Detalhe da pesquisa
1.
Assessment of pegylated arginine deiminase and modified FOLFOX6 in patients with advanced hepatocellular carcinoma: Results of an international, single-arm, phase 2 study.
Cancer
; 127(24): 4585-4593, 2021 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34415578
2.
Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase-Mediated Eukaryotic Initiation Factor 2α Activity and Is Targetable by Pegylated Arginine Deiminase.
Am J Pathol
; 187(1): 200-213, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27979310
3.
A phase 1/1B trial of ADI-PEG 20 plus nab-paclitaxel and gemcitabine in patients with advanced pancreatic adenocarcinoma.
Cancer
; 123(23): 4556-4565, 2017 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28832976
4.
Arginine deprivation using pegylated arginine deiminase has activity against primary acute myeloid leukemia cells in vivo.
Blood
; 125(26): 4060-8, 2015 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25896651
5.
Imaging of tumor vascularization using fluorescence molecular tomography to monitor arginine deiminase treatment in melanoma.
Mol Imaging
; 12(1): 67-73, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23348793
6.
Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma.
Invest New Drugs
; 31(2): 425-34, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22864522
7.
Discovery and Targeting of a Noncanonical Mechanism of Sarcoma Resistance to ADI-PEG20 Mediated by the Microenvironment.
Clin Cancer Res
; 29(16): 3189-3202, 2023 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37339179
8.
Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism.
Cell Rep Med
; 3(1): 100498, 2022 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35106510
9.
Pilot Trial of Arginine Deprivation Plus Nivolumab and Ipilimumab in Patients with Metastatic Uveal Melanoma.
Cancers (Basel)
; 14(11)2022 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35681616
10.
A Phase 1 study of ADI-PEG20 (pegargiminase) combined with cisplatin and pemetrexed in ASS1-negative metastatic uveal melanoma.
Pigment Cell Melanoma Res
; 35(4): 461-470, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35466524
11.
Phase I study of ADI-PEG20 plus low-dose cytarabine for the treatment of acute myeloid leukemia.
Cancer Med
; 10(9): 2946-2955, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33787078
12.
Phase 1b study of pegylated arginine deiminase (ADI-PEG 20) plus Pembrolizumab in advanced solid cancers.
Oncoimmunology
; 10(1): 1943253, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34290906
13.
Phase II Study of Arginine Deprivation Therapy With Pegargiminase in Patients With Relapsed Sensitive or Refractory Small-cell Lung Cancer.
Clin Lung Cancer
; 21(6): 527-533, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32859536
14.
Exploiting Arginine Auxotrophy with Pegylated Arginine Deiminase (ADI-PEG20) to Sensitize Pancreatic Cancer to Radiotherapy via Metabolic Dysregulation.
Mol Cancer Ther
; 18(12): 2381-2393, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31395686
15.
MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion.
Clin Cancer Res
; 25(16): 5107-5121, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31164374
16.
A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma.
Clin Cancer Res
; 25(9): 2708-2716, 2019 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30796035
17.
Argininosuccinate Synthetase-1 (ASS1) Loss in High-Grade Neuroendocrine Carcinomas of the Urinary Bladder: Implications for Targeted Therapy with ADI-PEG 20.
Endocr Pathol
; 29(3): 236-241, 2018 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-29453600
18.
A Phase II Study of Arginine Deiminase (ADI-PEG20) in Relapsed/Refractory or Poor-Risk Acute Myeloid Leukemia Patients.
Sci Rep
; 7(1): 11253, 2017 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28900115
19.
Arginine Deprivation With Pegylated Arginine Deiminase in Patients With Argininosuccinate Synthetase 1-Deficient Malignant Pleural Mesothelioma: A Randomized Clinical Trial.
JAMA Oncol
; 3(1): 58-66, 2017 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27584578
20.
Pegylated arginine deiminase treatment of patients with metastatic melanoma: results from phase I and II studies.
J Clin Oncol
; 23(30): 7660-8, 2005 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16234528