Detalhe da pesquisa
1.
Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families.
J Pharmacol Exp Ther
; 343(3): 617-27, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22935731
2.
Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors.
Bioorg Med Chem Lett
; 22(14): 4528-31, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22727637
3.
Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases.
Bioorg Med Chem Lett
; 22(14): 4750-5, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22695126
4.
Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families.
Bioorg Med Chem Lett
; 22(9): 3208-12, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22465635
5.
Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer.
Bioorg Med Chem
; 20(15): 4635-45, 2012 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22766219
6.
Discovery of potent and selective thienopyrimidine inhibitors of Aurora kinases.
Bioorg Med Chem Lett
; 21(18): 5620-4, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21778056
7.
Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).
Bioorg Med Chem Lett
; 19(15): 4050-4, 2009 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19553114
8.
3-amino-benzo[d]isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases.
J Med Chem
; 51(5): 1231-41, 2008 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18260617
9.
Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors.
Bioorg Med Chem Lett
; 18(1): 386-90, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18023347
10.
The PARP inhibitor, ABT-888 potentiates temozolomide: correlation with drug levels and reduction in PARP activity in vivo.
Anticancer Res
; 28(5A): 2625-35, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-19035287
11.
Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer.
Bioorg Med Chem
; 16(14): 6965-75, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18541433
12.
ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models.
Clin Cancer Res
; 13(9): 2728-37, 2007 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17473206
13.
Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors.
J Med Chem
; 50(17): 4162-76, 2007 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-17658776
14.
Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor.
J Med Chem
; 50(7): 1584-97, 2007 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17343372
15.
1,4-Dihydroindeno[1,2-c]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel.
J Med Chem
; 50(9): 2011-29, 2007 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-17425296
16.
Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor.
Mol Cancer Ther
; 5(4): 995-1006, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16648571
17.
Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo.
Mol Cancer Ther
; 4(6): 977-86, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15956255
18.
Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors.
J Med Chem
; 48(19): 6066-83, 2005 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-16162008
19.
Phenoxyphenyl sulfone N-formylhydroxylamines (retrohydroxamates) as potent, selective, orally bioavailable matrix metalloproteinase inhibitors.
J Med Chem
; 45(1): 219-32, 2002 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-11754593
20.
Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor.
J Med Chem
; 53(8): 3142-53, 2010 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-20337371