Neuroscience: Seq-ing maps in the olfactory cortex.

Many cortical brain regions are spatially organized to optimize sensory representation. Such topographic maps have so far been elusive in the olfactory cortex. A high-throughput tracing study reveals that the neural circuits connecting olfactory regions are indeed topographically organized.

Gigapixel imaging with a novel multi-camera array microscope.

The dynamics of living organisms are organized across many spatial scales. However, current cost-effective imaging systems can measure only a subset of these scales at once. We have created a scalable multi-camera array microscope (MCAM) that enables comprehensive high-resolution recording from multiple spatial scales simultaneously, ranging from structures that approach the cellular scale to large-group behavioral dynamics. By collecting data from up to 96 cameras, we computationally generate gigapixel-scale images and movies with a field of view over hundreds of square centimeters at an optical resolution of 18 µm. This allows us to observe the behavior and fine anatomical features of numerous freely moving model organisms on multiple spatial scales, including larval zebrafish, fruit flies, nematodes, carpenter ants, and slime mold. Further, the MCAM architecture allows stereoscopic tracking of the z-position of organisms using the overlapping field of view from adjacent cameras. Overall, by removing the bottlenecks imposed by single-camera image acquisition systems, the MCAM provides a powerful platform for investigating detailed biological features and behavioral processes of small model organisms across a wide range of spatial scales.

Neuroscience: Illuminating Principles of Odor Coding.

Neuroscientists still are not sure what makes any two odors smell alike. A new study uses light to manipulate the sensory cells in our nose that respond to odors and reveals that both the timing and identity of activated cells influence odor perception.

Odor coding in piriform cortex: mechanistic insights into distributed coding.

Olfaction facilitates a large variety of animal behaviors such as feeding, mating, and communication. Recent work has begun to reveal the logic of odor transformations that occur throughout the olfactory system to form the odor percept. In this review, we describe the coding principles and mechanisms by which the piriform cortex and other olfactory areas encode three key odor features: odor identity, intensity, and valence. We argue that the piriform cortex produces a multiplexed odor code that allows non-interfering representations of distinct features of the odor stimulus to facilitate odor recognition and learning, which ultimately drives behavior.