Carbonic anhydrase III and collagen markers in serum following cross-country skiing.

Protein leakage from type I skeletal muscle cells and collagen synthesizing cells were studied during a 24-h cross-country skiing relay in eight men using serum carbonic anhydrase III (S-CA III) and serum galactosylhydroxylysyl glucosyltransferase (S-GGT) as the respective specific marker proteins. Serum aminoterminal propeptide of type III procollagen (S-Pro(III)-N-P) was used as an indicator of type III collagen synthesis and serum creatine kinase (S-CK) as a nonspecific muscular marker. S-CK, S-CA III, and S-GGT were increased immediately following the skiing relay by 870%, 640%, and 40%, respectively. No significant change was observed in the concentration of S-Pro(III)-N-P following the exercise. A high positive correlation (rs = 0.92, P less than 0.01) was found between the increase in S-CA III and S-CK, whereas no correlation was observed between these muscular markers and S-GGT. The results suggest leakage from type I skeletal muscle cells and collagen synthesizing cells as a consequence of prolonged cross-country skiing, but there seems to exist no dependence between acute responses in muscular and connective tissue cells to exercise.

[Urinary infection caused by non typhi Salmonella]. / Infección urinaria por Salmonella no typhi.

BACKGROUND: The aim of this study was to know the frequency and the clinical characteristics of urinary infection by non typhi Salmonella in our area in Spain. PATIENTS AND METHODS: The clinical histories of patients with urinary infection by non typhi Salmonella diagnosed in the Hospital General del Guadalajara from January 1990 to July 1999 were reviewed. RESULTS: During the period studied nine patients with urinary infection by non typhi Salmonella were diagnosed, representing 0.056% of the urinary infection diagnosed in our hospital over the same period. All the patients presented underlying disease and five were undergoing immunosuppressor treatment. Four patients presented urological disease. The most frequent serogroup was Salmonella enteritidis (7 cases). All the episodes were symptomatic. The same microorganism was isolated in stools in four patients. The evolution was favorable in five of the nine cases. Recurrence was observed in two patients and secondary bacteremia in one. Six patients required antibiotic treatment over two or more weeks. The mean length of treatment was of 2.5 weeks. CONCLUSIONS: Urinary infection by non typhi Salmonella is predominantly observed in patients undergoing immunosuppression or with urological disease. Prolonged antibiotic treatment is recommended due to its bad evolution.