Detalhe da pesquisa
1.
Design, synthesis, and biological evaluation of novel benzimidazole derivatives as sphingosine kinase 1 inhibitor.
Arch Pharm (Weinheim)
; 354(9): e2100080, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-34128259
2.
New thiopyrimidine-benzenesulfonamide conjugates as selective carbonic anhydrase II inhibitors: synthesis, in vitro biological evaluation, and molecular docking studies.
Bioorg Med Chem
; 28(5): 115329, 2020 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32007388
3.
Overcoming Obstacles to Clozapine Treatment: A Case of Clozapine Rechallenge in ECT-Resistant Schizophrenia With Catatonic Features.
J Clin Psychopharmacol
; 44(2): 182-185, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38315142
4.
Recurring ST-Elevation Myocardial Infarction With No-Reflow Caused by Hypercoagulable State: A Behcet Disease Case Report.
J Clin Med Res
; 16(5): 264-271, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38855780
5.
Sleep interventions for adults admitted to psychiatric inpatient settings: A systematic scoping review.
Sleep Med Rev
; 76: 101950, 2024 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38788520
6.
Potent Dual Inhibitors of Steroid Sulfatase and 17ß-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for In Vivo Proof-of-Principle Studies in an Endometriosis Mouse Model.
J Med Chem
; 66(13): 8975-8992, 2023 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37369108
7.
Preliminary Evaluation of a Web-Based International Journal Club for Ketamine in Psychiatric Disorders: Cross-Sectional Survey Study.
JMIR Med Educ
; 9: e46158, 2023 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37910164
8.
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle.
Adv Sci (Weinh)
; 10(5): e2204443, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36596691
9.
Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections.
ACS Cent Sci
; 9(12): 2205-2215, 2023 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38161367
10.
Dual Targeting of Steroid Sulfatase and 17ß-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis.
J Med Chem
; 65(17): 11726-11744, 2022 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35993890
11.
Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases.
J Med Chem
; 65(19): 12933-12955, 2022 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36154055
12.
Divergent synthesis and biological evaluation of 2-(trifluoromethyl)pyridines as virulence-attenuating inverse agonists targeting PqsR.
Eur J Med Chem
; 226: 113797, 2021 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34520957
13.
17ß-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer.
ACS Med Chem Lett
; 12(12): 1920-1924, 2021 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34917255
14.
A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms.
Adv Sci (Weinh)
; 8(12): e2004369, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34165899
15.
Inhibitors of 17ß-hydroxysteroid dehydrogenase type 1, 2 and 14: Structures, biological activities and future challenges.
Mol Cell Endocrinol
; 489: 66-81, 2019 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30336189
16.
Effects of 17ß-HSD2 inhibition in bones on osteoporosis based on an animal rat model.
J Steroid Biochem Mol Biol
; 192: 105405, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31185280
17.
Development of potential preclinical candidates with promising in vitro ADME profile for the inhibition of type 1 and type 2 17ß-Hydroxysteroid dehydrogenases: Design, synthesis, and biological evaluation.
Eur J Med Chem
; 178: 93-107, 2019 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31176098
18.
Design, Synthesis, and Biological Characterization of Orally Active 17ß-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis.
J Med Chem
; 62(15): 7289-7301, 2019 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31343176
19.
Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17ß-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing.
J Med Chem
; 62(3): 1362-1372, 2019 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30645111
20.
Highly Potent 17ß-HSD2 Inhibitors with a Promising Pharmacokinetic Profile for Targeted Osteoporosis Therapy.
J Med Chem
; 61(23): 10724-10738, 2018 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30480443