Recycling waste thermoplastic for energy efficient construction materials: An experimental investigation.

A large stream of research has studied the performance of waste plastics impregnated concrete, reporting multiple benefits and advocating its use in construction works. But no study has reported the merits of bricks impregnated with waste plastics. The present paper reports the results of experiments done on bricks made up of varying percentages of waste thermoplastics (0 - 10% by weight) and sand (60 - 70% by weight), holding percentages of fly ash and ordinary Portland cement constant at 15% (by weight) each. Three types of waste thermoplastics were used, forming three separate batches of bricks. The plastics were polycarbonates, polystyrenes, and mixed plastics. The bricks were cured under water for 28 days. Some of the batches were baked at temperatures ranging from 90 °C to 110 °C for 2 hours in order to melt the plastics to form voids. The bricks made with the above-stated compositions were found to possess low thermal conductivity and adequately high compressive strength. The compressive strength of these bricks is observed to be more than 17 MPa, which lies within the upper half of the range of strengths specified for bricks in the IS 1077:1992 standard. The waste plastics impregnated bricks display high thermal resistance, a feature that can add economic value to the brick manufacturers, motivating them to establish the necessary logistics for collection and use of all types of waste thermoplastics. The paper also presents a regression model to predict the compressive strength of bricks at varying plastic contents. The study, thus, introduces a new strand of research on sustainable recycling of waste thermoplastics in the context of the circular economy.

Medical Images are Safe - an Enhanced Chaotic Scrambling Approach.

The patient data confidentiality is one of the vital security aspects in e-Health and m-Health services. In particular, providing confidentiality to the patient's medical image is essential and the protection approaches have to be explored in-depth due to the rapid progress in the technologies of teleradiology and PACS. In this study, the pseudo random number generators (PRNGs), namely, the linear congruential generator (LCG) and XOR shift generator (XSG) are improved and combined with improved logistic 2D coupled chaotic map to provide enhanced chaos based encryption. The proposed scheme encrypts the Digital Imaging and Communication in Medicine (DICOM) images to protect the patient confidentiality during the storage and transfer in radiological information system (RIS). The cipher image was measured with various security analyses and tested with different test suites to prove its randomness.

Secured Medical Images - a Chaotic Pixel Scrambling Approach.

In this paper, a cryptosystem is proposed to encrypt 16-bit monochrome DICOM image using enhanced chaotic economic map. A new enhanced chaotic economic map (ECEM) is designed from the chaotic economic map which has better bifurcation nature and positive Lyapunov exponent values. In order to improve the sternness of the encryption algorithm, the enhanced chaotic map is employed to generate the pixel permutation, masking, and swapping sequences. The substitution operation is introduced in-between the standard permutation and diffusion operations. The robustness of the proposed image encryption algorithm is measured by various analyses such as histogram, key sensitivity, key space, number of pixel change rate (NPCR), unified average change intensity (UACI), information entropy and correlation coefficient. The results of the security analyses are compared with existing algorithms to validate that the proposed algorithm is better in terms of larger key space to resist brute force attacks and other common attacks on encryption.

Solid pseudopapillary tumour of pancreas.

Solid pseudopapillary tumour of pancreas (SPT) is an extremely rare pancreatic tumour, which has a low malignant potential and occurs mainly in young women. Pathologic and imaging findings include a well defined encapsulated pancreatic mass with cystic and solid components with evidence of haemorrhage. This is a case of a 16 years old girl who presented with upper abdominal pain of long duration and epigastric mass on palpation. Computed Tomography (CT) scan demonstrated a large well defined heterogenous attenuation mass of solid enhancing and cystic non enhancing areas, arising from the head of the pancreas. Radiologically it was diagnosed as a case of pancreatic neoplasm. Fine needle aspiration cytology (FNAC) and histopathology of the biopsy material diagnosed as solid pseudopapillary tumour of pancreas.

Benzoic acid, 4-hydroxy-, methyl ester from Smilax zeylanica Linn emerges as a potent inhibitor of CD27/CD70 signaling pathway.

Smilax zeylanica Linn is explored as a natural solution to inhibit the CD27/CD70 interaction crucial in T and B cell responses. This plant-based approach offers a cost-effective and promising drug candidate for overcoming challenges associated with anti-CD27 antibodies. The plants were macerated in an ethanol solution, and the cytotoxicity of crude extracts was determined using the MTT assay on Vero cell lines. Preliminary antiviral activity against the lentivirus plasmid was analyzed using plaque reduction assays for both ethanol and methanol fractions of the ethanol extract. Additionally, the methanol fraction underwent phytochemical analysis via GC-MS. Molecular docking with the CD27 receptor was carried out using Autodock Vina, followed by a 100 ns Molecular dynamics simulation with Gromacs. The expression of CD27 in MCF-7 was assessed by flow cytometry using the compound benzoic acid, 4-hydroxy-, methyl ester. On Vero cell lines, the ethanol extract was nontoxic. Furthermore, at 100 µg/ml, the ethanol extract and its methanol fraction showed percentage inhibitions of 64% and 66% in the plaque reduction assay. In addition, 22 chemicals were identified by GC-MS analysis of the ethanol extract's methanol fraction. Molecular Docking benzoic acid, 4-hydroxy-methyl ester of methanol fraction revealed the highest binding affinity with CD27. Molecular dynamics simulations of benzoic acid, 4-hydroxy-, methyl ester showed structure stability for a duration of 100 nanoseconds, Moreover, at a dosage of 50 µg/ml, benzoic acid, 4-hydroxy-, methyl ester was found to reduce CD27 expression in MCF-7 cells by 73.65% using flow cytometry.Communicated by Ramaswamy H. Sarma.

Postpartum atypical hemolytic uremic syndrome: Evaluating thrombotic microangiopathy in the pregnant woman.

Acute kidney injury in women during pregnancy and the puerperium is often ascribed to hypertensive complications of pregnancy, especially pre-eclampsia. However, rarer causes, including atypical hemolytic uremic syndrome (aHUS) can be triggered by pregnancy. We present a case of a woman with post-partum acute kidney injury due to aHUS, which was successfully treated with the C5a inhibitor eculizumab. We also present a summary of the evaluation and management of thrombotic microangiopathy in pregnancy.

Light induced toxicity of merocyanine 540-silica nanoparticle complex.

The electrostatic binding between the negatively charged lipophilic dye Merocyanine 540 and silica nanoparticles having 3-amino propyl groups at the surface has been characterized using absorption and fluorescence spectroscopy. The binding of the dye with the nanoparticle resulted in significant changes in its absorption spectra. Further the fluorescence intensity and lifetime gets enhanced by more than an order of magnitude. The results obtained suggest that this is due to the reduced photoisomerization rate of the dye bound to the nanoparticle. Consistent with the expectation that a reduction in the photoisomerization rate should enhance the singlet oxygen yield of the dye via intersystem crossing, the light induced toxicity of the dye-nanoparticle complex (tested with MCF cells) was observed to be higher compared to the free dye.

[Results of a cardiovascular disease prevention study among administrative employees of a large city]. / Ergebnisse einer Herz-Kreislauf-Präventionstudie bei Angestellten einer Grossstadtverwaltung.

In parallel with the demographic changes in an increasingly ageing German population, cardiovascular diseases (HKE) are becoming increasingly frequent and thus more and more important. The main aim of this work is to derive individual preventive measures on the basis of classic risk factors. This study was performed on 101 administrative employees of a large city (71 women and 30 men). The tests included a general investigation of medical status [current individual and family case history, body mass index (BMI)] as well as the determination of the following laboratory values: glucose, HDL and LDL cholesterol. In addition, the study was completed by a job analysis, including a survey of individual health behaviour. Referring to the PROCAM study, ten traditional risk factors for cardiovascular disease (arterial blood pressure >140/90 mmHg, BMI > or =25 kg/m (2), family disposition etc.) were probed. On the basis of these results individual risk profiles for each participant were rated. A vulnerable person received individually tailored prevention recommendations, which were adapted to the individual health behaviour of the subjects. Each of the 101 study participants received a personal results and prevention bulletin with individual test results and prevention suggestions. This high effort promises a better implementation as general advice for prevention in terms of classic risk factors.

SilkSatDb: a microsatellite database of the silkworm, Bombyx mori.

The SilkSatDb (silkmoth microsatellite database) (http://www.cdfd.org.in/silksatdb) is a relational database of microsatellites extracted from the available expressed sequence tags and whole genome shotgun sequences of the silkmoth, Bombyx mori. The database has been rendered with a simple and robust web-based search facility, developed using PHP. The SilkSatDb also stores information on primers developed and validated in the laboratory. Users can retrieve information on the microsatellite and the protocols used, along with informative figures and polymorphism status of those microsatellites. In addition, the interface is coupled with Autoprimer, a primer-designing program, using which users can design primers for the loci of interest.

Effect of UV-A on the linolenic acid micelles.

UV-A produced a dose-dependent linear increase of peroxidation in linolenic acid micelles as detected by the assay of (i) conjugated dienes, (ii) hydroperoxides, (iii) malondialdehyde (MDA), and (iv) the fluorescent adduct formed by the reaction of MDA with the amino acid, glycine. While sodium formate, dimethyl sulfoxide, superoxide dismutase, and ethylenediamine-tetraacetic acid produced no significant inhibition, some generally used singlet oxygen quenchers, beta-carotene, dimethylfuran, L-histidine, and sodium azide, caused significant inhibition of the UV-A-induced peroxidation of the linolenic acid micelles. alpha-Tocopherol and butylated hydroxytoluene produced more than 90% inhibition of the UV-A-induced peroxidation. ESR spectrometry revealed the formation of 2,2,6,6-tetramethylpiperidine oxide in the UV-A-irradiated aqueous solution of 2,2,6,6-tetramethylpiperidine. The involvement of singlet oxygen (1O2) in the UV-A-induced peroxidation of linolenic acid micelles is discussed.

N2 laser-induced oxidation of hemoproteins in red blood cell lysate.

Irradiation of red blood cell lysate with a N(2) laser (337 nm) was observed to induce oxidation of hemoproteins. This process showed a strong dependence on the concentration of red blood cell lysate and the dose of radiation. Studies of mechanisms and experiments with deoxygenated red blood cell lysate rule out involvement of any reactive oxygen species and suggest that the process is not a photodynamic reaction.

A reproducible experimental model of focal cerebral ischemia in the cat.

In the past experimental methods used for producing focal cerebral ischemia have had considerable difficulty with regard to reproducibility of the size of the infarcted region. In this study we have developed an experimental model which enables us to consistently produce focal regions of cerebral ischemia (resulting in infarction) which vary little in size in a number of animals. Thirty-seven cats (3-4 kg b. wt.) anesthetized with chloralose and urethane were used. Physiologic monitoring and adjustments maintained arterial blood values as follows: pCO2 27-35 Torr, pO2 100-150 Torr, pH +/- 7.4, glucose 200 mg%, hematocrit greater than 25. The left middle cerebral artery was exposed via a transorbital approach and occluded for 1-2 h with and without left and/or both carotid artery occlusion. Sixteen hours following the ischemic episode, the animals were sacrificed and sections of fresh brain tissue were processed for vital staining using 1% tetrazolium solution. With this method normal brain areas appear dark red, ischemic regions (without infarction) appear gray and irreversibly infarcted areas appear pinkish-white. The volumetric dimensions of the lesioned area were measured using a planimeter. The same tissue was also evaluated histologically by means of standard histopathologic techniques on paraffin-embedded material. Infarcted areas as delineated macroscopically by the tetrazolium correlated well with the light microscopic findings. Ten animals subjected to a 2-h occlusion of the left middle cerebral artery (LMCA) and both carotid arteries resulted in a reproducible infarct which was 3.2 +/- 0.7 ml in volume. This represents 13.3 +/- 2.9% of the total volume of both cerebral hemispheres (above the level of the inferior colliculus.(ABSTRACT TRUNCATED AT 250 WORDS)

Focal cerebral ischemia: reduction in size of infarcts by ventriculo-subarachnoid perfusion with fluorocarbon emulsion.

A new method for brain resuscitation following acute focal ischemic insult has been developed in this laboratory. The technique utilizes a surrogate route to supply cerebral metabolites and employs highly oxygenated fluorocarbons (OFNS), which are efficient gas transport and exchange agents, perfused through the ventriculo-subarachnoid spaces. We previously described a return of aerobic metabolism and EEG after severe global ischemia by oxygenated perfusions and now report treatment-induced reduction in the size of experienced cerebral infarction. Twenty-eight cats were anesthetized (choralose and urethane), tracheotomized and placed in a stereotactic frame. Physiologic adjustments assured arterial blood pCO2 28-35 Torr, pO2 100-150 Torr pH 7.4 and glucose less than 200 mg%. The left middle cerebral artery was exposed transorbitally and temporarily clipped along with both common carotids for 2 h. One hour later (3 h after ischemic onset) the treated group were perfused by the ventriculo-cisternal route either with OFNS [pO2 = 600 Torr; 3 ml/min 6 h, 2 ml/min 2 h, 1 ml/min 2 h, 0.5 ml/min 2 h at 10 mm Hg intracranial pressure (ICP)] or with the vehicle perfusate. Eighteen to twenty hours after the ischemic insult the animals were sacrificed. Sections of fresh brain of 0.5 mm thickness were incubated in 1% triphenyl tetrazolium chloride. The infarcted areas were confirmed with classic neuropathologic techniques. Areas of infarction (expressed in cm3 and as % of the brain) were measured using a planimeter. OFNS-treated brains contained 80% less infarcted tissue than the vehicle-perfused or untreated stroked animals. The infarcted areas were significantly treatment reduced (P less than 0.05 ANOVA and Bonferroni tests).(ABSTRACT TRUNCATED AT 250 WORDS)

Ganglioside-induced regeneration and reestablishment of axonal continuity in spinal cord-transected rats.

In this study we examined the effect of chronic GM-1 ganglioside treatment on the reestablishment of axonal continuity and functional recovery in spinal cord-transected rats. Previous studies have shown that chronic treatment with GM-1 ganglioside is effective in producing regeneration of lesioned mesostriatal dopaminergic neurons in the central nervous system [1, 2]. In addition, GM-1 ganglioside advances peripheral nerve regeneration following nerve crush injury [12]. Axonal continuity was determined by the ability of the spinal cord to transport horseradish peroxidase across the region of transection. Comparisons between ganglioside-treated and saline-treated controls showed that ganglioside treatment resulted in the reestablishment of axonal continuity between the spinal cord distal to the level of the transection and the brainstem. Saline-treated controls showed little evidence of axonal continuity between these two regions. Thus gangliosides induce reestablishment of axonal continuity and thereby could advance functional recovery in rats following spinal cord transection.

Giant basilar artery aneurysm presenting as a third ventricular tumor.

Giant aneurysm of the basilar artery presenting as a 3rd ventricular tumor is an unusual phenomenon. We are reporting a case in which a patient with a giant aneurysm of the basilar artery presented with symptoms of headaches and gait disturbance secondary to obstructive hydrocephalus. Although giant aneurysms presenting as mass lesions have been reported, the computed axial tomographic findings in our case were unique. Giant aneurysms of the basilar artery may be considered in the differential diagnosis of 3rd ventricular tumors.

Arachnoiditis presenting as a cervical cord neoplasm: two case reports.

Neurological evaluation supplemented by myelography has been highly successful in diagnosing spinal cord tumors. Our experience shows that a widening of the cord on myelography is not always diagnostic of spinal cord tumors. Two patients who presented clinically with evidence of spinal cord tumor and had a widening of the cord on myelography were found to have severe cervical arachnoiditis without any evidence of intrinsic cord abnormality. Hence, cervical arachnoiditis should be considered in the differential diagnosis of spinal cord tumor on myelography.

Intracerebral hematoma: spontaneous cure by drainage into the middle ear. A case report.

A case of a spontaneous cure of intracerebral hematoma by drainage into the middle ear is reported. A 38-year-old man was brought to the emergency room in a semicomatose state. He was found to have skull fractures and an intracerebral hematoma. His clinical condition improved, and a repeat computed tomographic scan showed disappearance of the hematoma and its replacement by air.

Management of lumbar translocation injuries: case reports.

Lumbar translocation (complete lumbar dislocation) injuries constitute a severe and highly unstable form of thoraco-lumbar spinal injury and are uncommon. Adequate management of such injuries includes removing the neural tissue compression and realigning and stabilizing the spine. Computerized axial tomographic scans of the spine are very dramatic in demonstrating encroachment on the spinal canal by bony fragments. We report two cases of lumbar translocation injuries with favorable outcomes. The patients were initially managed with halo-femoral traction, resulting in spinal reduction and eliminating the need for acute surgical intervention, and subsequently underwent posterior fusion for stability. Anterior decompression was done at a later date as computed tomography showed retropulsed intracanalicular bone fragments. The use of Harrington rod instrumentation and realignment of the spine did not free the canal of bony fragments and, hence, decompression was required.

Preservation of neuronal function during prolonged focal cerebral ischemia by ventriculocisternal perfusion with oxygenated fluorocarbon emulsion.

The left middle cerebral artery and both carotid arteries of 17 cats were occluded to evaluate the effects of oxygenated fluorocarbon emulsion on brain ischemia. Carotid and middle cerebral arteries were occluded concurrently for 2 hours, followed by occlusion of the middle cerebral artery only for another 24 hours. Six animals were treated with oxygenated fluorocarbon emulsion delivered by ventriculocisternal perfusion, 5 received ventriculocisternal perfusion with mock cerebrospinal fluid, and 6 were untreated. Perfusions were started 3 hours after the initial ischemic insult. Infarct size judged by tetrazolium staining and standard neuropathological stains was significantly smaller in the treated animals. The mechanism of protection is as yet unknown, but most likely reflects oxygen/nutrient diffusion into the ischemic middle cerebral artery zone from the ventricular fluorocarbon, or removal of harmful metabolites. The results imply that ventriculocisternal perfusion with fluorocarbon emulsion can preserve neuronal function during a major cerebral vessel occlusion. In the cat, therapy is effective if begun within 3 hours after ischemia starts.

Reanalysis of central cervical cord injury management.

Early investigators indicated that conservative management was superior to operative intervention in the treatment of central cord injuries. Their clinical data suggested that operative treatment, in fact, worsened the condition. Recent experience with this clinical entity, however, indicates that in selected patients operative intervention may be of value in improving the rate and degree of motor recovery. A retrospective study of all individuals admitted to our hospital (Delaware Valley Spinal Cord Injury Center) with central cervical spinal cord injury was done (28 patients). One-half had been treated with medical therapy alone (Group I); the others were treated both medically and surgically (Group II). Medical therapy consisted of intravenous mannitol, dexamethasone, and sodium bicarbonate given during the acute phase of the injury. Both groups were immobilized using either a halo or a Philadelphia collar. Criteria for entry into the surgical group were one or both of the following: (a) failure to improve progressively after an initial period of improvement, with persistent compression of neural tissue visualized on myelography and (b) unacceptable instability of the spinal bony elements. The patients were given neurological scores based on the motor power of the major muscle groups. The stability of the spine was scored using the Panjabi-White scale. The two groups were compared using Student's t-test and the two-factor analysis of variance. There was no significant difference in initial neurological scores between the groups. The surgical groups had a higher incidence of instability of the bony elements of the cervical spine, as judged by the Panjabi-White scale.(ABSTRACT TRUNCATED AT 250 WORDS)