1.
ChemMedChem
; 13(8): 795-802, 2018 04 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29451954
RESUMO
Selective leads: In this study, we generated a new series of serotonin 5-HT7 receptor antagonists. Their synthesis, structure-activity relationships, and selectivity profiles are reported. This series includes 5-HT7 antagonists with unprecedented high selectivity for the 5-HT7 receptor, setting the stage for lead optimization of drugs acting on a range of neurological targets.