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Org Lett
; 20(13): 3988-3991, 2018 07 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29906122
RESUMO
A new Passerini-type reaction in which hexafluoroisopropanol functions as the acid component is reported. The reaction tolerates a broad range of isocyanides and aldehydes, and the formed imidates can be reduced toward ß-amino alcohols under mild and metal-free conditions. In addition, the imidate products were shown to undergo an unprecedented retro-Passerini-type reaction under microwave conditions, providing valuable mechanistic information about the Passerini reaction and its variations.