsPbI3 Perovskite Solar Cells Enabled by an Acyloin Ligand.

Cesium lead triiodide (CsPbI3 ) is a promising light-absorbing material for constructing perovskite solar cells (PSCs) owing to its favorable bandgap and thermal tolerance. However, the high density of defects in the CsPbI3 film not only act as recombination centers, but also facilitate ion migration, leading to lower PCE and inferior stability compared with the state-of-the-art organic-inorganic hybrid PSC counterpart. Theoretical analyses suggest that the effective suppression of defects in CsPbI3 film is helpful for improving the device performance. Herein, the stable and efficient γ -CsPbI3 PSCs are demonstrated by developing an acyloin ligand (1,2-di(thiophen-2-yl)ethane-1,2-dione (DED)) as a phase stabilizer and defect passivator. The experiment and calculation results confirm that carbonyl and thienyl in DED can synergistically interact with CsPbI3 by forming a chelate to effectively passivate Pb-related defects and further suppress ion migration. Consequently, DED-treated CsPbI3 PSCs yield a champion PCE of 21.15%, which is one of the highest PCE among all the reported CsPbI3 PSCs to date. In addition, the unencapsulated DED-CsPbI3 PSC can retain 94.9% of itsinitial PCE when stored under ambient conditions for 1000 h and 92.8% of its initial PCE under constant illumination for 250 h.

25.24%-Efficiency FACsPbI3 Perovskite Solar Cells Enabled by Intermolecular Esterification Reaction of DL-Carnitine Hydrochloride.

Judicious tailoring of the interface between the SnO2 electron-transport layer and the perovskite buried surface plays a pivotal role in obtaining highly efficient and stable perovskite solar cells (PSCs). Herein, a DL-carnitine hydrochloride (DL) is incorporated into the perovskite/SnO2 interface to suppress the defect-states density. A DL-dimer is obtained at the interface by an intermolecular esterification reaction. For the SnO2 film, the Cl- in the DL-dimer can passivate oxygen vacancies (VO ) through electrostatic coupling, while the N in the DL-dimer can coordinate with the Sn4+ to passivate Sn-related defects. For the perovskite film, the DL-dimer can passivate FA+ defects via hydrogen bonding and Pb-related defects more efficiently than the DL monomer. Upon DL-dimer modification, the interfacial defects are effectively passivated and the quality of the resultant perovskite film is improved. As a result, the DL-treated device achieves a gratifying open-circuit voltage (VOC ) of 1.20 V and a champion power conversion efficiency (PCE) of 25.24%, which is a record value among all the reported FACsPbI3 PSCs to date. In addition, the unencapsulated devices exhibit a charming stability, sustaining 99.20% and 90.00% of their initial PCEs after aging in air for 1200 h and continuously operating at the maximum power point tracking for 500 h, respectively.

Interface Modification for Efficient and Stable Inverted Inorganic Perovskite Solar Cells.

Due to their excellent thermal stability and ideal bandgap, metal halide inorganic perovskite based solar cells (PSCs) with inverted structure are considered as an excellent choice for perovskite/silicon tandem solar cells. However, the power conversion efficiency (PCE) of inverted inorganic perovskite solar cells (PSCs) still lags far behind that of conventional n-i-p PSCs due to interfacial energy level mismatch and high nonradiative charge recombination. Herein, the performance of inverted PSCs is significantly improved by interfacial engineering of CsPbI3- x Brx films with 2-mercapto-1-methylimidazole (MMI). It is found that the mercapto group can preferably react with the undercoordinated Pb2+ from perovskite by forming Pb-S bonds, which appreciably reduces the surface trap density. Moreover, MMI modification results in a better energy level alignment with the electron-transporting material, promoting carrier transfer and reducing voltage deficit. The above combination results in an open-circuit voltage enhancement by 120 mV, yielding a champion PCE of 20.6% for 0.09 cm2 area and 17.3% for 1 cm2 area. Furthermore, the ambient, operational and heat stabilities of inorganic PSCs with MMI modification are also greatly improved. The work demonstrates a simple but effective approach for fabricating highly efficient and stable inverted inorganic PSCs.

Perovskite-based tandem solar cells.

The power conversion efficiency for single-junction solar cells is limited by the Shockley-Quiesser limit. An effective approach to realize high efficiency is to develop multi-junction cells. These years have witnessed the rapid development of organic-inorganic perovskite solar cells. The excellent optoelectronic properties and tunable bandgaps of perovskite materials make them potential candidates for developing tandem solar cells, by combining with silicon, Cu(In,Ga)Se2 and organic solar cells. In this review, we present the recent progress of perovskite-based tandem solar cells, including perovskite/silicon, perovskite/perovskite, perovskite/Cu(In,Ga)Se2, and perovskite/organic cells. Finally, the challenges and opportunities for perovskite-based tandem solar cells are discussed.

An Electrically Modulated Single-Color/Dual-Color Imaging Photodetector.

An electrically modulated single-/dual-color imaging photodetector with fast response speed is developed based on a small molecule (COi 8DFIC)/perovskite (CH3 NH3 PbBr3 ) hybrid film. Owing to the type-I heterojunction, the device can facilely transform dual-color images to single-color images by applying a small bias voltage. The photodetector exhibits two distinct cut-off wavelengths at ≈544 nm (visible region) and ≈920 nm (near-infrared region), respectively, without any power supply. Its two peak responsivities are 0.16 A W-1 at ≈525 nm and 0.041 A W-1 at ≈860 nm with a fast response speed (≈102 ns). Under 0.6 V bias, the photodetector can operate in a single-color mode with a peak responsivity of 0.09 A W-1 at ≈475 nm, showing a fast response speed (≈102 ns). A physical model based on band energy theory is developed to illustrate the origin of the tunable single-/dual-color photodetection. This work will stimulate new approaches for developing solution-processed multifunctional photodetectors for imaging photodetection in complex circumstances.

Phase Engineering of Perovskite Materials for High-Efficiency Solar Cells: Rapid Conversion of CH3NH3PbI3 to Phase-Pure CH3NH3PbCl3 via Hydrochloric Acid Vapor Annealing Post-Treatment.

Organometal halide CH3NH3PbI3 (MAPbI3) has been commonly used as the light absorber layer of perovskite solar cells (PSCs), and, especially, another halide element chlorine (Cl) has been often incorporated to assist the crystallization of perovskite film. However, in most cases, a predominant MAPbI3 phase with trace of Cl- is obtained ultimately and the role of Cl involvement remains unclear. Herein, we develop a low-cost and facile method, named hydrochloric acid vapor annealing (HAVA) post-treatment, and realize a rapid conversion of MAPbI3 to phase-pure MAPbCl3, demonstrating a new concept of phase engineering of perovskite materials toward efficiency enhancement of PSCs for the first time. The average grain size of perovskite film after HAVA post-treatment increases remarkably through an Ostwald ripening process, leading to a denser and smoother perovskite film with reduced trap states and enhanced crystallinity. More importantly, the generation of MAPbCl3 secondary phase via phase engineering is beneficial for improving the carrier mobility with a more balanced carrier transport rate and enlarging the band gap of perovskite film along with optimized energy level alignment. As a result, under the optimized HAVA post-treatment time (2 min), we achieved a significant enhancement of the power conversion efficiency (PCE) of the MAPbI3-based planar heterojunction-PSC device from 14.02 to 17.40% (the highest PCE reaches 18.45%) with greatly suppressed hysteresis of the current-voltage response.

Imidazole-Functionalized Fullerene as a Vertically Phase-Separated Cathode Interfacial Layer of Inverted Ternary Polymer Solar Cells.

By using a facile one-pot nucleophilic addition reaction, we synthesized a novel imidazole (IMZ)-functionalized fullerene (C60-IMZ), and applied it as a third component of inverted ternary polymer solar cells (PSCs), leading to dramatic efficiency enhancement. According to FT-IR, XPS spectroscopic characterizations, and elemental analysis, the chemical structure of C60-IMZ was determined with the average IMZ addition number estimated to be six. The lowest unoccupied molecular orbital (LUMO) level of C60-IMZ measured by cyclic voltammetry was -3.63 eV, which is up-shifted relative to that of 6,6-phenyl C61-butyric acid methyl ester (PC61BM). Upon doping C60-IMZ as a third component into an active layer blend of poly(3-hexylthiophene) (P3HT) and PC61BM, the power conversion efficiency (PCE) of the inverted ternary PSCs was 3.4% under the optimized doping ratio of 10 wt %, dramatically higher than that of the control device ITO/P3HT:PC61BM/MoO3/Ag based on the binary P3HT:PC61BM blend (1.3%). The incorporation of C60-IMZ results in enhancement of the absorption of P3HT:PC61BM blend film, increase of the electron mobility of the device, and rougher film surface of the P3HT:PC61BM active layer beneficial for interfacial contact with the Ag anode. Furthermore, C60-IMZ doped in P3HT:PC61BM blend may migrate to the surface of ITO cathode via vertical phase separation as revealed by XPS depth analysis, consequently forming a cathode interfacial layer (CIL), which can lower the work function (WF) of ITO cathode. Thus, the interfacial contact between the active layer and ITO cathode is improved, facilitating electron transport from the active layer to ITO cathode. The effectiveness of C60-IMZ as a vertically phase-separated CIL on efficiency enhancement of inverted ternary PSCs is further verified by doping it into another active layer system comprised of a low-bandgap conjugated polymer, poly(thieno[3,4-b]-thiophene/benzodithiophene) (PTB7), blended with [6,6]-phenyl C71-butyric acid methyl ester (PC71BM). Under the optimized C60-IMZ doping ratio of 10 wt %, the PCE of the PTB7:PC71BM-based inverted ternary PSC device reaches 5.3%, which is about 2 times higher than that of the control binary device (2.6%).

Nonconjugated Polymer Poly(vinylpyrrolidone) as an Efficient Interlayer Promoting Electron Transport for Perovskite Solar Cells.

The interfaces between perovskite layer and electrodes play a crucial role on efficient charge transport and extraction in perovskite solar cells (PSCs). Herein, for the first time we applied a low-cost nonconjugated polymer poly(vinylpyrrolidone) (PVP) as a new interlayer between PCBM electron transport layer (ETL) and Ag cathode for high-performance inverted planar heterojunction perovskite solar cells (iPSCs), leading to a dramatic efficiency enhancement. The CH3NH3PbI3-xClx-based iPSC device incorporating the PVP interlayer exhibited a power conversion efficiency (PCE) of 12.55%, which is enhanced by ∼15.9% relative to that of the control device without PVP interlayer (10.83%). The mechanistic investigations based on morphological, optical, and impedance spectroscopic characterizations reveal that incorporation of PVP interlayer promotes electron transport across the CH3NH3PbI3-xClx perovskite/Ag interface via PCBM ETL. Besides, PVP incorporation induces the formation of a dipole layer, which may enhance the built-in potential across the device, conjunctly promoting electron transport from PCBM to Ag cathode and consequently leading to significantly improved fill factor (FF) from 58.98 to 66.13%.

Expression of growth differentiation factor 6 in the human developing fetal spine retreats from vertebral ossifying regions and is restricted to cartilaginous tissues.

During embryogenesis vertebral segmentation is initiated by sclerotomal cell migration and condensation around the notochord, forming anlagen of vertebral bodies and intervertebral discs. The factors that govern the segmentation are not clear. Previous research demonstrated that mutations in growth differentiation factor 6 resulted in congenital vertebral fusion, suggesting this factor plays a role in development of vertebral column. In this study, we detected expression and localization of growth differentiation factor 6 in human fetal spinal column, especially in the period of early ossification of vertebrae and the developing intervertebral discs. The extracellular matrix proteins were also examined. Results showed that high levels of growth differentiation factor 6 were expressed in the nucleus pulposus of intervertebral discs and the hypertrophic chondrocytes adjacent to the ossification centre in vertebral bodies, where strong expression of proteoglycan and collagens was also detected. As fetal age increased, the expression of growth differentiation factor 6 was decreased correspondingly with the progress of ossification in vertebral bodies and restricted to cartilaginous regions. This expression pattern and the genetic link to vertebral fusion suggest that growth differentiation factor 6 may play an important role in suppression of ossification to ensure proper vertebral segmentation during spinal development.

[Double-plating internal fixation through combined approaches for the treatment of medial tibial plateau fractures with fracture-dislocation type].

OBJECTIVE: To investigate the clinical effects of double-plating internal fixation for the treatment of medial tibial plateau fractures with fracture-dislocation type through combined anterior and inverted "L" posteromedial knee approaches. METHODS: From February 2010 to September 2013, 17 patients with medial tibial plateau fractures with fracture-dislocation type were treated by double-plating internal fixation at our department. Anterior knee approach was adopted for medial mass reduction and fixation,while the inverted "L" posteromedial approach was used for posteromedial mass. There were 11 males and 6 females, with an average age of 42 years old (ranged, 21 to 65 years old). The efficacy were investigated by comparing pre- and post-operative radiographic data, and by evaluating clinical symptoms using the HSS score system. RESULTS: All the patients were followed with a mean time of 18 months (ranged, 11 to 25 months). The tibial-plateau varus angle immediately after operation and at the latest follow-up were respectively (87.8 ± 4.2)° and (88.2 ± 4.6)°, and there was no statistical difference (P = 0.458). The posterior slope angle immediately after operation and at the latest follow-up were respectively (10.1 ± 3.7)° and (10.3 ± 4.1)°, and there was no statistical difference (P = 0.512). The knee joint HSS score was 86.7 ± 6.1. No patient had complications such as infection, skin necrosis, internal fixation loosening or loss of fracture reduction. CONCLUSION: Doubl-plating internal fixation through combined approaches is an ideal operation method for medial tibial plateau fractures with fracture-dislocation type, because it can provide clear surgical field, satisfactory reduction, reliable fixation, and chance for early functional exercise.

The effect of SIRT1 gene polymorphisms on ambulatory blood pressure of hypertensive patients in the Kazakh population.

OBJECTIVE: To investigate the effect of silent information regulator 1 (SIRT1) gene polymorphisms on ambulatory blood pressure in hypertensive patients. METHODS: Three hundred forty hypertensive patients were recruited from January 2013 to January 2015. SIRT1 Tag single-nucleotide polymorphisms (SNPs; rs2273773, rs4746720, and rs7896005) were genotyped using a PCR-direct sequencing method, and the association between the SIRT1 gene SNPs and ambulatory blood pressure was analyzed. RESULTS: After adjusting for confounding factors, patients with the rs2273773/CT+CC genotypes had lower 24-h systolic and diastolic blood pressures; there were no associations between rs4746720 and rs7896005 genotypes and blood pressure. CONCLUSION: The SIRT1 gene polymorphism (rs2273773) is significantly associated with ambulatory blood pressure level in Han Chinese patients with hypertension.