1.
Antimicrob Agents Chemother
; 68(4): e0154823, 2024 Apr 03.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38415988
RESUMO
The impact of penicillin-binding protein 3 (PBP3) modifications that may be identified in Escherichia coli was evaluated with respect to susceptibility to ß-lactam/ß-lactamase inhibitor combinations including ceftazidime-avibactam, imipenem-relebactam, meropenem-vaborbactam, aztreonam-avibactam, cefepime-taniborbactam, and to cefiderocol. A large series of E. coli recombinant strains producing broad-spectrum ß-lactamases was evaluated. While imipenem-relebactam showed a similar activity regardless of the PBP3 background, susceptibility to other molecules tested was affected at various levels. This was particularly the case for ceftazidime-avibactam, aztreonam-avibactam, and cefepime-taniborbactam.
Assuntos
Aztreonam , Ácidos Borínicos , Ácidos Borônicos , Ácidos Carboxílicos , Cefiderocol , Ceftazidima , Aztreonam/farmacologia , Meropeném/farmacologia , Cefepima/farmacologia , Proteínas de Ligação às Penicilinas , Escherichia coli , beta-Lactamases/metabolismo , Antibacterianos/farmacologia , Antibacterianos/uso terapêutico , Compostos Azabicíclicos/farmacologia , Compostos Azabicíclicos/química , Combinação de Medicamentos , Imipenem/farmacologia , Imipenem/química , Testes de Sensibilidade Microbiana
2.
J Antimicrob Chemother
; 78(9): 2382-2384, 2023 09 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37394537