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Scand J Rheumatol ; 50(4): 295-298, 2021 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-32959708

RESUMEN

Objectives: We investigated whether the positivity of anti-citrullinated peptide antibody (ACPA) is associated with cigarette-smoking status and human T-cell leukaemia virus type 1 (HTLV-1) infection in a general population in Nagasaki, Japan, which is an ageing and HTLV-1-endemic area.Method: Baseline data from community-dwelling people in the Nagasaki Islands Study (NaIS) were included in this cross-sectional analysis. ACPA and HTLV-1 were measured in 3887 subjects without a history of treatment for rheumatoid arthritis. A logistic regression analysis was performed to assess the relationship between ACPA positivity and candidates of correlation with ACPA, i.e. the cigarette-smoking status quantified by Brinkman's index (BI) and HTLV-1 positivity.Results: Fifty-one subjects (1.3%) showed ACPA positivity, and 650 subjects (16.6%) were HTLV-1 carriers. In an age- and gender-adjusted logistic regression analysis, the BI [odds ratio (OR) 1.09, 95% confidence interval (CI)1.02-1.14, p = 0.0031] and a BI value > 500 (OR 3.92, 95% CI 1.72-9.22, p = 0.0014) were each significantly associated with ACPA positivity. HTLV-1 positivity did not show any association with ACPA positivity.Conclusion: A significant effect of cigarette-smoking status on ACPA production was revealed, whereas HTLV-1 positivity was not associated with ACPA production in this general population.


Asunto(s)
Anticuerpos Antiproteína Citrulinada/sangre , Fumar Cigarrillos/inmunología , Infecciones por HTLV-I/inmunología , Adulto , Anciano , Anciano de 80 o más Años , Fumar Cigarrillos/sangre , Estudios Transversales , Femenino , Infecciones por HTLV-I/sangre , Virus Linfotrópico T Tipo 1 Humano , Humanos , Vida Independiente , Japón , Masculino , Persona de Mediana Edad
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