Detalhe da pesquisa
1.
Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer.
Nature
; 578(7794): 306-310, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31969702
2.
Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors.
Bioorg Med Chem Lett
; 28(10): 1804-1810, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29678460
3.
Identification of novel resistance mechanisms to NAMPT inhibition via the de novo NAD+ biosynthesis pathway and NAMPT mutation.
Biochem Biophys Res Commun
; 491(3): 681-686, 2017 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28756225
4.
Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families.
J Pharmacol Exp Ther
; 343(3): 617-27, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22935731
5.
Selective Inhibition of the Second Bromodomain of BET Family Proteins Results in Robust Antitumor Activity in Preclinical Models of Acute Myeloid Leukemia.
Mol Cancer Ther
; 20(10): 1809-1819, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34253595
6.
Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies.
Cancer Res
; 77(11): 2976-2989, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28416490
7.
Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.
J Med Chem
; 60(20): 8369-8384, 2017 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28949521
8.
Antimicrobial susceptibility and molecular characterization of community-acquired methicillin-resistant Staphylococcus aureus.
Diagn Microbiol Infect Dis
; 43(3): 225-32, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12106956
9.
Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics.
Int J Cancer
; 119(12): 2784-94, 2006 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17019715
10.
Synthesis and antibacterial activity of 5-methoxy- and 5-hydroxy-6-fluoro-1,8-naphthyridone-3-carboxylic acid derivatives.
Bioorg Med Chem Lett
; 15(11): 2716-9, 2005 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-15911248
11.
Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides.
Bioorg Med Chem Lett
; 14(10): 2417-21, 2004 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-15109624
12.
Synthesis and SAR evaluation of oxadiazolopyrazines as selective Haemophilus influenzae antibacterial agents.
Bioorg Med Chem Lett
; 13(19): 3133-6, 2003 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-12951079