Hookworm Folliculitis: Report of Two Cases of Cutaneous Larva Migrans With Histologically Identified Follicular Involvement.

ABSTRACT: Cutaneous larva migrans (CLM) is an ectoparasitic infestation predominantly caused by nematodes, specifically Ancylostoma braziliense and Ancylostoma caninum, found in tropical and subtropical regions. Although follicular involvement by the parasite is a rare manifestation, with approximately 20 cases reported in the English literature, its pathogenesis remains underexplored. The present study reports 2 cases of CLM presenting with follicular involvement in patients with pruritic lesions following travel to subtropical areas. The first of them is a 32-year-old woman who developed an abdominal skin lesion subsequent to a trip to Thailand and the second is a 28-year-old woman who exhibited a knee lesion after a volunteer mission in Senegal. Histologic examination revealed characteristic features of CLM, such as nematode larvae traversing the hair follicle. The hookworm larvae were observed creating tunnels within the external root sheath. In addition, they were interfacing with the vitreous layer, sparing the perifollicular connective tissue sheath and the Henle layer, and approaching the vicinity of the hair bulb. The application of skin ultrasound to guide the biopsy facilitated the visualization and identification of the parasite within the follicle in the latter case. This study not only underscores follicular involvement in CLM but also provides insights into its anatomopathological presentation and spread through the hair follicle.

Poikilodermatous Plaque-like Hemangioma: Case Presentation and Literature Review.

Poikilodermatous plaque-like hemangioma (PPH) is a recently described clinical and pathological entity, with only 18 cases reported in the literature. Although uncommon, this benign condition presents consistent clinical and histological findings. We present a new case of PPH in an 81-year-old male and review the existing literature. The persistence over time and the need to distinguish PPH from more significant lesions underscore the importance of its clinical and pathological recognition.

[Olfactory ensheathing cell tumour: case report and literature review]. / Tumor de las células envolventes del olfatorio: caso clínico y revisión de la literatura.

Olfactory ensheathing cells are glial cells located in the olfactory bulb and nerve. Microscopically, both olfactory ensheathing cells and Schwann cells have similar morphological and immunohistochemical features. However, olfactory ensheathing cells are negative for Leu-7(CD-57), whereas Schwann cells are positive. We present the case of a 49 year-old male with a history of visual impairment and hyposmia. Radiological CT and MRI studies showed a subfrontal cystic extra-axial mass, which eroded the right cribriform plate, with heterogeneous contrast enhancement. Total excision of the tumour was performed by bifrontal craniotomy. Histological examination initially suggested a schwannoma, with immunohistochemical staining being positive for S-100 protein and negative for epithelial membrane antigen (EMA). However, the tumour was negative for Leu-7. Accordingly, the final diagnosis was olfactory ensheathing cell tumour. Herein, we describe the sixth case of intracranial olfactory ensheathing cell tumour and stress the important role of immunohistochemical techniques in obtaining a definitive diagnosis.

Tumor del estroma extragastrointestinal primario hepático gigante / Giant primary extra gastrointestinal stromal tumor of the liver

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Tumor de las células envolventes del olfatorio: caso clínico y revisión de la literatura / Olfactory ensheathing cell tumour: Case report and literature review

Las células envolventes olfatorias son células gliales que se encuentran en el bulbo y el nervio olfatorios. Las células de Schwann y las células envolventes del olfatorio presentan características morfológicas e inmunohistoquímicas similares. Sin embargo, las células de Schwann son positivas en la tinción con Leu-7(CD-57) mientras que las células envolventes lo son negativas. Presentamos el caso de un varón de 49 años con pérdida de agudeza visual e hiposmia. Los estudios de TC y RM craneal muestran una lesión extraaxial subfrontal quística, que erosiona la lámina cribosa derecha y capta contraste heterogéneamente. Con resección completa mediante craneotomía bifrontal, el estudio histológico inicial sugería schwannoma, con inmunorreactividad positiva para S100 y negativa para EMA. Sin embargo, la tinción con Leu-7 negativa y el diagnóstico definitivo fue de tumor de las células envolventes del olfatorio. Describimos el sexto caso de tumor de las células envolventes del olfatorio intracraneal subrayando la importancia de las técnicas inmunohistoquímicas en su diagnóstico (AU)

Olfactory ensheathing cells are glial cells located in the olfactory bulb and nerve. Microscopically, both olfactory ensheathing cells and Schwann cells have similar morphological and immunohistochemical features. However, olfactory ensheathing cells are negative for Leu-7(CD-57), whereas Schwann cells are positive. We present the case of a 49 year-old male with a history of visual impairment and hyposmia. Radiological CT and MRI studies showed a subfrontal cystic extra-axial mass, which eroded the right cribriform plate, with heterogeneous contrast enhancement. Total excision of the tumour was performed by bifrontal craniotomy. Histological examination initially suggested a schwannoma, with immunohistochemical staining being positive for S-100 protein and negative for epithelial membrane antigen (EMA). However, the tumour was negative for Leu-7. Accordingly, the final diagnosis was olfactory ensheathing cell tumour. Herein, we describe the sixth case of intracranial olfactory ensheathing cell tumour and stress the important role of immunohistochemical techniques in obtaining a definitive diagnosis

Carcinoma invasivo mioblastomatoide (histiocitoide). Presentación de 2 casos y revisión de la literatura / Myoblastomatoid invasive carcinoma (histiocytoid). Report of two cases and review of the literature

El carcinoma histiocitoide de mama es una variante rarade cáncer mamario cuya existencia como entidad distinta deotros tipos ha sido muy debatida, siendo un frecuente problemadiagnóstico debido a la similitud histológica con otrostipos de cáncer mamario, así como al escaso número decasos publicados. Es considerado por algunos autores comouna variante de carcinoma lobulillar infiltrante y suele confundirsefácilmente con condiciones benignas, u otros tumoresmamarios compuestos por células de citoplasma eosinofílicogranular o espumoso y núcleo excéntrico. Con objetode estudiar su incidencia en nuestro medio se han revisado925 carcinomas de mama existentes en nuestro hospital desde1996, encontrándose sólo 7 casos diagnosticados comocarcinoma histiocitoide, 5 de los cuales se han reubicadocomo carcinomas lobulillares pleomórficos con cambiosapocrinos, quedando solo 2 casos que cumplan todos los criterioshistológicos, y citológicos del carcinoma histiocitoide (AU)

Histiocytoid carcinoma of the breast is a rare variant ofbreast cancer, discussed as different subtype from other breastlesions, being a frequent diagnostic problem due to itshystologic similarity with other types of breast cancer, andbecause of the few number of cases in literature. Histiocytoidcarcinoma is considered by some authors as a subtypeof lobular infiltrating carcinoma, easily confused withbenign conditions or other mammary lesions composed ofcells with a pink granular to foamy cytoplasm and eccentricnucleus. We have reviewed 925 cases from our hospital filessince 1996, in order to study the incidence in our area, finding7 cases diagnosed as histiocytoid carcinoma, 5 of themhave been re-classified as pleomorphic lobular carcinomawith apocrine changes, and only two cases were classifiedas histiocytoid carcinoma upon histological, cytological andimmunochemical criteria (AU)

Calcificación arterial idiopática de la infancia en reciénnacido pretérmino con hidrops fetal y síndrome de Down: estudio clínico-patológico / Idiopathic arterial calcification of infancy in a preterm newborn with hydrops fetalis and Down’s syndrome: a clinicopathologic study

Introducción: La calcificación arterial idiopática de lainfancia (CAII) es una entidad congénita extremadamenterara de curso evolutivo casi invariablemente fatal. Caso clínico:Presentamos un caso de estudio de autopsia clínica enrecién nacido varón, pretérmino, de cuatro días de vida conun cuadro de hidrops fetal asociado simultáneamente a unsíndrome de Down y a una calcificación arterial oclusivageneralizada y difusa, con desarrollo secundario de cardiomiopatíahipertrófica e isquemia miocárdica con fallo cardíacocongestivo refractario, necrosis isquémica transmuralyeyunal con perforación y atrofia renal izquierda. Discusión:Se realiza correlación clínico-patológica y se describenlos hallazgos más relevantes del estudio de necropsia (AU)

Introduction: The idiopathic arterial calcification ofthe infancy is a congenital entity extremely rare whose evolutivecourse is invariably fatal. Case report: We present astudy case of a clinical autopsy in a male preterm newbornof 4 days of life with hydrops fetalis simultaneously associatedwith Down’s syndrome and generalised diffuse occlusivearterial calcification with secondary development ofhypertrophic cardiomyopathy and myocardial ischaemiawith refractory congestive cardicac failure, transmural jejunalischaemic necrosis with perforation and left renal atrophy.Discussion: Clinical-pathological correlation is performedand the most relevant findings of the necropsy are described (AU)