Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros

Base de dados
País/Região como assunto
Ano de publicação
Tipo de documento
País de afiliação
Intervalo de ano de publicação
1.
Nat Commun ; 15(1): 2198, 2024 Mar 19.
Artigo em Inglês | MEDLINE | ID: mdl-38503727

RESUMO

Metastasis arises from disseminated tumour cells (DTCs) that are characterized by intrinsic phenotypic plasticity and the capability of seeding to secondary organs. DTCs can remain latent for years before giving rise to symptomatic overt metastasis. In this context, DTCs fluctuate between a quiescent and proliferative state in response to systemic and microenvironmental signals including immune-mediated surveillance. Despite its relevance, how intrinsic mechanisms sustain DTCs plasticity has not been addressed. By interrogating the epigenetic state of metastatic cells, we find that tumour progression is coupled with the activation of oncogenic enhancers that are organized in variable interconnected chromatin domains. This spatial chromatin context leads to the activation of a robust transcriptional response upon repeated exposure to retinoic acid (RA). We show that this adaptive mechanism sustains the quiescence of DTCs through the activation of the master regulator SOX9. Finally, we determine that RA-stimulated transcriptional memory increases the fitness of metastatic cells by supporting the escape of quiescent DTCs from NK-mediated immune surveillance. Overall, these findings highlight the contribution of oncogenic enhancers in establishing transcriptional memories as an adaptive mechanism to reinforce cancer dormancy and immune escape, thus amenable for therapeutic intervention.


Assuntos
Vigilância Imunológica , Sequências Reguladoras de Ácido Nucleico , Divisão Celular , Linhagem Celular Tumoral , Cromatina
2.
Ig Sanita Pubbl ; 67(1): 27-40, 2011.
Artigo em Italiano | MEDLINE | ID: mdl-21468152

RESUMO

This study evaluated the proportion of food samples, examined by the Italian Istituti Zooprofilattici Sperimentali (Experimental Zooprophylactic Institutes) in the years 2000-2005, positive for Campylobacter and Listeria. A correlation was found between food samples found positive for Listeria in the years 2002-2005 and the number of hospitalisations for Listeria illness in the same years (as reported in hospital discharge abstract forms). This confirms that attention should be given in the evaluation of phenomena known to be under reported and for which data are collected and analysed by different methods.


Assuntos
Campylobacter/isolamento & purificação , Doenças Transmissíveis Emergentes/epidemiologia , Contaminação de Alimentos/estatística & dados numéricos , Microbiologia de Alimentos , Listeria/isolamento & purificação , Infecções por Campylobacter/epidemiologia , Infecções por Campylobacter/transmissão , Hospitalização/estatística & dados numéricos , Humanos , Itália , Listeriose/epidemiologia , Listeriose/transmissão , Prevalência
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA