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1.
J Oral Rehabil ; 51(7): 1184-1192, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38532285

RESUMO

BACKGROUND: It is still discussed whether occlusal wear (OW) affects the formation of non-carious cervical lesions (NCCLs). OBJECTIVE: To estimate effects of OW on the presence and development of NCCLs, using 16-year follow-up data from a cohort study. METHODS: Occlusal and cervical defects were measured in 728 cast models (one from the upper jaw and one from the lower jaw) of 364 participants. Adjusted mixed-effects ordinal logistic models analysing estimated cross-sectional (N = 1308 teeth/291 subjects) and longitudinal (N = 718 teeth/226 subjects) associations of OW with NCCLs using tooth level data. RESULTS: OW size was cross-sectionally (OR = 1.74; 95% CI: 1.27-2.38 for OW size; OR = 0.97; 95% CI: 0.94-0.99 for squared OW size), but not longitudinally (OR = 1.14; 95% CI: 0.99-1.30) associated with odds of higher NCCL sizes. For cross-sectional analyses, predicted probabilities of an NCCL size of 0 decreased from about 0.996 to 0.010 for OW sizes of 0 to 25. CONCLUSION: Results suggest an association between OW and NCCL size. However, as longitudinal results were non-significant, while consistent in direction, large-scaled cohort studies are demanded to more precisely estimate effect strength.


Assuntos
Progressão da Doença , Humanos , Feminino , Masculino , Estudos Transversais , Pessoa de Meia-Idade , Alemanha/epidemiologia , Estudos Longitudinais , Colo do Dente/patologia , Desgaste dos Dentes/patologia , Adulto , Seguimentos , Idoso
2.
Sleep Breath ; 27(1): 389-397, 2023 03.
Artigo em Inglês | MEDLINE | ID: mdl-35349009

RESUMO

PURPOSE: Obstructive sleep apnea (OSA) may result in severe health onditions, reduces quality of live, and affects high percentages of the adult population. Due to recent changes in the German health care regulations, mandibular advancement devices (MAD) will become available as a treatment option for OSA to a greater extent for general dentists and their patients. METHODS: A guideline development group consisting of nine members representing four German dental and medical organizations was formed, in order to provide critical information and orientation to the main stakeholders (dentists and patients), regarding the use of MAD for the treatment of OSA within dental sleep medicine. RESULTS: This guideline aims to inform physicians and dentists, particularly those with acquired qualification/specialization in sleep medicine (or in the diagnosis and treatment of sleep-related breathing disorders), as well as experts, payers, and patients. It delivers recommendations on technical requirements for MAD prescription and fabrication, clinical procedures, maintenance, and follow-up procedures. CONCLUSION: A MAD should be designed for long-term therapy and must be a custom made, adjustable, bimaxillary retained two-splint system equipped with adjustable protrusive elements. The fabrication in a dental laboratory should be based on dental impressions or scans and three-dimensional registrations of the starting position taken with a bite gauge.


Assuntos
Médicos , Apneia Obstrutiva do Sono , Transtornos do Sono-Vigília , Humanos , Adulto , Placas Oclusais , Sono , Apneia Obstrutiva do Sono/diagnóstico , Apneia Obstrutiva do Sono/terapia , Prescrições
3.
Sleep Breath ; 27(2): 459-467, 2023 05.
Artigo em Inglês | MEDLINE | ID: mdl-35486311

RESUMO

PURPOSE: Socioeconomic factors are known to modulate health. Concerning sleep apnea, influences of income, education, work, and living in a partnership are established. However, results differ between national and ethnic groups. Results also differ between various clinical studies and population-based approaches. The goal of our study was to determine if such factors can be verified in the population of Pomerania, Germany. METHODS: A subgroup from the participants of the population-based Study of Health in Pomerania volunteered for an overnight polysomnography. Their data were subjected to an ordinal regressions analysis with age, sex, body mass index (BMI), income, education, work, and life partner as predictors for the apnea-hypopnea index. RESULTS: Among the subgroup (N = 1209) from the population-based study (N = 4420), significant effects were found for age, sex, and BMI. There were no significant effects for any of the socioeconomic factors. CONCLUSION: Significant effects for well-established factors as age, sex, and BMI show that our study design has sufficient power to verify meaningful associations with sleep apnea. The lack of significant effects for the socioeconomic factors suggests their clinical irrelevance in the tested population.


Assuntos
Síndromes da Apneia do Sono , Apneia Obstrutiva do Sono , Humanos , Apneia Obstrutiva do Sono/diagnóstico , Apneia Obstrutiva do Sono/epidemiologia , Apneia Obstrutiva do Sono/complicações , Síndromes da Apneia do Sono/diagnóstico , Síndromes da Apneia do Sono/epidemiologia , Síndromes da Apneia do Sono/complicações , Fatores Socioeconômicos , Polissonografia/métodos , Alemanha , Índice de Massa Corporal
4.
J Oral Rehabil ; 50(10): 921-930, 2023 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-37226632

RESUMO

BACKGROUND: Disc displacement with reduction (DDwR) therapy should be performed only when pain or discomfort is presented. Data on treatment options for painful DDwR are very limited. OBJECTIVE: The aim was to investigate whether isometric training of the lateral pterygoid muscle (LPM) is equivalent to stabilisation appliance therapy with regard to the treatment of painful DDwR. The training program is based on the science of Janda. METHODS: This was a prospective, randomised study with a comparative treatment group. Sixty patients (≥18 years) with DDwR and pain were randomly assigned to two groups: (1) muscle training and (2) stabilisation appliance. The following variables were recorded at baseline examination and after 2, 4 and 6 months: changes in orofacial pain, clicking sounds of the temporomandibular joint (TMJ), force degrees for the lateral movement of the mandible and interincisal opening distance. p values of <.05 were considered statistically significant but 95% confidence intervals were also presented. RESULTS: A decrease in orofacial pain intensity was seen in both groups (p < .0001). Registered TMJ clicking disappeared after 6 months of treatment in 37% (n = 11) of the patients in the training group and in 27% (n = 8) of the appliance group (p = .0009 and p = .0047). Muscle training showed 27 improvements in Janda force degrees at the end of the study (p < .0001). CONCLUSION: Muscle training and appliance therapy improved mouth opening and reduced pain intensity in both patient groups. Muscle training might be a promising option in the treatment of patients suffering from painful DDwR.


Assuntos
Doenças das Cartilagens , Luxações Articulares , Transtornos da Articulação Temporomandibular , Humanos , Disco da Articulação Temporomandibular , Músculos Pterigoides , Estudos Prospectivos , Transtornos da Articulação Temporomandibular/terapia , Transtornos da Articulação Temporomandibular/diagnóstico , Articulação Temporomandibular , Dor Facial/terapia , Luxações Articulares/terapia , Imageamento por Ressonância Magnética
5.
J Oral Rehabil ; 47(2): 164-169, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31430389

RESUMO

As yet, there are still no evidence-based clinical diagnostic and management guidelines for ambulatory single-channel EMG devices, like the BUTLER® GrindCare® (GrindCare), that are used in patients with sleep bruxism. Therefore, a consensus meeting was organised with GrindCare developers, researchers, and academic and non-academic clinicians experienced with the use of ambulatory EMG devices. The aim of the meeting was to discuss and develop recommendations for clinical guidelines for GrindCare usage, based on the existing clinical and research experience of the consensus meeting's participants. As an important outcome of the consensus meeting, clinical guidelines were proposed in which an initial 2-week baseline phase with the device in its inactive (non-stimulus) mode for habituation and assessment of the number of jaw-muscle activities is followed by a 4-week active phase with contingent electrical stimuli suppressing the jaw-muscle activities. As to avoid the commonly reported reduction in sensitivity to the stimuli, a 2-week inactive phase is subsequently installed, followed by a repetition of active and inactive phases until a lasting reduction in the number of jaw-muscle activities and/or associated complaints has been achieved. This proposal has the characteristics of a single-patient clinical trial. From a research point of view, adoption of this approach by large numbers of GrindCare users creates a great opportunity to recruit relatively large numbers of study participants that follow the same protocol.


Assuntos
Bruxismo , Terapia por Estimulação Elétrica , Bruxismo do Sono , Consenso , Estimulação Elétrica , Eletromiografia , Humanos
6.
J Clin Periodontol ; 46(2): 144-159, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-30636328

RESUMO

AIM: We aimed to investigate associations between malocclusions and periodontal disease by comparing it to that of smoking in subjects recruited from the population-based cross-sectional study "Study of Health in Pomerania." MATERIALS AND METHODS: Sagittal intermaxillary relationship, variables of malocclusion and socio-demographic parameters of 1,202 dentate subjects, 20-39 years of age, were selected. Probing depth (PD) and attachment loss (AL) were assessed at four sites by tooth in a half-mouth design. Analyses were performed with multilevel models on subject, jaw and tooth level. RESULTS: Distal occlusion determined in the canine region, ectopic position of canines, anterior spacing, deep anterior overbite and increased sagittal overjet were associated with AL (p-value <0.05). Associations between malocclusions and PD: deep anterior overbite with gingival contact (odds ratio [OR] = 1.40, 95% CI: 1.08-1.82; p-value = 0.0101) and anterior crossbite (OR = 1.75, 95% CI: 1.29-2.38; p-value = 0.0003). Regarding crowding, only severe anterior crowding was compatible with a moderate to large association with PD (OR = 1.93, 95% CI: 0.89-4.20). Compared to smoking, the overall effect of malocclusions was about one half for AL and one-third for PD. CONCLUSION: Malocclusions or morphologic parameters were associated with periodontal disease.


Assuntos
Má Oclusão , Doenças Periodontais , Adulto , Estudos Transversais , Oclusão Dentária , Humanos , Adulto Jovem
7.
J Oral Rehabil ; 46(4): 310-320, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30472782

RESUMO

BACKGROUND: Associations of alexithymia with temporomandibular pain disorders (TMD), facial pain, head pain and migraine have been described, but the role of the different dimensions of alexithymia in pain development remained incompletely understood. OBJECTIVES: We sought to investigate the associations of alexithymia and its subfactors with signs of TMD and with facial pain, head pain and migraine in the general population. METHODS: A total of 1494 subjects from the general population completed the Toronto Alexithymia Scale-20 (TAS-20) and underwent a clinical functional examination with palpation of the temporomandibular joint and masticatory muscles. Facial pain, migraine and head pain were defined by questionnaire. A set of logistic regression analyses was applied with adjustment for age, sex, education, number of traumatic events, depressive symptoms and anxiety. RESULTS: Alexithymia was associated with TMD joint pain (Odds Ratio 2.63; 95% confidence interval 1.60-4.32 for 61 TAS-20 points vs the median of the TAS-20 score) and with facial pain severity (Odds Ratio 3.22; 95% confidence interval 1.79-5.79). Differential effects of the subfactors were discovered with difficulties in identifying feelings as main predictor for joint, facial, and head pain, and externally oriented thinking (EOT) as U-shaped and strongest predictor for migraine. CONCLUSION: Alexithymia was moderately to strongly associated with signs and symptoms of TMD. These results should encourage dental practioners using the TAS-20 in clinical practice, to screen TMD, facial or head pain patients for alexithymia and could also help treating alexithymic TMD, facial or head pain patients.


Assuntos
Sintomas Afetivos/epidemiologia , Dor Facial/epidemiologia , Cefaleia/epidemiologia , Transtornos da Articulação Temporomandibular/epidemiologia , Adulto , Sintomas Afetivos/fisiopatologia , Sintomas Afetivos/psicologia , Idoso , Idoso de 80 Anos ou mais , Estudos de Coortes , Dor Facial/fisiopatologia , Dor Facial/psicologia , Feminino , Seguimentos , Alemanha/epidemiologia , Cefaleia/fisiopatologia , Cefaleia/psicologia , Humanos , Masculino , Pessoa de Meia-Idade , Razão de Chances , Medição da Dor , Palpação/efeitos adversos , Prevalência , Transtornos da Articulação Temporomandibular/fisiopatologia , Transtornos da Articulação Temporomandibular/psicologia
8.
Int J Comput Dent ; 22(4): 353-362, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31840143

RESUMO

The articulation parameters, especially the horizontal condylar inclination angle (HCI), the Bennett angle (BA), and the immediate side shift (ISS) were determined in 259 subjects (100 males; 159 females) of the associated project with reference to the population-representative baseline study (Study of Health in Pomerania, SHIP 0). The evaluations were based on a clinical functional status and electronic motion recording with the ultrasonic measuring system Jaw Motion Analyser (JMA, Zebris, Isny, Germany). The reference plane, to which all measured values were represented and the HCI calculated, was the hinge axis infraorbital plane (HA-IOP). The HCI was determined after an excursive movement with a length of 4 mm to the HA-IOP in the sagittal view and the BA after a mediotrusive excursion movement of 6 mm in the horizontal view to the midsagittal plane. For the standard and limit values, the average value in addition to the standard deviation and the 10th and 90th percentile value (10th percentile value, 90th percentile value) were determined: HCI right 52.1 ± 10.14 degrees (39.4 degrees, 64.0 degrees), HCI left 53.1 ± 9.67 degrees (42.3 degrees, 67.0 degrees), BA right 15.2 ± 7.53 degrees (6.7 degrees, 25.0 degrees), BA left 14.2 ± 7.84 degrees (5.4 degrees, 24.1 degrees). The HCI was approximately 2 to 3 degrees larger in females (males: right 50.5 ± 9.47 degrees, left 51.9 ± 8.99 degrees; females: right 53.1 ± 10.42 degrees, left 53.8 ± 10.03 degrees). Likewise, the BA in the age group ≥ 40 years (males: right 14.4 ± 6.62 degrees, left 13.1 ± 7.14 degrees; females: right 17.0 ± 9.02 degrees, left 16.9 ± 8.72 degrees). The latter proved to be statistically significant in the t test for independent samples, assuming variance equivalence on the right, with P = 0.009, and with rejection of the variant equivalence on the left, with P = 0.002. The right and left HCI and BA joint values showed highly significant linear dependence at P < 0.001, but rather low, however, for the HCI with r2 = 0.175 for the HCI and r2 = 0.228 for the BA. In 46% of cases, the right and left HCI values differed up to 5 degrees only; a further 20.9% were in an interval difference of between 5 and 10 degrees. The following results were shown for the differences in the BA: 56.4% of the cases were between 0 and 5 degrees, and 26.2% were in the interval ranges of 5 to 10 degrees. ISS occurred in 18.1% of cases on the right side of the joint, and in 27.8% of cases on the left side. On both sides of the joint it was significantly more frequent in the age group ≥ 40 years with assumed variance equality than in the age group < 40 years (P = 0.002 right, P = 0.003 left). The groups relating to the Helkimo index (HI) did not differ significantly in all function-specific parameters. If it is assumed that there is no significant influence on the occlusion if the HCI values differ by 7 to 8 degrees from the average value, only approximately one third of all cases (35.1%) were characterized by a purely average value setting in the articulator. In 41.7% of cases, one joint value was situated outside the average value range; in 23.2% of the cases both values were outside the average value range. Without a measurement of the condylar path inclination, however, it is impossible to decide to what extent the HCI deviates from the average value, and which joint side is larger or smaller than the other and to what extent. These results suggest that in extensive and complex cases, the articulator should be adjusted according to individual, function-specific joint values.


Assuntos
Côndilo Mandibular , Articulação Temporomandibular , Feminino , Alemanha , Humanos , Registro da Relação Maxilomandibular , Masculino , Amplitude de Movimento Articular
9.
Int J Comput Dent ; 18(3): 201-23, 2015.
Artigo em Inglês, Alemão | MEDLINE | ID: mdl-26389133

RESUMO

Mandibular movement recording has long been established as the method for the physiological design of indirect dental restorations. Condylar movement recording is the basis for individual, patient-specific programming of partially or fully adjustable articulators. The settings derived from these recordings can generally be used in both traditional mechanical and electronic virtual articulators. For many years, condylar movement recordings have also provided useful information about morphological conditions in the temporomandibular joints (TMJs) of patients with masticatory system dysfunction based on the recorded movement patterns. The latest clinical application for recorded jaw-motion analysis data consists of functional monitoring of the patient as a diagnostic and surveillance tool accompanying treatment. Published parameters for the analysis of such recordings already exist, but a standardized and practicable protocol for the documentation and analysis of such jaw-movement recordings is still lacking. The aim of this article by a multicenter consortium of authors is to provide an appropriate protocol with the documentation criteria needed to meet the requirements for standardized analysis of computer-assisted recording of condylar movements in the future.


Assuntos
Oclusão Dentária , Registro da Relação Maxilomandibular/instrumentação , Mandíbula/fisiologia , Côndilo Mandibular/fisiologia , Amplitude de Movimento Articular/fisiologia , Software , Calibragem , Desenho Assistido por Computador , Articuladores Dentários , Desenho de Equipamento , Humanos , Movimento , Articulação Temporomandibular/fisiologia , Transtornos da Articulação Temporomandibular/diagnóstico , Interface Usuário-Computador
10.
Medicina (Kaunas) ; 51(4): 228-32, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26424187

RESUMO

OBJECTIVE: The aim of the study was to verify the influence of a genetic factor on the etiology of oral bony outgrowths and to determine the prevalence and type of oral bony outgrowths (tori and exostoses) among a group of Lithuanian twins. MATERIALS AND METHODS: In total, 162 twins (81 twin pairs) were analyzed for the presence or absence, type, and size of oral bony outgrowths. Statistical analysis was carried out to find the prevalence of bony protuberances and the relationship between zygosity and occurrence of oral bony enlargements. Zygosity of twins was confirmed by DNA analysis. RESULTS: 59.9% of the subjects had oral bony outgrowths. Mandibular tori were found in 56.8% and palatal tori in 1.8% of the sample. Palatal exostoses and mandibular exostoses were present in 1.8% and 3.1% of the sample, respectively, whereas maxillary exostoses were not found. A higher percentage of tori and exostoses were found in the group of older subjects (>18 years old, p=0.025). No significant difference was found between men and women in the prevalence of bony outgrowths. High κ and r values (0.91±0.062) showed very good concordance of oral bony outgrowths between monozygotic and moderate concordance (0.58±0.141) between dizygotic co-twins (p<0.001). The calculation of heritability estimate verifies dominant influence of genetic factor on the etiology of oral bony outgrowths (h(2)=0.658). CONCLUSION: The most common bony outgrowth was torus mandibularis. Our results show that the genetic factor is dominant in the etiology of oral bony outgrowths.


Assuntos
Exostose/epidemiologia , Exostose/genética , Mandíbula/anormalidades , Palato Duro/anormalidades , Adolescente , Adulto , Criança , Feminino , Humanos , Lituânia/epidemiologia , Masculino , Pessoa de Meia-Idade , Prevalência , Gêmeos Dizigóticos , Adulto Jovem
11.
J Clin Med ; 12(6)2023 Mar 07.
Artigo em Inglês | MEDLINE | ID: mdl-36983104

RESUMO

Objective: Menopause is associated with multiple health risks. In several studies, a higher incidence or a higher risk for obstructive sleep apnea (OSA) in post-menopausal than pre-menopausal women is reported. This study was designed to verify such a connection between menopause and OSA in a population-based sample. Methods: For a subsample (N = 1209) of the Study of Health in Pomerania (N = 4420), complete polysomnography data was available. Of these, 559 females completed a structured interview about their menstrual cycle. Splines and ordinal regression analysis were used to analyze the resulting data. Results: In the ordinal regression analysis, a significant association between the apnea-hypopnea index (AHI) and menopause indicated that post-menopausal women had a substantially higher risk of OSA. In accordance with previous studies, risk indicators such as body mass index (BMI), age, and the influence of hysterectomies or total oophorectomies were included in the model. Conclusions: Our results clearly confirmed the assumed connection between menopause and OSA. This is important because OSA is most often associated with male patients, and it warrants further research into the underlying mechanisms.

12.
J Clin Periodontol ; 39(12): 1115-24, 2012 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23061920

RESUMO

OBJECTIVES: To compare the prevalence of periodontal disease between two randomly selected population-based studies (the Oral Infections and Vascular Disease Epidemiology Study (INVEST) and the Study of Health in Pomerania (SHIP)) and address relevant methodological issues. METHODS: Comparison was restricted to 55- to 81-year olds. Attachment loss (AL), probing depth (PD) and tooth count were assessed in INVEST (full-mouth, six sites) and SHIP (half-mouth, four sites). Subjects were classified according to the CDC/AAP case definition. Recording protocols were standardized. Mixed linear or logistic models were used to compare INVEST with SHIP. RESULTS: Mean half-mouth AL was lower in INVEST versus SHIP (INVEST: 2.9 mm versus SHIP: 4.0 mm, p < 0.05). Findings were similar across multiple periodontal disease definitions. After equalization of recording protocols and adjustment for periodontal risk factors, mean AL and PD were 1.2 and 0.3 mm lower in INVEST versus SHIP (p < 0.001). The odds for severe periodontitis (CDC/AAP) was 0.2-fold in INVEST versus SHIP (p < 0.001). Confounding effects of age, gender, race/ethnicity, education and use of interdental care devices were highest as indicated by change-in-estimate for study. CONCLUSION: Implementation of the proposed method for comparison of epidemiological studies revealed that periodontitis was less prevalent in INVEST compared with SHIP, even after extensive risk-factor adjustment.


Assuntos
Inquéritos de Saúde Bucal/métodos , Periodontite/epidemiologia , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Distribuição de Qui-Quadrado , Estudos de Coortes , Comparação Transcultural , Etnicidade , Feminino , Alemanha/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Cidade de Nova Iorque/epidemiologia , Higiene Bucal/instrumentação , Perda da Inserção Periodontal/epidemiologia , Índice Periodontal , Prevalência , Estudos Prospectivos , Análise de Regressão , Fatores de Risco , Fatores Sexuais , Estatísticas não Paramétricas , População Branca
13.
J Orofac Orthop ; 82(5): 295-312, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-33337523

RESUMO

PURPOSE: Only a few but conflicting results have been reported on the association between malocclusions and caries. We investigated this association using data from the population-based cross-sectional Study of Health in Pomerania (SHIP). METHODS: Sagittal, vertical and transversal intermaxillary relationship, space conditions and sociodemographic parameters of 1210 dentate subjects (median age 30 years, interquartile range 25-35 years) were collected. Caries was assessed with the Decayed-Missing-Filled Surfaces index but analyzed as ordered outcome (four levels: sound, enamel caries, caries, tooth loss) in ordinal multilevel models, taking into account subject, jaw, and tooth level simultaneously. RESULTS: Anterior open bite ≤3 mm (odds ratio [OR] = 2.08, 95% confidence interval [CI]: 1.19-3.61), increased sagittal overjet of 4-6 mm (OR = 1.31, CI: 1.05-1.64), distal occlusion of ½ premolar width (OR = 1.27, CI: 1.05-1.53) and distal 1 premolar width (OR = 1.31, CI: 1.06-1.63) were associated with adjusted increased odds for a higher outcome level (caries). Anterior spacing (OR = 0.24, CI: 0.17-0.33), posterior spacing, (OR = 0.69, CI: 0.5-0.95), posterior crowding (OR = 0.57, CI: 0.49-0.66) and buccal nonocclusion (OR = 0.54, CI: 0.33-0.87) were associated with a lower outcome level (caries). CONCLUSION: The results from this population-based study suggest that a connection between caries and malocclusion exists to a limited extent in young adults. The associations with caries are contradictory for several malocclusion variables. Distal occlusion (OR = 1.31, CI: 1.06-1.63) and related skeletal anomalies displayed positive associations with caries whereas crowding did not. Orthodontic treatment of anterior crowding would probably not interfere with caries experience. These aspects should be considered for patient information and in treatment decisions.


Assuntos
Cárie Dentária , Má Oclusão , Mordida Aberta , Adulto , Estudos Transversais , Cárie Dentária/epidemiologia , Suscetibilidade à Cárie Dentária , Humanos , Má Oclusão/epidemiologia , Adulto Jovem
14.
Community Dent Oral Epidemiol ; 48(5): 364-370, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-32420644

RESUMO

OBJECTIVES: To examine the association between third molars and orofacial pain. We hypothesized that impacted third molars are a cause of orofacial pain. METHODS: Magnetic resonance images of 1808 participants from two population-based cohorts from Northeastern Germany were analysed to define the status of third molars according to the Pell and Gregory classification. A self-reported questionnaire and a clinical dental examination were used to detect chronic and acute complaints of orofacial pain, masticatory muscle pain, migraine and other types of headache. Logistic regression models were used to analyse the associations between third molar status and orofacial pain. RESULTS: Individuals with impacted third molars in the maxilla had a higher chance of chronic orofacial pain than those with erupted third molars (odds ratio 2.19; 95% CI 1.19-4.02). No such association was detected for third molars in the lower jaw. Third molars were not associated with masticatory muscle pain, migraine or other types of headache. CONCLUSIONS: Impacted maxillary third molars might be a cause of chronic orofacial pain. Thus, physicians should consider the eruption/impaction status of third molars in their decision-making process when treating patients who complain of orofacial pain.


Assuntos
Dente Serotino , Dente Impactado , Dor Facial/epidemiologia , Dor Facial/etiologia , Alemanha , Humanos , Mandíbula , Dente Impactado/epidemiologia
15.
J Oral Facial Pain Headache ; 33(1): 67­76, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30153313

RESUMO

AIMS: To estimate the association between signs of temporomandibular disorders (TMD) and symptoms of posttraumatic stress disorder (PTSD) in a representative sample from the general population of northeastern Germany. METHODS: Signs of TMD were assessed with a clinical functional analysis that included palpation of the temporomandibular joints (TMJs) and masticatory muscles. PTSD was assessed with the PTSD module of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, ed 4. The change-in-estimate method for binary logistic regression models was used to determine the final model and control for confounders. RESULTS: After the exclusion of subjects without prior traumatic events, the sample for joint pain consisted of 1,673 participants with a median age of 58.9 years (interquartile range 24.8), and the sample for muscle pain consisted of 1,689 participants with a median age of 59.1 years (interquartile range 24.8). Of these samples, 84 participants had pain on palpation of the TMJ, and 42 participants had pain on palpation of the masticatory muscles. Subjects having clinical PTSD (n = 62) had a 2.56-fold increase in joint pain (odds ratio [OR] = 2.56; 95% confidence interval [CI]: 1.14 to 5.71, P = .022) and a 3.86-fold increase (OR = 3.86; 95% CI: 1.51 to 9.85, P = .005) in muscle pain compared to subjects having no clinical PTSD. CONCLUSION: These results should encourage general practitioners and dentists to acknowledge the role of PTSD and traumatic events in the diagnosis and therapy of TMD, especially in a period of international migration and military foreign assignments.


Assuntos
Transtornos de Estresse Pós-Traumáticos , Transtornos da Articulação Temporomandibular , Adulto , Dor Facial , Alemanha , Humanos , Músculos da Mastigação , Adulto Jovem
16.
Pain ; 160(3): 579-591, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30431558

RESUMO

Painful temporomandibular disorders (TMDs) are the leading cause of chronic orofacial pain, but its underlying molecular mechanisms remain obscure. Although many environmental factors have been associated with higher risk of developing painful TMD, family and twin studies support a heritable genetic component as well. We performed a genome-wide association study assuming an additive genetic model of TMD in a discovery cohort of 999 cases and 2031 TMD-free controls from the Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA) study. Using logistic models adjusted for sex, age, enrollment site, and race, we identified 3 distinct loci that were significant in combined or sex-segregated analyses. A single-nucleotide polymorphism on chromosome 3 (rs13078961) was significantly associated with TMD in males only (odds ratio = 2.9, 95% confidence interval: 2.02-4.27, P = 2.2 × 10). This association was nominally replicated in a meta-analysis of 7 independent orofacial pain cohorts including 160,194 participants (odds ratio = 1.16, 95% confidence interval: 1.0-1.35, P = 2.3 × 10). Functional analysis in human dorsal root ganglia and blood indicated this variant is an expression quantitative trait locus, with the minor allele associated with decreased expression of the nearby muscle RAS oncogene homolog (MRAS) gene (beta = -0.51, P = 2.43 × 10). Male mice, but not female mice, with a null mutation of Mras displayed persistent mechanical allodynia in a model of inflammatory pain. Genetic and behavioral evidence support a novel mechanism by which genetically determined MRAS expression moderates the resiliency to chronic pain. This effect is male-specific and may contribute to the lower rates of painful TMD in men.


Assuntos
Dor Facial/etiologia , Polimorfismo de Nucleotídeo Único/genética , Transtornos da Articulação Temporomandibular/complicações , Transtornos da Articulação Temporomandibular/genética , Proteínas ras/genética , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Animais , Estudos de Coortes , Modelos Animais de Doenças , Estudos de Associação Genética , Estudo de Associação Genômica Ampla , Genótipo , Humanos , Masculino , Camundongos , Camundongos Knockout , Pessoa de Meia-Idade , RNA Mensageiro/metabolismo , Adulto Jovem , Proteínas ras/deficiência
18.
J Orofac Pain ; 21(1): 29-38, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17312639

RESUMO

AIMS: To test in vitro and in vivo the reliability and accuracy of a new algometer, the pressure algometer for palpation (PAP), for measuring pressure pain thresholds (PPTs) and to compare its features with those of a commercially available pressure algometer. METHODS: For in vitro accuracy testing, 6 repeated measurements were made at 8 defined test weights from 0.5 to 5 lb. In vivo validity testing compared the PAP to a standard instrument, the hand-held Somedic algometer, at 16 sites including the masticatory muscles, the temporomandibular joints, and the frontalis (as the control site) in 15 temporomandibular disorder (TMD) cases and 15 controls. Intraexaminer reliability was also assessed for both algometers. RESULTS: In vitro reliability was high, with coefficients of variation of < 5% and a single-measurement standard deviation of 2.1 kPa. Accuracy was also high, with PAP measurements correlating with test weights at r = .99 (P < .001). Repeated measures reliability in vivo was high, with intraclass correlation estimates of 0.73 to 0.96 for the PAP and 0.78 to 0.99 for the Somedic algometer. PPT values correlated moderately between the 2 devices (r ranged from 0.38 to 0.66; P < or = .05) and were consistently higher for the PAP at all sites (P < .001). Differences between controls and TMD cases were also significant for both algometers (P < .006). CONCLUSION: Both the PAP and the Somedic algometer showed high reliability. Concurrent validity was demonstrated by statistically significant correlations between the devices. Both showed equally high capacity for differentiating TMD cases from controls. The PAP yielded significantly higher PPTs than the Somedic algometer.


Assuntos
Músculos da Mastigação/fisiopatologia , Medição da Dor/instrumentação , Limiar da Dor/fisiologia , Articulação Temporomandibular/fisiopatologia , Adulto , Estudos de Casos e Controles , Desenho de Equipamento , Músculos Faciais/fisiopatologia , Feminino , Testa , Humanos , Masculino , Músculo Masseter/fisiopatologia , Variações Dependentes do Observador , Palpação/instrumentação , Pressão , Amplitude de Movimento Articular/fisiologia , Reprodutibilidade dos Testes , Músculo Temporal/fisiopatologia , Transtornos da Articulação Temporomandibular/fisiopatologia , Transdutores de Pressão
19.
Ann Anat ; 189(4): 342-6, 2007.
Artigo em Inglês | MEDLINE | ID: mdl-17695989

RESUMO

The aim of this study is to investigate associations between degenerative bony changes of the temporomandibular joint (TMJ) evaluated by magnetic resonance imaging (MRI) and signs and symptoms of temporomandibular disorders (TMD) in a non-patient group. A total of 307 subjects (140 males and 167 females) were selected from the cross-sectional epidemiological study "Study of Health in Pomerania" (SHIP) for this evaluation. A clinical functional examination of the masticatory muscles and the TMJs was performed as well as an MRI examination of the TMJs. Another 77 subjects (25%) exhibited degenerative changes of one or both TMJs in the MRI. Clinical analysis revealed pain on palpation of the masticatory muscles in 113 subjects. Some 39 subjects had pain during palpation of the TMJs. There were significant associations between the MRI confirmed diagnosis of osteoarthrosis and some clinical signs (joint noises, joint palpation pain, reduced mouth opening) and symptoms (reported pain in the jaw and masticatory muscles) of TMD as well as further MRI diagnoses (disc displacement with and without reduction, fibrosis of the posterior ligament). Although there were some associations, clinical examination alone is not sufficient for diagnosing degenerative joint diseases. MRI is a necessary diagnostic adjunct for estimating the prevalence of TMD subgroups in non-patient populations.


Assuntos
Transtornos da Articulação Temporomandibular/patologia , Articulação Temporomandibular/anatomia & histologia , Adulto , Auscultação , Estudos Transversais , Feminino , Humanos , Arcada Osseodentária/anatomia & histologia , Arcada Osseodentária/fisiologia , Arcada Osseodentária/fisiopatologia , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Atividade Motora , Boca , Dor , Pressão , Valores de Referência , Transtornos da Articulação Temporomandibular/fisiopatologia
20.
J Periodontol ; 77(3): 506-16, 2006 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-16512766

RESUMO

BACKGROUND: The purpose of this study was to investigate potential associations between dynamic occlusal interferences and signs of periodontal disease in posterior teeth based on dental and medical measurements obtained from a population-based sample in the cross-sectional epidemiological study entitled, "Study of Health in Pomerania" (SHIP). METHODS: Medical history and dental and sociodemographic parameters of 2,980 representatively selected dentate subjects, 20 to 79 years of age, were collected. The analysis was performed on posterior teeth only using a mixed linear model that considers the clustered structure of the data. The model also was adjusted with respect to known risk factors for periodontal disease. RESULTS: The presence of non-working side contacts only was significantly related to probing depth (P<0.0001) and attachment loss (P=0.001). The presence of non-working side contacts and working side contacts on the same tooth was significantly related to increased probing depth (P=0.004) but not attachment level. The effect magnitude was a mean increase of 0.13 mm for probing depth and 0.14 mm in attachment loss. Known risk factors for periodontal disease that also showed significant associations with probing depth and attachment loss included male gender, age, smoking, education, and plaque score. Other factors significantly related to probing depth and/or attachment loss were tilted teeth, restored occlusal surfaces versus sound surfaces, elongated teeth, and tooth type (molar versus premolar). CONCLUSION: The effect of non-working contacts on periodontal disease status was discernible, but weak in terms of magnitude and specificity.


Assuntos
Oclusão Dentária Traumática/complicações , Perda da Inserção Periodontal/etiologia , Bolsa Periodontal/etiologia , Adulto , Idoso , Bruxismo/complicações , Estudos Transversais , Oclusão Dentária Traumática/epidemiologia , Placa Dentária/complicações , Escolaridade , Feminino , Alemanha/epidemiologia , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Perda da Inserção Periodontal/epidemiologia , Bolsa Periodontal/epidemiologia , Fatores de Risco , Fumar/efeitos adversos , Atrito Dentário/complicações
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