1.
J Am Chem Soc
; 135(12): 4580-3, 2013 Mar 27.
Artículo
en Inglés
| MEDLINE
| ID: mdl-23480637
RESUMEN
We report a general method for light-assisted control of interactions of PDZ domain binding motifs with their cognate domains by the incorporation of a photolabile caging group onto the essential C-terminal carboxylate binding determinant of the motif. The strategy was implemented and validated for both simple monovalent and biomimetic divalent ligands, which have recently been established as powerful tools for acute perturbation of native PDZ domain-dependent interactions in live cells.
Asunto(s)
Colorantes Fluorescentes/química , Colorantes Fluorescentes/metabolismo , Dominios PDZ , Péptidos/química , Péptidos/metabolismo , Secuencia de Aminoácidos , Animales , Fluorescencia , Colorantes Fluorescentes/síntesis química , Ligandos , Luz , Modelos Moleculares , Datos de Secuencia Molecular , Péptidos/síntesis química , Fotólisis , Unión Proteica , Mapeo de Interacción de Proteínas , Ratas
2.
Chembiochem
; 11(14): 1979-84, 2010 Sep 24.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20715264