Detalhe da pesquisa
1.
A kinase-cGAS cascade to synthesize a therapeutic STING activator.
Nature
; 603(7901): 439-444, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35296845
2.
Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity.
Bioorg Med Chem
; 66: 116820, 2022 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35594650
3.
Discovery of a new series of PI3K-δ inhibitors from Virtual Screening.
Bioorg Med Chem Lett
; 42: 128046, 2021 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33865969
4.
Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow.
Bioorg Med Chem Lett
; 29(18): 2575-2580, 2019 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31416665
5.
Analyzing the Potential Root Causes of Variability of Pharmacokinetics in Preclinical Species.
Mol Pharm
; 14(5): 1634-1645, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28329443
6.
MARK inhibitors: Declaring a No-Go decision on a chemical series based on extensive DMPK experimentation.
Bioorg Med Chem Lett
; 27(1): 109-113, 2017 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27894874
7.
Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors.
Bioorg Med Chem Lett
; 27(1): 114-120, 2017 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27816515
8.
Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation.
Bioorg Med Chem Lett
; 27(12): 2721-2726, 2017 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28501511
9.
Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties.
Bioorg Med Chem Lett
; 26(17): 4362-6, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27491711
10.
Corrigendum to "Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow" [Bioorg. Med. Chem. Lett. 29 (2019) 2575-2580].
Bioorg Med Chem Lett
; 30(16): 127363, 2020 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32591133
11.
Identification of N-(1H-pyrazol-4-yl)carboxamide inhibitors of interleukin-1 receptor associated kinase 4: Bicyclic core modifications.
Bioorg Med Chem Lett
; 25(22): 5384-8, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26403930
12.
Thiophene carboxamide inhibitors of JAK2 as potential treatments for myleoproliferative neoplasms.
Bioorg Med Chem Lett
; 24(8): 1968-73, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24666646
13.
The discovery of reverse tricyclic pyridone JAK2 inhibitors. Part 2: lead optimization.
Bioorg Med Chem Lett
; 24(6): 1466-71, 2014 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24582987
14.
Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections.
ACS Med Chem Lett
; 15(1): 123-131, 2024 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38229758
15.
Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease.
ACS Med Chem Lett
; 14(2): 146-155, 2023 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36793422
16.
Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.
J Med Chem
; 65(7): 5675-5689, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35332774
17.
Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance.
J Virol
; 84(10): 5368-78, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20237088
18.
Discovery and characterization of novel peptide inhibitors of the NRF2/MAFG/DNA ternary complex for the treatment of cancer.
Eur J Med Chem
; 224: 113686, 2021 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34303079
19.
Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators.
J Med Chem
; 64(8): 5137-5156, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33797901
20.
Discovery of MK-4688: an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction.
J Med Chem
; 64(21): 16213-16241, 2021 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34714078