Detalhe da pesquisa
1.
Prolonged culture of human pancreatic islets under glucotoxic conditions changes their acute beta cell calcium and insulin secretion glucose response curves from sigmoid to bell-shaped.
Diabetologia
; 66(4): 709-723, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36459178
2.
XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice.
Diabetologia
; 65(6): 984-996, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35316840
3.
Transcriptome analysis of islets from diabetes-resistant and diabetes-prone obese mice reveals novel gene regulatory networks involved in beta-cell compensation and failure.
FASEB J
; 35(6): e21608, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33977593
4.
Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans.
Diabetologia
; 62(12): 2273-2286, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31624901
5.
Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells.
Diabetologia
; 59(7): 1492-1502, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27039902
6.
Inhibitor of differentiation proteins protect against oxidative stress by regulating the antioxidant-mitochondrial response in mouse beta cells.
Diabetologia
; 58(4): 758-70, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25636209
7.
Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse ß-cells by co-ordinating insulin biosynthesis with secretory granule formation.
Mol Metab
; 79: 101845, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38013154
8.
Emerging Roles of Metallothioneins in Beta Cell Pathophysiology: Beyond and Above Metal Homeostasis and Antioxidant Response.
Biology (Basel)
; 10(3)2021 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33652748
9.
Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity.
Nat Commun
; 12(1): 2622, 2021 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33976180
10.
Aspalathin Protects Insulin-Producing ß Cells against Glucotoxicity and Oxidative Stress-Induced Cell Death.
Mol Nutr Food Res
; 64(8): e1901009, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32012427
11.
SGLT2 is not expressed in pancreatic α- and ß-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans.
Mol Metab
; 42: 101071, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32896668
12.
Phlda3 regulates beta cell survival during stress.
Sci Rep
; 9(1): 12827, 2019 09 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31492921
13.
Mechanisms of ß-cell dedifferentiation in diabetes: recent findings and future research directions.
J Endocrinol
; 236(2): R109-R143, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29203573
14.
Y1 receptor deficiency in ß-cells leads to increased adiposity and impaired glucose metabolism.
Sci Rep
; 8(1): 11835, 2018 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30177746
15.
NADPH oxidase-2 does not contribute to ß-cell glucotoxicity in cultured pancreatic islets from C57BL/6J mice.
Mol Cell Endocrinol
; 439: 354-362, 2017 01 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27664519
16.
Inhibition of Y1 receptor signaling improves islet transplant outcome.
Nat Commun
; 8(1): 490, 2017 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28887564
17.
The balance between adaptive and apoptotic unfolded protein responses regulates ß-cell death under ER stress conditions through XBP1, CHOP and JNK.
Mol Cell Endocrinol
; 413: 189-201, 2015 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26135354
18.
Pancreatic PYY Is Critical in the Control of Insulin Secretion and Glucose Homeostasis in Female Mice.
Endocrinology
; 156(9): 3122-36, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26125465
19.
NPY signalling in early osteoblasts controls glucose homeostasis.
Mol Metab
; 4(3): 164-74, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25737952
20.
Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia.
PLoS One
; 10(6): e0128012, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26046931