Detalhe da pesquisa
1.
Predicting Optimal Antimalarial Drug Combinations from a Standardized Plasmodium falciparum Humanized Mouse Model.
Antimicrob Agents Chemother
; 67(6): e0157422, 2023 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37133382
2.
Optimized Pyridazinone Nutrient Channel Inhibitors Are Potent and Specific Antimalarial Leads.
Mol Pharmacol
; 102(3): 172-182, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35798366
3.
A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 522(7556): 315-20, 2015 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26085270
4.
Enzyme Therapy: Current Challenges and Future Perspectives.
Int J Mol Sci
; 22(17)2021 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34502086
5.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941635
6.
Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.
Bioorg Med Chem
; 26(11): 2996-3005, 2018 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29779669
7.
Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.
Nature
; 537(7618): 122, 2016 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27281209
8.
The multistate tuberculosis pharmacometric model: a semi-mechanistic pharmacokinetic-pharmacodynamic model for studying drug effects in an acute tuberculosis mouse model.
J Pharmacokinet Pharmacodyn
; 44(2): 133-141, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28205025
9.
(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.
Proc Natl Acad Sci U S A
; 111(50): E5455-62, 2014 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25453091
10.
Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.
PLoS Med
; 13(10): e1002138, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27701420
11.
Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development.
Antimicrob Agents Chemother
; 60(6): 3669-75, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27044554
12.
Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase.
Antimicrob Agents Chemother
; 60(10): 6271-80, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27503647
13.
Chemical genetics of Plasmodium falciparum.
Nature
; 465(7296): 311-5, 2010 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-20485428
14.
Pharmacokinetic-pharmacodynamic and dose-response relationships of antituberculosis drugs: recommendations and standards for industry and academia.
J Infect Dis
; 211 Suppl 3: S96-S106, 2015 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26009618
15.
Combinations of ß-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection.
Antimicrob Agents Chemother
; 59(8): 4997-9, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25987618
16.
Mycobacterium tuberculosis gyrase inhibitors as a new class of antitubercular drugs.
Antimicrob Agents Chemother
; 59(4): 1868-75, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25583730
17.
Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans.
Antimicrob Agents Chemother
; 59(2): 950-9, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25421480
18.
Identifying rapidly parasiticidal anti-malarial drugs using a simple and reliable in vitro parasite viability fast assay.
Malar J
; 14: 441, 2015 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-26542470
19.
Repositioning: the fast track to new anti-malarial medicines?
Malar J
; 13: 143, 2014 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-24731288
20.
Animal models of efficacy to accelerate drug discovery in malaria.
Parasitology
; 141(1): 93-103, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23789594