Detalhe da pesquisa
1.
Glycan Modulation of Insulin-like Growth Factor-1 Receptor.
Angew Chem Int Ed Engl
; 61(49): e202211320, 2022 12 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36205924
2.
Studies on fragment-based design of allosteric inhibitors of human factor XIa.
Bioorg Med Chem
; 28(23): 115762, 2020 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32992249
3.
Molecular principles for heparin oligosaccharide-based inhibition of neutrophil elastase in cystic fibrosis.
J Biol Chem
; 293(32): 12480-12490, 2018 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29903912
4.
Recent advances in the discovery and development of factor XI/XIa inhibitors.
Med Res Rev
; 38(6): 1974-2023, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29727017
5.
A small group of sulfated benzofurans induces steady-state submaximal inhibition of thrombin.
Bioorg Med Chem Lett
; 28(6): 1101-1105, 2018 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29459207
6.
2-O, 3-O Desulfated Heparin Blocks High Mobility Group Box 1 Release by Inhibition of p300 Acetyltransferase Activity.
Am J Respir Cell Mol Biol
; 56(1): 90-98, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27585400
7.
New Triazole-Based Potent Inhibitors of Human Factor XIIa as Anticoagulants.
ACS Omega
; 9(9): 10694-10708, 2024 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38463342
8.
Triazol-1-yl Benzamides Promote Anticoagulant Activity via Inhibition of Factor XIIa.
Cardiovasc Hematol Agents Med Chem
; 21(2): 108-119, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36321236
9.
Investigation of the anticoagulant activity of cyclic sulfated glycosaminoglycan mimetics.
Carbohydr Res
; 529: 108831, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37209666
10.
Sulphated penta-galloyl glucopyranoside (SPGG) is glycosaminoglycan mimetic allosteric inhibitor of cathepsin G.
RPS Pharm Pharmacol Rep
; 2(1): rqad001, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-36844783
11.
Designing Smaller, Synthetic, Functional Mimetics of Sulfated Glycosaminoglycans as Allosteric Modulators of Coagulation Factors.
J Med Chem
; 66(7): 4503-4531, 2023 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37001055
12.
Homogeneous, Synthetic, Non-Saccharide Glycosaminoglycan Mimetics as Potent Inhibitors of Human Cathepsin G.
Biomolecules
; 13(5)2023 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37238630
13.
Designing Synthetic, Sulfated Glycosaminoglycan Mimetics That Are Orally Bioavailable and Exhibiting In Vivo Anticancer Activity.
J Med Chem
; 66(2): 1321-1338, 2023 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36634271
14.
Dual Targeting of the PDZ1 and PDZ2 Domains of MDA-9/Syntenin Inhibits Melanoma Metastasis.
Mol Cancer Ther
; 22(10): 1115-1127, 2023 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37721536
15.
Factor IX(a) inhibitors: an updated patent review (2003-present).
Expert Opin Ther Pat
; 32(4): 381-400, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-34991418
16.
Lignosulfonic Acid Sodium Is a Noncompetitive Inhibitor of Human Factor XIa.
Pharmaceuticals (Basel)
; 14(9)2021 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-34577586
17.
Sulfated Non-Saccharide Glycosaminoglycan Mimetics as Novel Drug Discovery Platform for Various Pathologies.
Curr Med Chem
; 27(21): 3412-3447, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-30457046
18.
On the Process of Discovering Leads That Target the Heparin-Binding Site of Neutrophil Elastase in the Sputum of Cystic Fibrosis Patients.
J Med Chem
; 62(11): 5501-5511, 2019 06 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31074986
19.
A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding.
J Thromb Haemost
; 17(12): 2110-2122, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31397071
20.
Inhibition of Herpes Simplex Virus-1 Entry into Human Cells by Nonsaccharide Glycosaminoglycan Mimetics.
ACS Med Chem Lett
; 9(8): 797-802, 2018 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30128070