Detalhe da pesquisa
1.
Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates.
Nature
; 615(7953): 678-686, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36922586
2.
A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction.
Nature
; 598(7881): 504-509, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34616043
3.
Stimulation of the atypical chemokine receptor 3 (ACKR3) by a small-molecule agonist attenuates fibrosis in a preclinical liver but not lung injury model.
Cell Mol Life Sci
; 79(6): 293, 2022 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35562519
4.
Publisher Correction: A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction.
Nature
; 599(7883): E2, 2021 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-34671169
5.
Synthesis, Structure-Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication.
Molecules
; 27(3)2022 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35164317
6.
ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.
Biochem Biophys Res Commun
; 555: 134-139, 2021 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33813272
7.
Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping Machinery.
Antimicrob Agents Chemother
; 64(7)2020 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32340991
8.
An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein.
J Biol Chem
; 293(7): 2534-2545, 2018 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29237730
9.
Inhibitors of the integrase-transportin-SR2 interaction block HIV nuclear import.
Retrovirology
; 15(1): 5, 2018 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29329553
10.
Differential antiviral activities of respiratory syncytial virus (RSV) inhibitors in human airway epithelium.
J Antimicrob Chemother
; 73(7): 1823-1829, 2018 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29596680
11.
Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release.
Proc Natl Acad Sci U S A
; 112(11): E1363-72, 2015 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-25733887
12.
Identification of 1-((2,4-Dichlorophenethyl)Amino)-3-Phenoxypropan-2-ol, a Novel Antibacterial Compound Active against Persisters of Pseudomonas aeruginosa.
Antimicrob Agents Chemother
; 61(9)2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28630188
13.
Repurposing as a means to increase the activity of amphotericin B and caspofungin against Candida albicans biofilms.
J Antimicrob Chemother
; 69(4): 1035-44, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24284780
14.
Identification and characterization of an anti-pseudomonal dichlorocarbazol derivative displaying anti-biofilm activity.
Bioorg Med Chem Lett
; 24(23): 5404-8, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25453797
15.
Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor.
J Med Chem
; 67(5): 4063-4082, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38482827
16.
Mechanism of action of phthalazinone derivatives against rabies virus.
Antiviral Res
; 224: 105838, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38373533
17.
A Novel Irreversible TEAD Inhibitor, SWTX-143, Blocks Hippo Pathway Transcriptional Output and Causes Tumor Regression in Preclinical Mesothelioma Models.
Mol Cancer Ther
; 23(1): 3-13, 2024 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37748190
18.
Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells.
Bioorg Med Chem
; 21(22): 7107-17, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24095010
19.
A Robust Phenotypic High-Throughput Antiviral Assay for the Discovery of Rabies Virus Inhibitors.
Viruses
; 15(12)2023 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38140533
20.
A pan-serotype antiviral to prevent and treat dengue: A journey from discovery to clinical development driven by public-private partnerships.
Antiviral Res
; 210: 105495, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36567021