1.
Bioorg Med Chem Lett
; 21(19): 5870-5, 2011 Oct 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21855335
RESUMO
A series of substituted imidazo[1,2-a]pyrazin-8-amines were discovered as novel breast tumor kinase (Brk)/protein tyrosine kinase 6 (PTK6) inhibitors. Tool compounds with low-nanomolar Brk inhibition activity, high selectivity towards other kinases and desirable DMPK properties were achieved to enable the exploration of Brk as an oncology target.