RESUMO
The problem of memory enhancement is extremely important in intellectual activity areas and therapy of different types of dementia, including Alzheimer's disease (AD). The attempts to solve this problem have come from different research fields. In the first part of our review, we describe the results of targeting certain genes involved in memory-associated molecular pathways. The second part of the review is focused on the deep stimulation of brain structures that can slow down memory loss in AD. The third part describes the results of the use of non-invasive brain stimulation techniques for memory modulation, consolidation, and retrieval in healthy people and animal models. Integration of data from different research fields is essential for the development of efficient strategies for memory enhancement.
Assuntos
Doença de Alzheimer/patologia , Encéfalo/metabolismo , Memória , Doença de Alzheimer/metabolismo , Doença de Alzheimer/terapia , Animais , Proteína de Ligação a CREB/genética , Proteína de Ligação a CREB/metabolismo , Estimulação Encefálica Profunda , Regulação da Expressão Gênica , Humanos , Fator de Crescimento Insulin-Like II/genética , Fator de Crescimento Insulin-Like II/metabolismoRESUMO
In order to study spontaneous attentional lapses the experimental task was used that created a moderately high attentional load and involved response choice based on stimulus feature conjunction. The participant's average correct response rate was 85.1%; they made errors in 9.6% trials and response omissions in 5.4% trials. Peak N1 of the evoked potential was consistent across all behavioral outcomes, while peak P2 amplitude was significantly greater before errors and response omissions compared to correct responses. The analysis of polygraphic indexes (ECG, EMG, SGR) did not reveal any arousal level reduction before attentional lapses. The proposed interpretation of the results obtained is based on the assumption that attentional lapses are mediated by the suppression of external stimuli information processing caused by the state of mind-wandering.
Assuntos
Atenção/fisiologia , Potenciais Evocados Auditivos/fisiologia , Reconhecimento Fisiológico de Modelo/fisiologia , Adulto , Eletromiografia , Feminino , Lateralidade Funcional , Humanos , Masculino , Testes Psicológicos , Análise e Desempenho de TarefasRESUMO
The article analyzes consumer dispositions (preferences) in the Russian insurance market. Their influence on the digitalization of insurance activities has been revealed. The consumer preferences of policyholders and their impact on the digitalization of business processes have been studied. The actual results of a statistical study of the Internet sales channel of insurance services, as well as the results of a sociological study of consumer preferences of policyholders have been presented. The presence of consumer dispositions (preferences) in the insurance market that hinder the development of digitalization has been shown. Key trends in the digitalization of sales procedures and their settlement under insurance contracts have been identified. Recommendations have been formulated to take into account the peculiarities of consumer dispositions in the insurance market in the process of digitalization of insurance activities.