RESUMO
To determine the frequency of renal abnormalities occurring with Bancroftian filarial infections and to assess the effects of treatment on such abnormalities, we initiated a prospective, hospital-based study of 20 microfilaremic and five amicrofilaremic patients with Wuchereria bancrofti infections. Thorough clinical evaluations and detailed renal assessments were made prior to treatment and at multiple time points for 60 days following a standard twelve-day course of treatment with diethylcarbamazine (DEC). There were two important findings. First, even prior to DEC treatment, almost half of the microfilaremic patients had hematuria and/or proteinuria. Second, treatment with DEC induced these same abnormalities in almost all of the remaining microfilaremic patients. However, this DEC-induced hematuria and/or proteinuria was transient, and the long-term response to DEC in all of the microfilaremic patients was resolution of the abnormal renal findings during the two-month followup period. In the amicrofilaremic study patients, no hematuria or proteinuria was detected before, during, or after treatment with DEC.
Assuntos
Filariose Linfática/fisiopatologia , Hematúria/etiologia , Rim/fisiopatologia , Proteinúria/etiologia , Wuchereria bancrofti , Adolescente , Adulto , Animais , Nitrogênio da Ureia Sanguínea , Creatinina/sangue , Creatinina/urina , Dietilcarbamazina/uso terapêutico , Filariose Linfática/sangue , Filariose Linfática/tratamento farmacológico , Filariose Linfática/urina , Feminino , Seguimentos , Humanos , Masculino , Microfilárias , Pessoa de Meia-Idade , Militares , Estudos Prospectivos , Eosinofilia Pulmonar/sangue , Eosinofilia Pulmonar/tratamento farmacológico , Eosinofilia Pulmonar/fisiopatologia , Eosinofilia Pulmonar/urinaRESUMO
Lateral root development in Arabidopsis provides a model for the study of hormonal signals that regulate postembryonic organogenesis in higher plants. Lateral roots originate from pairs of pericycle cells, in several cell files positioned opposite the xylem pole, that initiate a series of asymmetric, transverse divisions. The auxin transport inhibitor N-1-naphthylphthalamic acid (NPA) arrests lateral root development by blocking the first transverse division(s). We investigated the basis of NPA action by using a cell-specific reporter to demonstrate that xylem pole pericycle cells retain their identity in the presence of the auxin transport inhibitor. However, NPA causes indoleacetic acid (IAA) to accumulate in the root apex while reducing levels in basal tissues critical for lateral root initiation. This pattern of IAA redistribution is consistent with NPA blocking basipetal IAA movement from the root tip. Characterization of lateral root development in the shoot meristemless1 mutant demonstrates that root basipetal and leaf acropetal auxin transport activities are required during the initiation and emergence phases, respectively, of lateral root development.