Detalhe da pesquisa
1.
Impact of Heterotropic Allosteric Modulation on the Time-Dependent Inhibition of Cytochrome P450 3A4.
Drug Metab Dispos
; 51(10): 1372-1380, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37524542
2.
Hepatic Organic Anion Transporting Polypeptide-Mediated Clearance in the Beagle Dog: Assessing In Vitro-In Vivo Relationships and Applying Cross-Species Empirical Scaling Factors to Improve Prediction of Human Clearance.
Drug Metab Dispos
; 47(3): 215-226, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30593544
3.
The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2C9 and CYP3A4 Substrates.
Drug Metab Dispos
; 45(9): 1008-1018, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28679672
4.
The Impact of the Hepatocyte-to-Plasma pH Gradient on the Prediction of Hepatic Clearance and Drug-Drug Interactions for CYP2D6 Substrates.
Drug Metab Dispos
; 44(11): 1819-1827, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27590024
5.
Difference in the Pharmacokinetics and Hepatic Metabolism of Antidiabetic Drugs in Zucker Diabetic Fatty and Sprague-Dawley Rats.
Drug Metab Dispos
; 44(8): 1184-92, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27217490
6.
In vitro characterization of the bioconversion of pomaglumetad methionil, a novel metabotropic glutamate 2/3 receptor agonist peptide prodrug.
Drug Metab Dispos
; 43(5): 756-61, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25755052
7.
Ablation of both organic cation transporter (OCT)1 and OCT2 alters metformin pharmacokinetics but has no effect on tissue drug exposure and pharmacodynamics.
Drug Metab Dispos
; 40(6): 1170-7, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22407892
8.
Characterization of SAGE Mdr1a (P-gp), Bcrp, and Mrp2 knockout rats using loperamide, paclitaxel, sulfasalazine, and carboxydichlorofluorescein pharmacokinetics.
Drug Metab Dispos
; 40(9): 1825-33, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22711747
9.
Development of a rapid and sensitive multiple reaction monitoring proteomic approach for quantification of transporters in human liver tissue.
J Chromatogr B Analyt Technol Biomed Life Sci
; 1061-1062: 356-363, 2017 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28800539
10.
Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
J Med Chem
; 59(24): 10974-10993, 2016 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28002967