Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Más filtros

Banco de datos
Tipo del documento
Asunto de la revista
País de afiliación
Intervalo de año de publicación
1.
Cell Mol Biol (Noisy-le-grand) ; 67(2): 138-141, 2021 Aug 31.
Artículo en Inglés | MEDLINE | ID: mdl-34817326

RESUMEN

Nitric oxide (NO), as a free radical, is produced by inflamed microglia cells and is one of the destructive factors of the immune system and a factor in myelin degradation. Therefore, inhibition of microglia activity is a chief strategy in reducing neurotoxic damage to the central nervous system. In this study, an herbal Immunomodulatory Drug (IMOD) was used to evaluate the effects of this drug in controlling the amount of nitric oxide. Nitric oxide induction was performed by bacterial lipopolysaccharide (LPS) in rat inflamed microglial cell line, CHME-5. ELISA test was used to measure the produced nitric oxide at 24, 48, and 72 hours. The results showed that the high concentrations of IMOD (1.2, and 4% V/V) had anti-inflammatory effects on microglial cells and were able to reduce the amount of nitric oxide in these cells but the effective dose of IMOD was in the range of 1.2% V/V. Therefore, the safest dose and the best time for the effect of IMOD on inflammatory cell groups are 1.2% V/V and 72h, respectively. Hence, with further studies, IMOD can be considered as an herbal anti-inflammatory drug that is effective in controlling neurodegenerative diseases.


Asunto(s)
Agentes Inmunomoduladores/farmacología , Microglía/efectos de los fármacos , Óxido Nítrico/biosíntesis , Extractos Vegetales/farmacología , Plantas Medicinales/química , Animales , Antiinflamatorios/química , Antiinflamatorios/farmacología , Línea Celular , Relación Dosis-Respuesta a Droga , Agentes Inmunomoduladores/química , Lipopolisacáridos/farmacología , Microglía/citología , Microglía/metabolismo , Extractos Vegetales/química , Ratas , Factores de Tiempo
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA