Detalhe da pesquisa
1.
Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity.
Mol Pharmacol
; 88(6): 1011-23, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26438213
2.
DLK1-DIO3 genomic imprinted microRNA cluster at 14q32.2 defines a stemlike subtype of hepatocellular carcinoma associated with poor survival.
J Biol Chem
; 286(35): 30706-30713, 2011 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21737452
3.
Pyridyl aminothiazoles as potent Chk1 inhibitors: optimization of cellular activity.
Bioorg Med Chem Lett
; 22(7): 2613-9, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22365762
4.
Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates.
Bioorg Med Chem Lett
; 22(7): 2609-12, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22374217
5.
In vitro anti-myeloma activity of the Aurora kinase inhibitor VE-465.
Br J Haematol
; 147(5): 672-6, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19751238
6.
Characterization of inhibitor binding to human kinesin spindle protein by site-directed mutagenesis.
Arch Biochem Biophys
; 484(1): 1-7, 2009 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19467625
7.
Development of thioquinazolinones, allosteric Chk1 kinase inhibitors.
Bioorg Med Chem Lett
; 19(4): 1240-4, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19155174
8.
Cotreatment with vorinostat enhances activity of MK-0457 (VX-680) against acute and chronic myelogenous leukemia cells.
Clin Cancer Res
; 14(19): 6106-15, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18829489
9.
Discovery and biochemical characterization of selective ATP competitive inhibitors of the human mitotic kinesin KSP.
Arch Biochem Biophys
; 469(2): 220-31, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17999913
10.
Inhibition of a mitotic motor protein: where, how, and conformational consequences.
J Mol Biol
; 335(2): 547-54, 2004 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-14672662
11.
Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I.
Mol Cancer Ther
; 1(9): 747-58, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12479371
12.
Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.
J Med Chem
; 46(14): 2973-84, 2003 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-12825937
13.
3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.
J Med Chem
; 45(12): 2388-409, 2002 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-12036349
14.
Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells.
Oncotarget
; 5(13): 5076-86, 2014 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24970803
15.
MK-1775, a novel Wee1 kinase inhibitor, radiosensitizes p53-defective human tumor cells.
Clin Cancer Res
; 17(17): 5638-48, 2011 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21799033
16.
Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer.
J Med Chem
; 51(14): 4239-52, 2008 Jul 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18578472
17.
Kinesin spindle protein (KSP) inhibitors. Part V: discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by beta-fluorination to overcome cellular efflux by P-glycoprotein.
Bioorg Med Chem Lett
; 17(10): 2697-702, 2007 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17395460
18.
Kinesin spindle protein (KSP) inhibitors. Part 6: Design and synthesis of 3,5-diaryl-4,5-dihydropyrazole amides as potent inhibitors of the mitotic kinesin KSP.
Bioorg Med Chem Lett
; 17(19): 5390-5, 2007 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17761419
19.
Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors.
Bioorg Med Chem Lett
; 17(21): 5989-94, 2007 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17804227
20.
Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.
Bioorg Med Chem Lett
; 17(20): 5677-82, 2007 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17766111