Detalhe da pesquisa
1.
Preclinical Efficacy and Anti-Inflammatory Mechanisms of Action of the Bruton Tyrosine Kinase Inhibitor Rilzabrutinib for Immune-Mediated Disease.
J Immunol
; 206(7): 1454-1468, 2021 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33674445
2.
The Proteome-Wide Potential for Reversible Covalency at Cysteine.
Angew Chem Int Ed Engl
; 58(33): 11385-11389, 2019 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31222866
3.
Prolonged and tunable residence time using reversible covalent kinase inhibitors.
Nat Chem Biol
; 11(7): 525-31, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-26006010
4.
Targeting interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) using a novel covalent inhibitor PRN694.
J Biol Chem
; 290(10): 5960-78, 2015 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25593320
5.
3-heterocyclyl quinolone inhibitors of the HCV NS5B polymerase.
Bioorg Med Chem Lett
; 22(1): 300-4, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22119470
6.
Discovery of Reversible Covalent Bruton's Tyrosine Kinase Inhibitors PRN473 and PRN1008 (Rilzabrutinib).
J Med Chem
; 65(7): 5300-5316, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35302767
7.
Quinolones as HCV NS5B polymerase inhibitors.
Bioorg Med Chem Lett
; 21(1): 82-7, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21145235
8.
The Irreversible Covalent Fibroblast Growth Factor Receptor Inhibitor PRN1371 Exhibits Sustained Inhibition of FGFR after Drug Clearance.
Mol Cancer Ther
; 16(12): 2668-2676, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28978721
9.
Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors.
J Med Chem
; 60(15): 6516-6527, 2017 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28665128
10.
Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase.
J Med Chem
; 57(5): 1914-31, 2014 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24195700
11.
De novo fragment design: a medicinal chemistry approach to fragment-based lead generation.
J Med Chem
; 56(7): 3115-9, 2013 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23509929
12.
Discovery of a novel series of potent non-nucleoside inhibitors of hepatitis C virus NS5B.
J Med Chem
; 56(20): 8163-82, 2013 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24069953
13.
Small molecule conformational preferences derived from crystal structure data. A medicinal chemistry focused analysis.
J Chem Inf Model
; 48(1): 1-24, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18183967
14.
The pK(BHX) database: toward a better understanding of hydrogen-bond basicity for medicinal chemists.
J Med Chem
; 52(14): 4073-86, 2009 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19537797