Detalhe da pesquisa
1.
A potential role for human UDP-glucuronosyltransferase 1A4 promoter single nucleotide polymorphisms in the pharmacogenomics of tamoxifen and its derivatives.
Drug Metab Dispos
; 42(9): 1392-400, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24917585
2.
Novel resveratrol-based substrates for human hepatic, renal, and intestinal UDP-glucuronosyltransferases.
Chem Res Toxicol
; 27(4): 536-45, 2014 Apr 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-24571610
3.
Single-walled carbon nanotube and graphene nanodelivery of gambogic acid increases its cytotoxicity in breast and pancreatic cancer cells.
J Appl Toxicol
; 34(11): 1188-99, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25220893
4.
CB1 and CB2 receptors are novel molecular targets for Tamoxifen and 4OH-Tamoxifen.
Biochem Biophys Res Commun
; 441(2): 339-43, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24148245
5.
Analysis of R- and S-hydroxywarfarin glucuronidation catalyzed by human liver microsomes and recombinant UDP-glucuronosyltransferases.
J Pharmacol Exp Ther
; 340(1): 46-55, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21972237
6.
Role of human UDP-glucuronosyltransferases in the biotransformation of the triazoloacridinone and imidazoacridinone antitumor agents C-1305 and C-1311: highly selective substrates for UGT1A10.
Drug Metab Dispos
; 40(9): 1736-43, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22659092
7.
Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.
Drug Metab Dispos
; 40(11): 2174-84, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22904561
8.
Natural prenylated resveratrol analogs arachidin-1 and -3 demonstrate improved glucuronidation profiles and have affinity for cannabinoid receptors.
Xenobiotica
; 42(2): 139-56, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21970716
9.
Conjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDP-glucuronosyltransferases.
Drug Metab Dispos
; 39(10): 1967-76, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21746969
10.
The crystal structure of human UDP-glucuronosyltransferase 2B7 C-terminal end is the first mammalian UGT target to be revealed: the significance for human UGTs from both the 1A and 2B families.
Drug Metab Rev
; 42(1): 133-44, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19821783
11.
Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids.
Drug Metab Dispos
; 37(7): 1496-504, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19339377
12.
Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7.
J Mol Biol
; 369(2): 498-511, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17442341
13.
Identification of hydroxywarfarin binding site in human UDP glucuronosyltransferase 1a10: phenylalanine90 is crucial for the glucuronidation of 6- and 7-hydroxywarfarin but not 8-hydroxywarfarin.
Drug Metab Dispos
; 36(11): 2211-8, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18725508
14.
The first aspartic acid of the DQxD motif for human UDP-glucuronosyltransferase 1A10 interacts with UDP-glucuronic acid during catalysis.
Drug Metab Dispos
; 36(3): 517-22, 2008 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18048489
15.
Human UDP-Glucuronosyltransferases: Effects of altered expression in breast and pancreatic cancer cell lines.
Cancer Biol Ther
; 16(5): 714-23, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25996841
16.
Ethylenediamine functionalized-single-walled nanotube (f-SWNT)-assisted in vitro delivery of the oncogene suppressor p53 gene to breast cancer MCF-7 cells.
Int J Nanomedicine
; 6: 1045-55, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21720516