Detalhe da pesquisa
1.
Enabling structure-based drug discovery utilizing predicted models.
Cell
; 187(3): 521-525, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38306979
2.
From computer-aided drug discovery to computer-driven drug discovery.
Drug Discov Today Technol
; 39: 111-117, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34906321
3.
Dose-dependent effects of siRNA-mediated inhibition of SCAP on PCSK9, LDLR, and plasma lipids in mouse and rhesus monkey.
J Lipid Res
; 57(12): 2150-2162, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27707816
4.
Evaluation of CETP activity in vivo under non-steady-state conditions: influence of anacetrapib on HDL-TG flux.
J Lipid Res
; 57(3): 398-409, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26658238
5.
Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans.
J Lipid Res
; 55(8): 1693-701, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24891332
6.
In vivo isotopically labeled atherosclerotic aorta plaques in ApoE KO mice and molecular profiling by matrix-assisted laser desorption/ionization mass spectrometric imaging.
Rapid Commun Mass Spectrom
; 28(22): 2471-9, 2014 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-25303476
7.
Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activity.
iScience
; 27(5): 109693, 2024 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38689642
8.
In vivo effects of anacetrapib on preß HDL: improvement in HDL remodeling without effects on cholesterol absorption.
J Lipid Res
; 54(10): 2858-65, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23898048
9.
Preclinical target validation for non-addictive therapeutics development for pain.
Expert Opin Ther Targets
; 26(9): 811-822, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36424892
10.
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Cell Chem Biol
; 27(1): 32-40.e3, 2020 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31653597
11.
DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates.
Cell Metab
; 27(6): 1236-1248.e6, 2018 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29706567
12.
From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.
Cell Chem Biol
; 28(2): 243, 2021 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33607006
13.
Rhesus monkey model for concurrent analyses of in vivo selectivity, pharmacokinetics and pharmacodynamics of aldosterone synthase inhibitors.
J Pharmacol Toxicol Methods
; 71: 137-46, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25304940
14.
Six novel gonadotropin-releasing hormones are encoded as triplets on each of two genes in the protochordate, Ciona intestinalis.
Endocrinology
; 144(5): 1907-19, 2003 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-12697698
15.
Effects of anacetrapib on plasma lipids, apolipoproteins and PCSK9 in healthy, lean rhesus macaques.
Eur J Pharmacol
; 740: 410-6, 2014 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-24769414
16.
Utilizing HaloTag Technology to Track the Fate of PCSK9 from Intracellular vs. Extracellular Sources.
Curr Chem Genomics
; 6: 38-47, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23115612
17.
Proteomic study of plasma proteins in pregnant women with asthma.
Respirology
; 11(1): 41-8, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16423200
18.
The effect of maternal asthma on placental and cord blood protein profiles.
J Soc Gynecol Investig
; 12(5): 349-55, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15979547
19.
DPP10 modulates Kv4-mediated A-type potassium channels.
J Biol Chem
; 280(19): 18853-61, 2005 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-15671030
20.
Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases.
Biochem J
; 373(Pt 1): 179-89, 2003 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12662155