Detalhe da pesquisa
1.
Impact of Heterotropic Allosteric Modulation on the Time-Dependent Inhibition of Cytochrome P450 3A4.
Drug Metab Dispos
; 51(10): 1372-1380, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37524542
2.
Disposition and metabolism of LY2603618, a Chk-1 inhibitor following intravenous administration in patients with advanced and/or metastatic solid tumors.
Xenobiotica
; 44(9): 827-41, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24666335
3.
Pharmacokinetics, metabolism, and excretion of the glycogen synthase kinase-3 inhibitor LY2090314 in rats, dogs, and humans: a case study in rapid clearance by extensive metabolism with low circulating metabolite exposure.
Drug Metab Dispos
; 41(4): 714-26, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23305709
4.
Identification and Mitigation of Reactive Metabolites of 2-Aminoimidazole-Containing Microsomal Prostaglandin E Synthase-1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury.
J Med Chem
; 61(5): 2041-2051, 2018 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29425457
5.
Characterization of dark liver pigment observed in rats after subchronic dosing of the beta3-adrenergic receptor agonist LY368842.
Chem Res Toxicol
; 16(7): 912-9, 2003 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12870894
6.
Metabolism and disposition of the antihypertensive agent moxonidine in humans.
Drug Metab Dispos
; 31(3): 334-42, 2003 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-12584161