Predictors of the need for necrosectomy in patients with walled-off pancreatic necrosis treated with lumen apposition metal stents.

BACKGROUND AND AIMS: Endoscopic necrosectomy through lumen apposition metal stents (LAMS) is increasingly being used for complicated walled-off pancreatic necrosis (WOPN), but the need for necrosectomy after stent placement is not well understood. The aim of this study was to evaluate clinical, endoscopic, and radiologic predictors of the need for necrosectomy in patients treated with LAMS. METHODS: We retrospectively reviewed patients with WOPN treated with LAMS from 2014 to 2017. Necrosectomy was performed only in patients who had recurrent fever or hemodynamic instability during follow-up. Univariate and multivariate analyses were performed. RESULTS: We included 15 patients, 67% men and median age was 75 (54-76) years. Two (13%) presented adverse events, one immediate and one delayed. In the first case, the stent migrated to the gastric cavity during deployment but was relocated in the same procedure. In the second case, the patient presented bleeding on day 36 due to a pseudoaneurysm that was successfully treated with embolization. Clinical success was 100%, but five patients (33%) required endoscopic necrosectomy (4 mechanical and 1 irrigation) and one (7%) required surgical necrosectomy of distant collections. The percentage of necrosis in the collection detected in a previous CT scan (45 [35-66]% vs 10 [5-17]%) was the only factor to predict the need for necrosectomy in the multivariate analysis (OR 1.18 [1.01-1.39]). CONCLUSION: LAMS is efficient to treat WOPN but more than a third will need necrosectomy. The percentage of necrosis in the collection detected in the CT scan seems to predict the need for necrosectomy.

Influence of antrum size on gastric emptying and weight-loss outcomes after laparoscopic sleeve gastrectomy (preliminary analysis of a randomized trial).

BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has increased in popularity in recent years as a definitive bariatric procedure. Despite its growing popularity worldwide, the surgical technique is not well standardized. There is a lack of evidence on the matter of the antrum size and its relation to gastric emptying and weight-loss outcomes. The aim of the study is to evaluate the influence of antrum size over gastric emptying and weight-loss outcomes. METHODS: Twenty-five patients were prospectively randomized according to the distance between the first firing and the pylorus: AR group (antrum resection-2 cm from the pylorus) and AP group (antrum preservation-5 cm from the pylorus). Gastric emptying (%GE) was evaluated by a gastric emptying scintigraphy before surgery, 2 months and 1 year after LSG. Antrum volume was measured using a MultiSlice CT Scan performed 2 months and 1 year after surgery. The percent of excess weight loss (%EWL) was calculated after 1 year follow-up. RESULTS: At 2 months after LSG the mean %GE was 69.7 ± 18 in the AR group and 72.8 ± 20 in the AP group (p = 0.69). At 1 year it was 66.5 ± 21 and 74.2 ± 16 in the AR and AP groups, respectively (p = 0.30). A significant accelerated gastric emptying was observed at 2 months (p = 0.025) and at 1 year (p = 0.013) in the AP group. Meanwhile in the AR group this increase was not significant (p = 0.12 at 2 months and p = 0.21 at 1 year). Differences regarding the %EWL between groups were no statistically significant (p = 0.74). CONCLUSIONS: After LSG there is a global tendency to an accelerated gastric emptying, although only significant in the antrum preservation group; however, no differences were observed regarding the %EWL between groups after 1 year follow-up.

Predicting the pathological features of the mesorectum before the laparoscopic approach to rectal cancer.

Pelvic anatomy and tumour features play a role in the difficulty of the laparoscopic approach to total mesorectal excision in rectal cancer. The aim of the study was to analyse whether these characteristics also influence the quality of the surgical specimen. We performed a prospective study in consecutive patients with rectal cancer located less than 12 cm from the anal verge who underwent laparoscopic surgery between January 2010 and July 2013. Exclusion criteria were T1 and T4 tumours, abdominoperineal resections, obstructive and perforated tumours, or any major contraindication for laparoscopic surgery. Dependent variables were the circumferential resection margin (CMR) and the quality of the mesorectum. Sixty-four patients underwent laparoscopic sphincter-preserving total mesorectal excision. Resection was complete in 79.1% of specimens and CMR was positive in 9.7%. Univariate analysis showed tumour depth (T status) (P = 0.04) and promontorium-subsacrum angle (P = 0.02) independently predicted CRM (circumferential resection margin) positivity. Tumour depth (P < 0.05) and promontorium-subsacrum axis (P < 0.05) independently predicted mesorectum quality. Multivariate analysis identified the promontorium-subsacrum angle (P = 0.012) as the only independent predictor of CRM. Bony pelvis dimensions influenced the quality of the specimen obtained by laparoscopy. These measurements may be useful to predict which patients will benefit most from laparoscopic surgery and also to select patients in accordance with the learning curve of trainee surgeons.

Long-term outcome and quality of life after laparoscopic treatment of large paraesophageal hernia.

BACKGROUND: Laparoscopy has been widely used for surgical repair of large paraesophageal hernias (PEHs). The technique, however, entails substantial technical difficulties, such as repositioning the stomach in the abdominal cavity, sac excision, closure of the hiatal gap, and fundoplication. Knowledge of the long-term outcome (>10 years) is scarce. The aim of this article was to evaluate the long-term results of this approach, primarily the anatomic hernia recurrence rate and the impact of the repair on quality of life. METHODS: We identified all patients who underwent laparoscopic repair for PEH between November 1997 and March 2007 and who had a minimum follow-up of 48 months. In March 2011, all available patients were scheduled for an interview, and a radiologic examination with barium swallow was performed. During the interview the patients were asked about the existence/persistence of symptoms. An objective score test, the gastrointestinal quality of life index (GIQLI), was also administered. RESULTS: A total of 77 patients were identified: 17 men (22 %) and 60 women (78 %). The mean age at the time of fundoplication was 64 years (range 24-87 years) and at the review time 73 years (range 34-96 years). The amount of stomach contained within the PEH sac was <50 % in 39 patients (50 %), >50 % in 31 (40 %), and 100 % (intrathoracic stomach) in 7 (9.5 %). A 360º PTFe mesh was used to reinforce the repair in six cases and a polyethylene mesh in three. In May 2011, 55 of the 77 patients were available for interview (71 %), and the mean follow-up was 107 months (range 48-160 months). Altogether, 43 patients (66 %) were asymptomatic, and 12 (21 %) reported symptoms that included dysphagia in 7 patients, heartburn in 3, belching in 1, and chest pain in 1. Esophagography in 43 patients (78 %) revealed recurrence in 20 (46 %). All recurrences were small sliding hernias (<3 cm long). In all, 37 patients (67 %) answered the GIQLI questionnaire. The mean GIQLI score was 111 (range 59-137; normal 147). Patients with objective anatomic recurrence had a quality of life index of 110 (range 89-132) versus 122 in the nonrecurrent hernia group (range 77-138, p < 0.01). Mesh was used to buttress the esophageal hiatus in nine patients. One patient died during the follow-up period. Five of the remaining eight patients (62 %) developed dysphagia, a mesh-related symptom. Three patients required reoperation because of mesh-related complications. Esophagography revealed recurrence in four (50 %) of the eight patients. GIQLI scores were similar in patients with recurrence (126, range 134-119) and without it (111, range 133-186) (p > 0.05). CONCLUSIONS: Long-term follow-up (up to 160 months) in our study showed that laparoscopic PEH repair is clinically efficacious but is associated with small anatomic recurrences in ≤50 % of patients. Further studies are needed to identify the anatomic, pathologic, and physiological factors that may impair outcome, allowing the procedure to be tailored to each patient.

Pancreatoduodenal junction: review of anatomy and pathologic conditions.

INTRODUCTION: The pancreatoduodenal junction is a small anatomic area where pathologic processes involving the distal bile duct, duodenum, pancreatic head, ampulla de Vater, and retroperitoneum converge. Differential diagnosis includes a spectrum of entities that ranges from anatomical variants to malignancies. PURPOSE: The aim of this paper was to review the anatomy and different pathologic conditions, whether tumoral, inflammatory, or congenital in origin, in this specific area that involves the pancreatic head, duodenum, duodenal ampulla, distal pancreatobiliary tract junction, and retroperitoneum. METHODS: Computed tomography (CT) and magnetic resonance (MR) help us to identify specific radiologic signs that allow to divide the pancreatic-duodenal junction abnormalities into three cathegories: (1) normal variants and congenital anomalies (pancreas divisum, santorinicele, annular pancreas,duodenal duplication cyst, choledocal cyst,...); (2) acquired non-tumoral: traumatic, iatrogenic, inflammatory (duodenal hematoma, duodenal iatrogenic perforation, groove pancreatitis, gastroduodenal artery pseudoaneurysm,...); (3) tumoral (pancreatic head adenocarcinoma, periampullary tumors, neuroendocrine pancreatic tumors, duodenal adenocarcinoma,...). The images illustrate morphologic aspects of these entities. RESULTS AND CONCLUSIONS: CT and MR are the most appropiate imaging modalities to evaluate pancreatoduodenal junction. Knowing the imaging features is crucial to reach the right diagnosis and treatment of the different entities that involve this anatomic area.

Spontaneous hepatic portal venous gas in a patient with ulcerative colitis. A case report and a review / Gas venoso portal hepático espontáneo en un paciente con colitis ulcerosa. Reporte de un caso y revisión

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NOTES-assisted transvaginal splenectomy: the next step in the minimally invasive approach to the spleen.

HYPOTHESIS: Natural orifice transluminal endoscopic surgery (NOTES) has marked yet another step forward in less-invasive surgical procedures. Access to solid organs located deep in the left hypochondrium can be difficult using this technique but the transvaginal approach with the patient positioned in full lateral decubitus may be an option. MATERIAL AND METHODS: We present the case of a 60-year-old woman with a symptomatic splenic polycystic tumor. The procedure was carried out by a multidisciplinary team using a standard flexible videogastroscope and endoscopic instruments. Transvaginal visualization of the spleen and standard dissection of attachments were feasible, and splenectomy was completed using transvaginal stapling of the splenic hilum. The organ was extracted transvaginally. RESULTS: The postoperative course was uneventful. The patient had minimal postoperative pain and minimal scars, and was discharged on the second postoperative day. CONCLUSIONS: Transvaginal access can be safely used for operative visualization, hilum transection, and spleen removal with conventional instrumentation, reducing parietal wall trauma to a minimum. The clinical, esthetic, and functional advantages require further analysis.

Can we predict immediate outcome after laparoscopic rectal surgery? Multivariate analysis of clinical, anatomic, and pathologic features after 3-dimensional reconstruction of the pelvic anatomy.

OBJECTIVES: The laparoscopic approach for colon resection is widely accepted but its definitive role in rectal tumors is controversial due to the technical difficulties associated with this procedure. Tumor size and volume, and pelvic dimensions may influence intraoperative and/or immediate outcome. This study aimed to evaluate the predictive value of anatomic and pathologic features on immediate outcome after laparoscopic rectal resection. MATERIAL AND METHODS: The study included a prospective series of 60 patients submitted to laparoscopic resection for rectal tumors. A preoperative computed tomography was performed in all patients. Three-dimension reconstruction of the pelvis, rectal tumor, and prostate was computed. Tumor and prostate volume and diameters were calculated, as were main pelvic diameters (subsacrum-retropubic, coccyx pubis, and promontorium coccyx), and lateral diameters, at the tumor level (3D Doctor Software package). Age, sex, body mass index (BMI), tumor height, previous radiotherapy treatment, and type of procedure (anterior resection, low anterior resection, and abdominoperineal resection) were recorded. Immediate outcome (morbidity, mortality, and stay) was also collected. Dependent variables were operative time, intraoperative difficulty, conversion, and postoperative morbidity. Univariate and multivariate analyses were performed (SPSS package). RESULTS: The series included 36 men and 24 women, with a mean age of 72 years (range, 38-87). Surgical procedures were 10 anterior resections, 31 low anterior resections, and 19 abdominoperineal resections. Conversion rate was 9 of 60 (15%), operative time: 172 minutes (range, 90-360), morbidity: 31% and stay: 9 days (range, 6-43). Multivariate analysis showed tumor craniocaudal length was an independent predictive factor for conversion (P < 0.04, odds ratio [OR]: 1.5, confidence interval [CI]95%: 1-2.2). Pubic coccyx axis (P < 0.005) and sex (P < 0.009) showed independent values for operative time, and BMI (P < 0.02, OR: 1.2, CI 95%:1-1.5) was related to postoperative morbidity. When a subanalysis was performed in relation to sex, independent factors differed between males and females, with a predominance of anatomic and tumor measures in men. CONCLUSION: Local anatomy and pathologic features directly affect surgical outcome in the laparoscopic approach to the rectum. Sex, BMI, lower pelvis diameter, and tumor size are independent predictors for conversion, operative time, and morbidity. These data should be taken into account when planning this kind of procedure.

Incarceracion gástrica en hernia periostomal / Gastric incarceration in a peristomal hernia

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Retromammary fluid collection as a late complication of breast implants: magnetic resonance imaging findings.

Imaging examinations, particularly magnetic resonance imaging (MRI), play an important role in the diagnosis of breast implant complications. Two cases of retroprosthetic serous-like fluid collection, an unusual late complication that has not been described previously in the literature, are presented. It is important for radiologists to know the MRI findings of this complication, which suggest the correct diagnosis, avoiding unnecessary additional procedures.

Quiste retroperitoneal gigante / Giant retroperitoneal cyst

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Síndrome de Carney / Carney Syndrome

En 1977, Carney describió un síndrome inusual caracterizado por la aparición, concomitante o sucesiva, de tres tumores diferentes: leiomiosarcoma gástrico, condroma pulmonar y paraganglioma extraadrenal funcionante. La presencia de dos de los tumores es suficiente para establecer el diagnóstico, y es excepcional que los pacientes manifiesten la tríada completa. Sus principales características clínicas son la alta incidencia en pacientes jóvenes, especialmente mujeres, la multicentricidad de los tumores y la escasa sintomatología local tumoral, particularmente del sarcoma gástrico. Presentamos el caso de un síndrome de Carney en un varón de 55 años con un tumor del estroma gastrointestinal y condromas pulmonares múltiples aparecidos de forma sucesiva, en un intervalo de 18 años (AU)

Nutrición parenteral ciclica en pacientes hospitalizados y en domicilio / Parenteral nutrition cyclic in hospitalized patients at home

La disfunsión prolongada del tubo digestivo o su resección amplia necesita del curso de la Nutrición Artificial por vía venosa. La nutrición parenteral cíclica (perfusión durante 12 o 14 horas con heparinización del catéter durante las restantes horas del día) a demostrado tener ventajas y psico-sociales, metabólicas y nutricionales. En nuestro servicio desde 1985 a 1990 fueron ciclizados 16 pacientes pediátricos de 1 m a 14 años y 4 adultos de 19 a 64 años. Se realizaron en total 6.122 días/paciente de nutrición parenteral; media: 306 días. Fueron ciclizados 4.710 días/paciente, media: 235 días, r: 30-690. Para evaluar la repercusión sobre el estado nutricional se analizó el período durante el cual la nutrición pareteral representó 75 por ciento o más de los aportes calórico nitrogenadas. La duración media fue de 156 días, r: 30-720; aporte calórico media: 82 cal/kg/d r: 52-110 en niños...

Síndrome de pseudoobstrucción cronica intestinal y nutrición parenteral / Chronic intestinal pseudobstruction syndrome and parenteral nutrition

Se comunican 5 pacientes con alteraciones en la propulsión intestinal con sintomas recurrentes de obstrucción intestinal, vomitos 5/5, distension abdominal 3/5, constipación 2/5, diarrea 2/5, en ausencia de oclusión mecánica comprobada por laparotomía exploradora. Un paciente presentó alteraciones histopatológicas compatibles con la variedad miopática del sindrome de pseudo obstrucción intestinal cronica idiopatica, en el resto no se encontraron anormalidades. Dos pacientes pertenecian a la misma familia. El tratamiento con cisapride fue ensayado en 2 casos, obteniendo resultado parcial en uno. Se realizó nutricion parenteral a 4 pacientes, 931 días en total de los cuales en 590 días se utilizó la modadlidad ciclica, en el 81 por ciento de los cuales (480 días) se efectuaron en el domicilio del paciente. Fallecieron 4 niñas, la paciente restante permanece en nutrición parenteral domiciliaria.

Sindrome de intestino corto congénito con malrotación y malformaciones extradigestivas / Short bowel syndrome with malrotation malformations extra-digestive

Presentamos un caso de Síndrome de Intestino Corto Congénito con malrotación, membrana duodenal y malformaciones extradigestivas : Situs inversus totalis, síndrome de Claude Bernard Horner congénito y hemivertebras. El paciente presenado recibió nutrición parenteral hasta la edad de 5 meses. Continuó luego hasta los 10 meses de vida con Nutición Enteral Continua Noctura. Otras publicaciones presentan este síndrome con posible pronóstico. La adaptación intestinal permitó un normal crecimiento, ganancia de peso y desarrolo posterior.