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1.
BMC Ophthalmol ; 22(1): 152, 2022 Apr 02.
Artigo em Inglês | MEDLINE | ID: mdl-35366846

RESUMO

BACKGROUND: Treatment of open angle glaucoma (OAG) and/or ocular hypertension (OHT) focuses on achievement of target intraocular pressure (IOP), with the objective of slowing disease progression. However, ocular surface health is an important consideration in the optimization of treatment. We report 6 patient cases in which enhanced IOP control was achieved following appropriate management of ocular surface inflammation and a therapeutic switch to the preservative-free (PF) tafluprost (0.0015%)/timolol (0.5%) fixed-dose combination (FC). CASE PRESENTATION: Six patient cases, aged 48-74 years, presented with OAG or OHT. Each patient had signs and symptoms of ocular surface disease (OSD). Cases 1-3 were each receiving maximal medical therapy for OAG; regimens comprising prostaglandin analogue (PGA), ß-blocker, carbonic anhydrase inhibitor (CAI) and α-2 agonist agents (including treatments containing preservative agent). Cases 1 and 2 reported IOP values ≥23 mmHg in each eye, and wide IOP fluctuations were identified when reviewing patient data concerning case 3 (11-20 mmHg). Maximal therapy was ceased and PF tafluprost/timolol FC was initiated, after which the signs and symptoms of OSD were improved and IOP was reduced (≤18 mmHg for cases 1-3) and stabilized. Cases 4 and 5 were diagnosed with OAG and case 6 had OHT. Each had symptoms and signs of OSD and were treated with a preserved PGA monotherapy (latanoprost 0.005% or bimatoprost 0.03%). At presentation, IOP was 24 mmHg in both eyes (case 4), ≥18 mmHg (case 5) and ≥ 22 mmHg (case 6). Following a switch to the PF tafluprost/timolol FC, OSD symptoms were improved and IOP was 14 mmHg (both eyes; case 4), ≤14 mmHg (case 5) and 16 mmHg (both eyes; case 6). CONCLUSIONS: In addition to IOP-lowering efficacy, approaches to the management of OAG and OHT should consider the impact of treatment tolerability and the susceptibility of these patients to OSD. The presence of ocular surface inflammation appears to be detrimental to adherence and therefore to the effectiveness of topical medications. Addressing OSD through the use of PF FC formations, such as the PF tafluprost/timolol FC, reduces exposure to potentially toxic agents and facilitates improvements in IOP control.


Assuntos
Glaucoma de Ângulo Aberto , Hipertensão Ocular , Idoso , Anti-Hipertensivos , Glaucoma de Ângulo Aberto/tratamento farmacológico , Humanos , Pessoa de Meia-Idade , Prostaglandinas F , Timolol/uso terapêutico
2.
Sci Rep ; 8(1): 5501, 2018 04 03.
Artigo em Inglês | MEDLINE | ID: mdl-29615671

RESUMO

Climate change is causing warming, deoxygenation, and acidification of the global ocean. However, manifestation of climate change may vary at local scales due to oceanographic conditions. Variation in stressors, such as high temperature and low oxygen, at local scales may lead to variable biological responses and spatial refuges from climate impacts. We conducted outplant experiments at two locations separated by ~2.5 km and two sites at each location separated by ~200 m in the nearshore of Isla Natividad, Mexico to assess how local ocean conditions (warming and hypoxia) may affect juvenile abalone performance. Here, we show that abalone growth and mortality mapped to variability in stress exposure across sites and locations. These insights indicate that management decisions aimed at maintaining and recovering valuable marine species in the face of climate change need to be informed by local variability in environmental conditions.


Assuntos
Mudança Climática , Gastrópodes , Oceanografia , Animais , Gastrópodes/metabolismo , Gastrópodes/fisiologia , Oxigênio/metabolismo , Estações do Ano , Temperatura
3.
Arch Soc Esp Oftalmol ; 80(6): 353-8, 2005 Jun.
Artigo em Espanhol | MEDLINE | ID: mdl-15986276

RESUMO

OBJECTIVE: Lymphoid Hyperplasia (LH) is a benign proliferative lymphocyte-rich process. Histologically, LH may be similar to a lymphoma. Its incidence has decreased because of new sophisticated diagnostic procedures and a better knowledge of lymphomas. Most of the cases are seen in patients between forty and sixty years of age. As there was no consensus about the best treatment, determining this was the objective of our study. METHOD: We describe three patients with a lymphoproliferative process affecting the ocular anexae, in whom histologic, immuno-histochemical and molecular studies were performed. PCR analysis allowed a definitive diagnosis to be made. RESULTS: Histologically, all three cases were diagnosed as LH; immuno-histochemically, one was diagnosed as an idiopathic orbital inflammation, and the other two, as LH. After PCR analysis, one of these latter two cases was definitively diagnosed as B-cell Non-Hodgkin's lymphoma. CONCLUSIONS: Today's molecular techniques allow us to make a definite diagnosis of lymphoma, because sometimes histology and immuno-histochemistry alone can result in a wrong diagnosis being made. LH of the ocular adnexae may be the first stage of a much more serious disease, and a benign hyperplasia at this site must lead to suspicion of lymphoma, which can then be diagnosed or excluded by the improved diagnostic procedures. Therefore, when we make a diagnosis of LH it is necessary to complete a full evaluation and institute a defined follow-up of the patient's clinical condition.


Assuntos
Neoplasias Oculares/diagnóstico , Aparelho Lacrimal/patologia , Linfoma de Células B/diagnóstico , Doenças Orbitárias/diagnóstico , Pseudolinfoma/diagnóstico , Corticosteroides/uso terapêutico , Adulto , Idoso , Criança , Opacidade da Córnea/complicações , Opacidade da Córnea/congênito , DNA de Neoplasias/análise , Diagnóstico Diferencial , Neoplasias Oculares/química , Neoplasias Oculares/patologia , Neoplasias Oculares/cirurgia , Feminino , Humanos , Linfoma de Células B/química , Linfoma de Células B/patologia , Linfoma de Células B/cirurgia , Masculino , Proteínas de Neoplasias/genética , Doenças Orbitárias/patologia , Doenças Orbitárias/cirurgia , Reação em Cadeia da Polimerase , Pseudolinfoma/tratamento farmacológico , Pseudolinfoma/patologia , Pseudolinfoma/cirurgia , Estudos Retrospectivos
4.
Arch Soc Esp Oftalmol ; 79(5): 243-6, 2004 May.
Artigo em Espanhol | MEDLINE | ID: mdl-15173969

RESUMO

CASE REPORT: Patient who consults for a recidivant orbital mass. Preliminary clinical and image studies suggested an initial differential diagnosis between a lachrymal gland tumor or an orbital located pseudotumor. However, the clinical evolution of the case required a re-evaluation of the preliminary diagnosis. The clinical, histologic and serologic findings were key in the final diagnosis. DISCUSSION: Wegener's granulomatosis is a necrotizing vasculitis. Classically it affects the upper airways, lungs and kidneys. Between 30% and 70% of patients present ophthalmic symptoms during the course of the illness. Ophthalmic affectation prior to systemic manifestations is less frequent and could delay final diagnosis.


Assuntos
Granulomatose com Poliangiite/complicações , Doenças Orbitárias/etiologia , Feminino , Granulomatose com Poliangiite/diagnóstico , Humanos , Pessoa de Meia-Idade
5.
Arch Soc Esp Oftalmol ; 78(2): 115-8, 2003 Feb.
Artigo em Espanhol | MEDLINE | ID: mdl-12647254

RESUMO

PURPOSE/METHOD: We present the case of a 10-year-old patient who was admitted as an emergency to our hospital with right ocular infection due to pansinusitis. He presented fever and malaise. Clinical, ophthalmic and radiologic examination confirmed the existence of an orbital abscess. Due to the poor evolution, surgical treatment was needed. RESULTS/CONCLUSION: Orbital cellulitis and orbital abscess are two different types of orbital infections. Being able to differentiate between then is very important for selecting the appropriate medical and surgical therapy. Medical treatment is a good solution for infections without abscesses, but surgery is usually needed for infections with an abscess. Abscess formation sometimes require surgical drainage of the orbital abscess with associated treatment of paranasal sinus.


Assuntos
Abscesso/etiologia , Doenças Orbitárias/etiologia , Sinusite/complicações , Criança , Humanos , Masculino
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