RESUMO
Electrically generated silver ions have been shown previously to be a potent antibacterial agent with an exceptionally broad spectrum as indicated by in vitro testing. The present study reports on clinical experience using electrically generated silver ions as adjunctive treatment in the management of chronic osteomyelitis. Fourteen patients had fifteen treatment attempts: thirteen for chronic osteomyelitis of the tibia, one for acute and chronic pyarthrosis and osteomyelitis of the knee, and one for a chronically draining sinus after total hip replacement. Wound débridement, silver ion iontophoresis, and subsequent wound care (usually provided by the patient) resulted in control of the infection in twelve of the fifteen treatment attempts and in healing of the non-union after follow-up ranging from three to thirty-six months. The other three attempts led to two partial and one complete failure.
Assuntos
Anti-Infecciosos Locais/uso terapêutico , Fraturas Ósseas/complicações , Osteomielite/tratamento farmacológico , Prata/uso terapêutico , Adulto , Anti-Infecciosos Locais/administração & dosagem , Desbridamento , Avaliação de Medicamentos , Eletrodos , Feminino , Seguimentos , Fraturas Ósseas/microbiologia , Humanos , Íons , Iontoforese , Masculino , Pessoa de Meia-Idade , Nylons , Osteomielite/microbiologia , Osteomielite/cirurgia , Prata/administração & dosagem , CicatrizaçãoRESUMO
The AC impedance of a length of the H meridian not containing any acupuncture points was studied by means of Laplace plane analysis of the time domain response to an input voltage pulse. The ensuing frequency domain data were compared to the results of an identical analysis for two anatomically similar controls on either side of the meridian. The resistance of the meridian was significantly lower than either control.
Assuntos
Terapia por Acupuntura , Fenômenos Fisiológicos da Pele , Estimulação Elétrica , EletrofisiologiaRESUMO
Loss of body calcium during spaceflight is a potential problem in long voyages. This loss does not appear to be caused by a deficiency in diet or exercise. The idea is advanced that the altered electromagnetic environment experienced in space may be at least partially responsible. We show that the electric field induced inside astronauts because of their motion in the geomagnetic field is greater than that which has produced a wide variety of biological effects in earth-bound experiments.
Assuntos
Fenômenos Eletromagnéticos , Osteoporose/etiologia , Voo Espacial , Cálcio/metabolismo , Humanos , Osteoporose/metabolismoAssuntos
Carcinoma de Ehrlich/genética , Aberrações Cromossômicas , Cromossomos/efeitos da radiação , Eletricidade , Glaucoma/etiologia , Lesões Experimentais por Radiação , Animais , Eletroforese das Proteínas Sanguíneas , Proteínas Sanguíneas/efeitos da radiação , Peso Corporal , Olho/efeitos da radiação , Feminino , Masculino , Camundongos , Camundongos Endogâmicos ICR , Ratos , Uveíte/etiologiaAssuntos
Osso e Ossos/análise , Água , Absorção , Osso e Ossos/metabolismo , Eletroquímica , Humanos , UmidadeAssuntos
Células da Medula Óssea , Medula Óssea/metabolismo , Platina/farmacologia , Prata/farmacologia , Aço Inoxidável/farmacologia , Animais , Medula Óssea/efeitos dos fármacos , Células Cultivadas , Eosinófilos/efeitos dos fármacos , Eosinófilos/metabolismo , Feminino , Granulócitos/efeitos dos fármacos , Granulócitos/metabolismo , Linfócitos/efeitos dos fármacos , Linfócitos/metabolismo , Camundongos , Camundongos Endogâmicos ICR , Neutrófilos/efeitos dos fármacos , Neutrófilos/metabolismo , Fatores de TempoAssuntos
Estimulação Elétrica , Osteogênese , Animais , Eletrodos Implantados , Técnicas In Vitro , Oxigênio , RatosRESUMO
The present technique of electrical osteogenesis represents the rediscovery of a method in clinical use over 100 years ago. That technique while reported to have excellent clinical results, was empirically applied and was totally discredited as having no scientific basis. Modern techniques report similarly useful clinical results, but similarly lack an accepted scientific basis. The techniques in present use differ so greatly among themselves that a common mechanism of action seems highly unlikely. Yet all report excellent clinical results. Serious questions are raised concerning the validity of the claims, the mechanism of action and the possibility of long-term undesirable side effects. These questions are not insoluble and the newer physical science disciplines seem well suited to reveal the mechanism of action. Appropriate research projects must be mounted and answers to these questions obtained before the technique is made available for wide application. The importance of this procedure far transcends orthopedic surgery and bone growth stimulation and if properly pursued, it may lead to revolutionary changes, not only in basic biology, but in the practice of clinical medicine in general.
Assuntos
Terapia por Estimulação Elétrica/métodos , Fraturas Ósseas/terapia , Osteogênese , Anfíbios , Animais , Desenvolvimento Ósseo , Osso e Ossos/inervação , Estimulação Elétrica , Terapia por Estimulação Elétrica/efeitos adversos , Eletrofisiologia , Fraturas Ósseas/fisiopatologia , Humanos , Mamíferos , Coelhos , Risco , UrodelosRESUMO
A study of the use of free silver ions as an antibacterial and antifungal agent administered to infected local wounds has been conducted over the past two decades. A variety of iontophoretic techniques has been employed utilizing either pure silver wires or several types of silvered nylon fabrics as anodes in a direct current electrical circuit. A new type of silver nylon has recently been evaluated for the same use without iontophoretic current. In vitro studies of both techniques have demonstrated an effective, broad spectrum antibiotic effect including most silver-resistant strains. Over 100 cases of recalcitrant osteomyelitis have been treated with an overall success rate of approximately 65% and no evidence of argyria.